Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Yohei, Mukai"'
Autor:
Youya Nakazawa, Masayuki Miyano, Shuntaro Tsukamoto, Hiroyuki Kogai, Akihiko Yamamoto, Kentaro Iso, Satoshi Inoue, Yoshinobu Yamane, Yuki Yabe, Hirotatsu Umihara, Junichi Taguchi, Tsuyoshi Akagi, Atsumi Yamaguchi, Minaho Koga, Kohta Toshimitsu, Toshifumi Hirayama, Yohei Mukai, Akihito Machinaga
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all cancers. To improve PDAC therapy, we establish screening systems based on organoid and co-culture technologies and find a payload of antibody–drug conjugate (ADC), a br
Externí odkaz:
https://doaj.org/article/f57f6b1549874630a2370ee41f1543e6
Autor:
Taku Hatano, Renpei Sengoku, Hiroshi Nagayama, Naotake Yanagisawa, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Kenichi Kaida, Ryoko Ihara, Kazutomi Kanemaru, Osamu Kano
Publikováno v:
Neurology and Therapy, Vol 13, Iss 2, Pp 323-338 (2024)
Abstract Introduction A higher levodopa dose is a risk factor for motor complications in Parkinson’s disease (PD). Istradefylline (IST) is used as adjunctive treatment to levodopa in PD patients with off episodes, but its impact on levodopa dose ti
Externí odkaz:
https://doaj.org/article/297912391b29425383cd3fe2f9e7b7d9
Autor:
Yuta Suzuki, Takayuki Miyazaki, Hiroki Muto, Kenji Kubara, Yohei Mukai, Ryuji Watari, Shinya Sato, Keita Kondo, Shin-ichi Tsukumo, Koji Yasutomo, Masashi Ito, Kappei Tsukahara
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 226-240 (2022)
mRNA and lipid nanoparticles have emerged as powerful systems for the preparation of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. The emergence of novel variants or the necessity of cold chain logistics for
Externí odkaz:
https://doaj.org/article/4054f9f2cc084521a4b687b1b0017f6f
Autor:
Takehiro Tamura, Genichi Sugihara, Kyoji Okita, Yohei Mukai, Hiroshi Matsuda, Hiroki Shiwaku, Shunsuke Takagi, Hiromitsu Daisaki, Ukihide Tateishi, Hidehiko Takahashi
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract Dopamine dysfunction has been associated with depression. However, results of recent neuroimaging studies on dopamine transporter (DAT), which reflect the function of the dopaminergic system, are inconclusive. The aim of this study was to ap
Externí odkaz:
https://doaj.org/article/fe5c49ed62364e9aa783f9a39607672f
Autor:
Taku Hatano, Osamu Kano, Renpei Sengoku, Asako Yoritaka, Keisuke Suzuki, Noriko Nishikawa, Yohei Mukai, Kyoichi Nomura, Norihito Yoshida, Morinobu Seki, Miho Kawabe Matsukawa, Hiroo Terashi, Katsuo Kimura, Jun Tashiro, Shigeki Hirano, Hidetomo Murakami, Hideto Joki, Tsuyoshi Uchiyama, Hideki Shimura, Kotaro Ogaki, Jiro Fukae, Yoshio Tsuboi, Kazushi Takahashi, Toshimasa Yamamoto, Naotake Yanagisawa, Hiroshi Nagayama
Publikováno v:
BMC Neurology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Levodopa remains the most effective symptomatic treatment for Parkinson’s disease (PD) more than 50 years after its clinical introduction. However, the onset of motor complications can limit pharmacological intervention with lev
Externí odkaz:
https://doaj.org/article/05704b3d790741498c68e0d164b8370b
Autor:
Shunichi Shiozawa, Ken Tsumiyama, Yumi Miyazaki, Kenichi Uto, Keiichi Sakurai, Toshie Nakashima, Hiroko Matsuyama, Ai Doi, Miho Tarui, Manabu Izumikawa, Mai Kimura, Yuko Fujita, Chisako Satonaka, Takahiko Horiuchi, Tsukasa Matsubara, Motohiro Oribe, Takashi Yamane, Hidetoshi Kagawa, Quan-Zhen Li, Keiko Mizuno, Yohei Mukai, Kazuhiro Murakami, Takuji Enya, Shota Tsukimoto, Yoshiyuki Hakata, Masaaki Miyazawa, Kazuko Shiozawa
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103537- (2022)
Summary: Pathogens including autoantigens all failed to induce systemic lupus erythematosus (SLE). We, instead, studied the integrity of host's immune response that recognized pathogen. By stimulating TCR with an antigen repeatedly to levels that sur
Externí odkaz:
https://doaj.org/article/b767cf9d87924312bd8b11f3a665d055
Autor:
Yohei Mukai, Yoshihiko Furusawa, Yuko Morimoto, Yuka Hama, Tomoya Kawazoe, Yuji Saitoh, Takashi Sakamoto, Yuji Takahashi, Miho Murata
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 1, Iss , Pp 82-85 (2019)
Background: Patients with Parkinson's disease and related disorders (PDRD) may exhibit dropped head syndrome (DHS), which does not yet have an effective treatment. Objectives: To evaluate the effect of combining lidocaine injection into the bilateral
Externí odkaz:
https://doaj.org/article/e7ce61bcc2074ccc814a5ed7ffd3edda
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 3, Iss , Pp 100079- (2020)
Introduction: Tube-related adverse events (AEs) occur frequently in patients with Parkinson’s disease (PD) receiving levodopa-carbidopa intestinal gel therapy. Endoscopy has become evasive since the beginning of the coronavirus disease 2019 (COVID-
Externí odkaz:
https://doaj.org/article/4d3d5616933e4c2a8bea3e648dae7a3e
Autor:
Ayumi Tsuru, Kentaro Matsui, Ayano Kimura, Takuya Yoshiike, Rei Otsuki, Kentaro Nagao, Megumi Hazumi, Tomohiro Utsumi, Michio Fukumizu, Yohei Mukai, Yuji Takahashi, Takashi Sakamoto, Kenichi Kuriyama
Publikováno v:
Parkinsonism & Related Disorders. 98:86-91
Comorbid insomnia and poor sleep quality in Parkinson's disease (PD) are associated with a poor health-related quality of life (HRQoL). However, the relationship between HRQoL and sleep measures obtained using polysomnography (PSG) remains unclear. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2ac3765fe263bf10793dcaa255002c
https://doi.org/10.1016/j.parkreldis.2022.04.014
https://doi.org/10.1016/j.parkreldis.2022.04.014
Autor:
Shoko Ito, Keisuke Kuromiya, Miho Sekai, Hiroaki Sako, Kazuhito Sai, Riho Morikawa, Yohei Mukai, Yoko Ida, Moe Anzai, Susumu Ishikawa, Kei Kozawa, Takanobu Shirai, Nobuyuki Tanimura, Kenta Sugie, Junichi Ikenouchi, Motoyuki Ogawa, Isao Naguro, Hidenori Ichijo, Yasuyuki Fujita
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/24/2023, Vol. 120 Issue 43, p1-9, 45p