Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Yohannes Teffera"'
Publikováno v:
Innovative Issues and Approaches in Social Sciences, Vol 11, Iss 3 (2018)
Agricultural commodities play an important role in development. But traditional commodity trading, based on exporting produce in bulk at low prices, limits the profits margin from these products flows to producers in developing countries. Thus, the o
Externí odkaz:
https://doaj.org/article/7fa87f9e5fee4edca72cff602b4bcd61
Publikováno v:
Drug Metabolism Letters. 14:126-136
Introduction: A group of substituted benzothiazoles from a research project was found to have low microsomal clearance. However, these compounds had very high clearance in vivo. Methods: In the present study, the clearance mechanism of two of the str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1f3e38fe37e26b7dc9eea448cce050
https://doi.org/10.2174/1872312814666210405101419
https://doi.org/10.2174/1872312814666210405101419
Autor:
Shuyan Yi, Sonya G. Lehto, Stefan I. McDonough, Klaus Michelsen, Erin F. DiMauro, Hao Chen, Maosheng Zhang, Stephen Schneider, Shawn Ayube, Jason A. Luther, Matthew H. Plant, Xin Huang, David J. Matson, Jeffrey R. Simard, Howard Bregman, Jacinthe Gingras, Paul L. Shaffer, Yohannes Teffera
Publikováno v:
Nature Structural & Molecular Biology. 24:108-113
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective, central nervous system (CNS)-penetrant potentiators of glycine recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4d3f9eaf357c8330409b932db69a7e
https://doi.org/10.1038/nsmb.3329
https://doi.org/10.1038/nsmb.3329
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Publikováno v:
Innovative Issues and Approaches in Social Sciences, Vol 11, Iss 3 (2018)
Agricultural commodities play an important role in development. But traditional commodity trading, based on exporting produce in bulk at low prices, limits the profits margin from these products flows to producers in developing countries. Thus, the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca8de66e3763c5892d26047831d0477
http://www.iiass.com/pdf/IIASS-2018-no3-art4.pdf
http://www.iiass.com/pdf/IIASS-2018-no3-art4.pdf
Autor:
Shawn Ayube, Hao Chen, Yohannes Teffera, Jacinthe Gingras, Paul L. Shaffer, Paul Krolikowski, Angel Guzman-Perez, Kristin L. Andrews, Hakan Gunaydin, Richard Thomas Lewis, Klaus Michelsen, Jiali Hu, Liyue Huang, Sonya G. Lehto, Pamela Pegman, Erin F. DiMauro, Howard Bregman, Shuyan Yi, Xin Huang, Maosheng Zhang, Matthew H. Plant, Jeffrey R. Simard
Publikováno v:
Journal of medicinal chemistry. 60(3)
Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0578c8ef3924f9ebf3c9f90bbe82708
https://pubmed.ncbi.nlm.nih.gov/28001399
https://pubmed.ncbi.nlm.nih.gov/28001399
Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
Autor:
Zihao Hua, Bryan Egge, Erin L. Mullady, Hakan Gunaydin, John L. Buchanan, Steve Schneider, Xin Huang, Yohannes Teffera, Renee Emkey, Howard Bregman, Randy Serafino, Mary K. Stanton, Erin F. DiMauro, Jingzhou Liu, Virginia Berry, Douglas Saffran, Angel Guzman-Perez, Jennifer Dovey, Liyue Huang, Craig A. Strathdee, Susan M. Turci, Yan Gu, Paul S. Andrews, John Newcomb, Cindy Wilson, Ankita Mishra, Lisa Acquaviva, Nagasree Chakka
Publikováno v:
Journal of Medicinal Chemistry. 56:10003-10015
Tankyrases (TNKS1 and TNKS2) are proteins in the poly ADP-ribose polymerase (PARP) family. They have been shown to directly bind to axin proteins, which negatively regulate the Wnt pathway by promoting β-catenin degradation. Inhibition of tankyrases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba595497eee0272affa9da310eb1804
https://doi.org/10.1021/jm401317z
https://doi.org/10.1021/jm401317z
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:185-190
RATIONALE Although Desorption Electrospray Ionization (DESI) Mass Spectrometry Imaging (MSI) is uniquely suited for whole-body (WB) tissue distribution study of drugs, success in this area has been difficult. Here, we present WB tissue distribution s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f84619489dfc02d93669e0619c40f330
https://doi.org/10.1002/rcm.6775
https://doi.org/10.1002/rcm.6775
Autor:
Angel Guzman-Perez, Erin L. Mullady, Randy Serafino, Erin F. DiMauro, Hakan Gunaydin, Xin Huang, Liyue Huang, Jingzhou Liu, Virginia Berry, Bryan Egge, Nagasree Chakka, Cindy Wilson, Steve Schneider, John Newcomb, Yan Gu, Yohannes Teffera, Susan M. Turci, Ankita Mishra, Paul S. Andrews, Howard Bregman, Craig A. Strathdee
Publikováno v:
Journal of Medicinal Chemistry. 56:4320-4342
Tankyrase (TNKS) is a poly-ADP-ribosylating protein (PARP) whose activity suppresses cellular axin protein levels and elevates β-catenin concentrations, resulting in increased oncogene expression. The inhibition of tankyrase (TNKS1 and 2) may reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21eb09a2b123ca06a4a37ee2b8c466a
https://doi.org/10.1021/jm4000038
https://doi.org/10.1021/jm4000038