Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Yohannes G Asfaw"'
Autor:
Julia R. Palmucci, Blake E. Sells, Charles D. Giamberardino, Dena L. Toffaletti, Baodi Dai, Yohannes G. Asfaw, Laura G. Dubois, Zhong Li, Barbara Theriot, Wiley A. Schell, William Hope, Jennifer L. Tenor, John R. Perfect
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTInvasive fungal infections are a significant public health concern, with mortality rates ranging from 20% to 85% despite current treatments. Therefore, we examined whether a ketogenic diet could serve as a successful treatment intervention in
Externí odkaz:
https://doaj.org/article/1c4d26c9463d44078161728fc5c59925
Autor:
Praveen R Juvvadi, Christopher Gehrke, Jarrod R Fortwendel, Frédéric Lamoth, Erik J Soderblom, Erik C Cook, Michael A Hast, Yohannes G Asfaw, M Arthur Moseley, Trevor P Creamer, William J Steinbach
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003564 (2013)
The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase comprised of calcineurin A (CnaA) and calcineurin B (CnaB) subunits, localizes at the hyphal
Externí odkaz:
https://doaj.org/article/847cf8464757453d8a5060dcb40287de
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Shareef K. Shaheen, John Allen, Greg Waitt, Erik J. Soderblom, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 354 (2022)
Cellular recycling via autophagy-associated proteins is a key catabolic pathway critical to invasive fungal pathogen growth and virulence in the nutrient-limited host environment. Protein kinase A (PKA) is vital for the growth and virulence of numero
Externí odkaz:
https://doaj.org/article/5d1e3deab50c4838b224a9b4d520e93f
Autor:
Yohannes G. Asfaw, Robert M. Cabrera, John Bayliss, Bogdan J. Wlodarczyk, Thomas J. Cummings, Ying Linda Lin, Timothy M. George, John W. Steele, Richard H. Finnell, Sharon Bayliss
Publikováno v:
J Pediatr Surg
Background/Purpose In 2004, a heritable occurrence of spina bifida was reported in sheep on a farm in the United States. We maintained and characterized the spina bifida phenotype in this flock to assess its potential as an alternative surgical model
Autor:
John A. Allen, E. Keats Shwab, Yohannes G. Asfaw, Praveen R. Juvvadi, William J. Steinbach, Shareef Shaheen, D. Christopher Cole, Karen Joy Shaw, Mili Kapoor
Publikováno v:
Antimicrob Agents Chemother
Invasive aspergillosis (IA) due to Aspergillus fumigatus is a deadly infection for which new antifungal therapies are needed. Here, we demonstrate the efficacy of a Gwt1 inhibitor, APX2041, and its prodrug, APX2104, against A. fumigatus. The wild-typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1fcacc08beecd790d7a10ee300b2a8b
https://europepmc.org/articles/PMC8448089/
https://europepmc.org/articles/PMC8448089/
Autor:
Yohannes G. Asfaw, William J. Steinbach, Benjamin G. Bobay, Greg Waitt, John A. Allen, Praveen R. Juvvadi, Shareef Shaheen, E. Keats Shwab, Erik J. Soderblom, M. Arthur Moseley
Publikováno v:
mBio
mBio, Vol 11, Iss 6 (2020)
mBio, Vol 11, Iss 6 (2020)
PKA is essential for the virulence of eukaryotic human pathogens. Understanding PKA signaling mechanisms is therefore fundamental to deciphering pathogenesis and developing novel therapies.
Protein kinase A (PKA) signaling plays a critical role
Protein kinase A (PKA) signaling plays a critical role
Autor:
Shwab, Elliot, Juvvadi, Praveen R., Waitt, Greg, Shareef Shaheen, Allen, John, Soderblom, Erik J., Bobay, Benjamin G., Yohannes G. Asfaw, M. Arthur Moseley, Steinbach, William J.
Appendices for publication:Shwab EK, Juvvadi PR, Waitt G, Shaheen S, Allen J, IV, Soderblom EJ, Bobay BG, Asfaw YG, Moseley MA, Steinbach WJ. 2020. The protein kinase A-dependent phosphoproteome of the human pathogen Aspergillus fumigatus reveals div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4229245bac15b874b3e2061af38b7fd6
Publikováno v:
ILAR Journal. 59:144-149
The procedures necessary to perform testing in a veterinary diagnostic laboratory have inherent associated risks to personnel in regard to exposure to infectious agents. In research institutions animals can be experimentally infected, acquire natural
Autor:
Mili Kapoor, E. Keats Shwab, Praveen R. Juvvadi, Shareef Shaheen, John A. Allen, D Chris Cole, Karen Shaw, Yohannes G. Asfaw, William J. Steinbach
Publikováno v:
Open Forum Infectious Diseases
Background Aspergillus fumigatus is the leading cause of invasive aspergillosis (IA), a lethal infection among immunocompromised patients. Guideline-recommended antifungal therapy against IA is a triazole antifungal, with other secondary options incl
Autor:
Mary H. Foster, Robert M. Tighe, Yohannes G. Asfaw, Amy G. Clark, Francesca M. Korte, Anastasiya Birukova, Andrew J. Ghio, Lanette Fee, Victor L. Roggli, Emma J. Zhao, Jeffrey R. Ord
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Inhalational exposure to crystalline silica is linked to several debilitating systemic autoimmune diseases characterized by a prominent humoral immune component, but the mechanisms by which silica induces autoantibodies is poorly understood. To bette