Oxidative stress antagonizes fluoroquinolone drug sensitivity via the SoxR-SUF Fe-S cluster homeostatic axis.

Autor: Audrey Gerstel, Jordi Zamarreño Beas, Yohann Duverger, Emmanuelle Bouveret, Frédéric Barras, Béatrice Py

Publikováno v: PLoS Genetics, Vol 16, Iss 11, p e1009198 (2020)

The level of antibiotic resistance exhibited by bacteria can vary as a function of environmental conditions. Here, we report that phenazine-methosulfate (PMS), a redox-cycling compound (RCC) enhances resistance to fluoroquinolone (FQ) norfloxacin. Ge

Externí odkaz: https://doaj.org/article/c810cf3b3f1d403aac178eee995ace44

Molecular Biology and Genetic Tools to Investigate Functional Redundancy Among Fe-S Cluster Carriers in E. coli

Autor: Yohann Duverger, Béatrice Py

Publikováno v: Fe-S Proteins
Fe-S Proteins, 2353, Springer US, pp.3-36, 2021, Methods in Molecular Biology, ⟨10.1007/978-1-0716-1605-5_1⟩
Methods in Molecular Biology ISBN: 9781071616048

Iron-sulfur (Fe-S) clusters are among the oldest protein cofactors, and Fe-S cluster-based chemistry has shaped the cellular metabolism of all living organisms. Over the last 30 years, thanks to molecular biology and genetic approaches, numerous acto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91ea445450e20245c9b5f8af7198ffa
https://hal-amu.archives-ouvertes.fr/hal-03377116

The sRNA RyhB regulates the synthesis of the Escherichia coli methionine sulfoxide reductase MsrB but not MsrA.

Autor: Julia Bos, Yohann Duverger, Benoît Thouvenot, Claude Chiaruttini, Christiane Branlant, Mathias Springer, Bruno Charpentier, Frédéric Barras

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63647 (2013)

Controlling iron homeostasis is crucial for all aerobically grown living cells that are exposed to oxidative damage by reactive oxygen species (ROS), as free iron increases the production of ROS. Methionine sulfoxide reductases (Msr) are key enzymes

Externí odkaz: https://doaj.org/article/7395c39c28b94ed0858e6bbb5e74c31e

Tight regulation of the intS gene of the KplE1 prophage: a new paradigm for integrase gene regulation.

Autor: Gaël Panis, Yohann Duverger, Elise Courvoisier-Dezord, Stéphanie Champ, Emmanuel Talla, Mireille Ansaldi

Publikováno v: PLoS Genetics, Vol 6, Iss 10 (2010)

Temperate phages have the ability to maintain their genome in their host, a process called lysogeny. For most, passive replication of the phage genome relies on integration into the host's chromosome and becoming a prophage. Prophages remain silent i

Externí odkaz: https://doaj.org/article/fe6e1dd67c094ed1bdae308b2e950abf

Silver potentiates aminoglycoside toxicity by enhancing their uptake

Autor: Benjamin Ezraty, Frédéric Barras, Isabelle Martin-Verstraete, Marion Herisse, Yohann Duverger

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2017, 105 (1), pp.115--126. ⟨10.1111/mmi.13687⟩
Molecular Microbiology, 2017, 105 (1), pp.115--126. ⟨10.1111/mmi.13687⟩

International audience; The predicted shortage in new antibiotics has prompted research for chemicals that could act as adjuvant and enhance efficacy of available antibiotics. In this study, we tested the effects of combining metals with aminoglycosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7633c016243f41abe0cf0fbc9125f788
https://hal.archives-ouvertes.fr/hal-01640020