Sequential one pot double C H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes

Autor: Yohann Berhault, Marie Jouanne, Ikram Slimani, Charline Kieffer, Anne Sophie Voisin-Chiret, Rémi Legay, Jana Sopkova-de Oliveira Santos, Sylvain Rault, Victor Babin

Publikováno v: Tetrahedron
Tetrahedron, Elsevier, 2017, 73 (37), pp.5509-5516. ⟨10.1016/j.tet.2017.07.049⟩

International audience; We present Csingle bondH heteroarylation reactions between thiophene and variously substituted bromopyridines. The objective was to synthesize unsymmetrical 2,5-bipyridylthiophenes. We studied the reaction conditions allowing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1182640ee526eae33da30b417b2319d0
https://hal.archives-ouvertes.fr/hal-02043719

Iodoindazoles with Selective Magnesiation at Position 3: A Route to Highly Functionalized Indazoles

Autor: Frédéric Fabis, Yohann Berhault, Thomas Cailly, Silvia Stiebing, Bao Vy Lam, Valérie Collot, Christine Fossey

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2016, 22 (13), pp.4440-4446. ⟨10.1002/chem.201504828⟩

International audience; A unique route to highly functionalized indazoles is described. A regioselective magnesiation at position 3 of 4-, 5-, 6- and 7-iodo-2-THP-indazoles (THP=tetrahydropyranyl) has been developed using TMPMgCl⋅LiCl (TMP=2,2,6,6-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d988b624d2b046d59b9557dd9ba6f8f6
https://hal.archives-ouvertes.fr/hal-02043771

Catalytic chemical amide synthesis at room temperature: one more step toward peptide synthesis

Autor: Yohann Berhault, Jacques Rouden, Tharwat Mohy El Dine, Jérôme Blanchet, William Erb

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2015, 80 (9), pp.4532-4544. ⟨10.1021/acs.joc.5b00378⟩

International audience; An efficient method has been developed for direct amide bond synthesis between carboxylic acids and amines via (2-(thiophen-2-ylmethyl)phenyl)boronic acid as a highly active bench-stable catalyst. This catalyst was found to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e174a4695b6665c3ef840b3ccf0eb0fc
https://pubmed.ncbi.nlm.nih.gov/25849872