Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yogesh B. Khandokar"'
Autor:
Sofiya Tsimbalyuk, Aleksander Shornikov, Parul Srivastava, Van Thi Bich Le, Imani Warren, Yogesh B. Khandokar, Misty L. Kuhn, Jade K. Forwood
Publikováno v:
Cells, Vol 12, Iss 14, p 1829 (2023)
Polyamines are simple yet critical molecules with diverse roles in numerous pathogenic and non-pathogenic organisms. Regulating polyamine concentrations affects the transcription and translation of genes and proteins important for cell growth, stress
Externí odkaz:
https://doaj.org/article/94572e486c244459aa8fd536b1bf03cc
Autor:
Emma J. Petrie, Ashish Sethi, Michael D. W. Griffin, Yee-Foong Mok, Christopher J Draper-Joyce, Ross A. D. Bathgate, Mohammad Akhter Hossain, Daniel Scott, Paul R. Gooley, Timothy M. Ryan, Riley D. Metcalfe, Shoni Bruell, Mohammad Hossein Tanipour, Fei Yan, Yogesh B. Khandokar
Publikováno v:
Journal of molecular biology. 433(21)
Our poor understanding of the mechanism by which the peptide-hormone H2 relaxin activates its G protein coupled receptor, RXFP1 and the related receptor RXFP2, has hindered progress in its therapeutic development. Both receptors possess large ectodom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b97257b6a2797d658800384f96b863
https://pubmed.ncbi.nlm.nih.gov/34454945
https://pubmed.ncbi.nlm.nih.gov/34454945
Autor:
Parul Srivastava, Yogesh B Khandokar, Crystall M D Swarbrick, Noelia Roman, Zainab Himiari, Subir Sarker, Shane R Raidal, Jade K Forwood
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e102348 (2014)
The Gcn5-related N-acetyltransferases (GNATs) are ubiquitously expressed in nature and perform a diverse range of cellular functions through the acetylation of small molecules and protein substrates. Using activated acetyl coenzyme A as a common acet
Externí odkaz:
https://doaj.org/article/89230eb841c74cfd951692340819ba54
Publikováno v:
Journal of Structural Biology. 210:107477
Acyl-coenzyme A thioesterases (ACTs) catalyse the hydrolysis of thioester bonds between fatty-acyl chains and coenzyme A (CoA), producing a free fatty-acyl chain and CoA. These enzymes are expressed ubiquitously across prokaryotes and eukaryotes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8fa24df7f5f6c4eb76183a39a6b8468
https://doi.org/10.1016/j.jsb.2020.107477
https://doi.org/10.1016/j.jsb.2020.107477
Autor:
Maria L. Sandoval-Romero, Michael N. T. Souter, Wael Awad, Nicholas A Gherardin, Shihan Li, Ligong Liu, Glen P. Westall, Rebecca Seneviratna, David P. Fairlie, Alexandra J. Corbett, Jarrod J. Sandow, Edward M. Giles, Daniel G. Pellicci, Adam P Uldrich, Anthony W. Purcell, Yogesh B. Khandokar, Sidonia B G Eckle, Sri H. Ramarathinam, Jacinta M. Wubben, Andrew I. Webb, Richard Berry, Michael T. Rice, Richard W. Tothill, Jamie Rossjohn, Martin S. Davey, Jérôme Le Nours, Florian Wiede, Samuel J. Redmond, James McCluskey, Hugh H. Reid, Benjamin S. Gully, Tony Tiganis, T. Praveena, Anouk von Borstel, Dale I. Godfrey
Publikováno v:
Trends in Biochemical Sciences
A different way for γδ T cells to bind The ligands bound by γδ T cell receptors (TCRs) are less well characterized than those of their αβ TCR cousins, which are antigens presented by major histocompatibility complex (MHC) and related proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde25b24363fdce4eb075372e05f6dc5
https://pubmed.ncbi.nlm.nih.gov/32299647
https://pubmed.ncbi.nlm.nih.gov/32299647
Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function
Autor:
Kathryn D. Tuttle, Natacha Veerapen, S. Harsha Krovi, Laurent Gapin, Jingjing Zhang, Romain Bedel, Jérôme Le Nours, Yogesh B. Khandokar, Srinivasan Sundararaj, Jamie Rossjohn, Jennifer L. Matsuda, T. Praveena, Gurdyal S. Besra
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(6)
MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324d7e05b50c0433ec273d4690dbb620
https://pubmed.ncbi.nlm.nih.gov/29351991
https://pubmed.ncbi.nlm.nih.gov/29351991
Autor:
Yogesh B. Khandokar, Seyed A. Ghorashi, Zainab Himiari, Crystall M.D. Swarbrick, Subir Sarker, Jade K. Forwood, Shane Raidal
Publikováno v:
Journal of Virological Methods. :1-8
Structural insights into the biology of viruses such as beak and feather disease virus (BFDV) which do not replicate in cell cultures are increasingly reliant on recombinant methods for protein production and purification. Development of efficient me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba3d3494f3ab9b677c2f89362aabc50
https://doi.org/10.1016/j.jviromet.2015.02.005
https://doi.org/10.1016/j.jviromet.2015.02.005
Autor:
Jade K. Forwood, Shane Raidal, Nathan Cowieson, Shubhagata Das, Yogesh B. Khandokar, Subir Sarker, Kate Smith, David Aragão, P. Srivastava
Publikováno v:
The Journal of biological chemistry. 292(50)
Thioesterases catalyze the cleavage of thioester bonds within many activated fatty acids and acyl-CoA substrates. They are expressed ubiquitously in both prokaryotes and eukaryotes and are subdivided into 25 thioesterase families according to their c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7be748aa216d61437bbc2c19e4658144
https://pubmed.ncbi.nlm.nih.gov/28972175
https://pubmed.ncbi.nlm.nih.gov/28972175
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 70:244-247
Staphylococcus aureus is the causative agent of many diseases, including meningitis, bacteraemia, pneumonia, food poisoning and toxic shock syndrome. Structural characterization of the PaaI-like thioesterase SAV0944 (SaPaaI) from S. aureus subsp. aur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed2cef6e14222f4e9857a9f2f9429e5
https://doi.org/10.1107/s2053230x14000338
https://doi.org/10.1107/s2053230x14000338
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 70:211-214
Staphylococcus aureus is a prevalent microorganism that is capable of causing a wide range of infections and diseases. Several strains of this bacterial species have developed antibiotic resistance to methicillin and vancomycin, and higher death rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e6f0e362f71c90ec7eb280c87483f1
https://doi.org/10.1107/s2053230x13034493
https://doi.org/10.1107/s2053230x13034493