Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yogendra S. Rajawat"'
Autor:
Meera A. Srikanthan, Olivier Humbert, Kevin G. Haworth, Christina Ironside, Yogendra S. Rajawat, Bruce R. Blazar, Rahul Palchaudhuri, Anthony E. Boitano, Michael P. Cooke, David T. Scadden, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 455-464 (2020)
Conditioning chemotherapy is used to deplete hematopoietic stem cells in the recipient’s marrow, facilitating donor cell engraftment. Although effective, a major issue with chemotherapy is the systemic genotoxicity that increases the risk for secon
Externí odkaz:
https://doaj.org/article/c5914d1b216b478194b953206195ad04
Autor:
Olivier Humbert, Frieda Chan, Yogendra S. Rajawat, Troy R. Torgerson, Christopher R. Burtner, Nicholas W. Hubbard, Daniel Humphrys, Zachary K. Norgaard, Patricia O'Donnell, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Peter J. Felsburg, David J. Rawlings, Hans-Peter Kiem
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 987-999 (2018)
Abstract: Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires recipient conditioning, extensive cell manipulation, and sophisticated facilities. With
Externí odkaz:
https://doaj.org/article/3e55cf5967d441c1ad4a379d1df78d1a
Autor:
Stefan Radtke, Yogendra S. Rajawat, Dnyanada Pande, Hans-Peter Kiem, Savannah Cook, Martin E. Wohlfahrt, Mark Enstrom, Olivier Humbert
Publikováno v:
Hum Gene Ther
Hematopoietic stem and progenitor cell (HSPC)-based ex vivo gene therapy has demonstrated clinical success for X-linked severe combined immunodeficiency (SCID-X1) patients who lack a suitable donor for HSPC transplantation. Nevertheless, this form of
Autor:
Anthony E. Boitano, Rahul Palchaudhuri, Hans-Peter Kiem, David T. Scadden, Meera A. Srikanthan, Christina Ironside, Olivier Humbert, Kevin G. Haworth, Bruce R. Blazar, Yogendra S. Rajawat, Michael P. Cooke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 455-464 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Conditioning chemotherapy is used to deplete hematopoietic stem cells in the recipient’s marrow, facilitating donor cell engraftment. Although effective, a major issue with chemotherapy is the systemic genotoxicity that increases the risk for secon
Publikováno v:
Viruses
Foamy viruses (FVs) are nonpathogenic retroviruses that infect various animals including bovines, felines, nonhuman primates (NHPs), and can be transmitted to humans through zoonotic infection. Due to their non-pathogenic nature, broad tissue tropism
Publikováno v:
Antioxidants & Redox Signaling. 14:2165-2177
Retinoic acids (RAs) have diverse biologic effects and regulate several cellular functions. Here, we investigated the role of RA on autophagy by studying its effects on autophagosome (AUT) maturation, as well as on upstream regulators of autophagosom
Publikováno v:
Ageing Research Reviews. 8:199-213
The lysosomal network is the major intracellular proteolytic system accounting for more than 98% of long-lived bulk protein degradation and recycling particularly in tissues such as liver and muscles. Lysosomes are the final destination of intracellu
Autor:
Uttara Chaturvedi, Barkha Ratta, Yogendra S. Rajawat, Ashok K. Tiwari, Anant Rai, S. K. Palia, P.V. Ravindra
Publikováno v:
Journal of Virological Methods. 149:260-263
The present study was aimed at developing the polymerase chain reaction (PCR) assay for detection of canine adenoviruses from faecal or urine samples. Urine or faecal samples were treated with chloroform or activated charcoal to eliminate the PCR inh
Autor:
Ioannis Bossis, Yogendra S. Rajawat
Publikováno v:
HORMONES. 7:46-61
Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins, macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis requires continuous removal of worn-out components and replacement with new
Publikováno v:
Autophagy. 6:1224-1226
Autophagy is an intracellular catabolic process that responds with great sensitivity to nutrient availability, implying that certain macro- or micro-nutrients are involved. We found that retinoic acid promotes autophagosome maturation through a pathw