Výsledky vyhledávání - "Yogan, Khatri"

Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases

Autor: Vikram V. Shende, Natalia R. Harris, Jacob N. Sanders, Sean A. Newmister, Yogan Khatri, Mohammad Movassaghi, Kendall N. Houk, David H. Sherman

Publikováno v: Angewandte Chemie (International ed. in English).

In the biosynthesis of the tryptophan-linked dimeric diketopiperazines (DKPs), cytochromes P450 selectively couple DKP monomers to generate a variety of intricate and isomeric frameworks. To determine the molecular basis for selectivity of these bioc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b0c070158731747ee63384f1cc8c4a
https://pubmed.ncbi.nlm.nih.gov/36610039

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Structure and Function of NzeB, a Versatile C–C and C–N Bond-Forming Diketopiperazine Dimerase

Autor: Justin Kim, Sean A. Newmister, Mohammad Movassaghi, Tyler J. Doyon, K. N. Houk, Vikram V. Shende, Petra Lindovska, Jacob N. Sanders, Yogan Khatri, Fengan Yu, David H. Sherman

Publikováno v: J Am Chem Soc

The dimeric diketopiperazine (DKPs) alkaloids are a diverse family of natural products (NPs) whose unique structural architectures and biological activities have inspired the development of new synthetic methodology to access these molecules. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717247ce2d2a8b67ec603f907d00923
https://doi.org/10.1021/jacs.0c06312

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Epoxidation and late-stage C-H functionalization by P450 TamI is mediated by variant heme-iron oxidizing species

Autor: Mark A. Maskeri, Aneta Turlik, David H. Sherman, John Montgomery, Yogan Khatri, Rosa V. Espinoza, K. N. Houk, Anjanay Nangia

P450-catalyzed hydroxylation reactions are well understood mechanistically including the identity of the active oxidizing species. However, the catalytically active heme-iron species in P450 iterative oxidation cascades that involve mechanistically d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a65835ce7da0d52cb764417b6f2eb6
https://doi.org/10.26434/chemrxiv-2021-9q343

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Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C–H Functionalization and Epoxidation of Tirandamycin Antibiotics

Autor: Sean A. Newmister, S. Wald Grossman, Rosa V. Espinoza, John Montgomery, Yogan Khatri, Caylie A. McGlade, David H. Sherman, Marc Garcia-Borràs, Kersti Caddell Haatveit, Jin Yi Tan, K. N. Houk, Jennifer J. Schmidt

Publikováno v: ACS Catal
ACS catalysis, vol 11, iss 13

Iterative P450 enzymes are powerful biocatalysts for selective late-stage C-H oxidation of complex natural product scaffolds. These enzymes represent new tools for selectivity and cascade reactions, facilitating direct access to core structure divers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a5b77bfadbdceadc34c4b2d4af0813
https://europepmc.org/articles/PMC8739753/

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Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973

Autor: David H. Sherman, Robert M. Hohlman, Himadri B. Pakrasi, Cory J. Knoot, Yogan Khatri

Publikováno v: ACS Synthetic Biology. 8:1941-1951

Cyanobacteria produce numerous valuable bioactive secondary metabolites (natural products) including alkaloids, isoprenoids, nonribosomal peptides, and polyketides. However, the genomic organization of the biosynthetic gene clusters, complex gene exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9aabcb59b6fefecff2087e21146c83e5
https://doi.org/10.1021/acssynbio.9b00229

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Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis

Autor: Sean A. Newmister, Yogan Khatri, Robert M. Hohlman, Kendall N. Houk, David H. Sherman, Andrew N. Lowell, Shasha Li, Nikki R. Keramati, Jacob N. Sanders

Publikováno v: ACS catalysis, vol 11, iss 8
ACS Catal

Hapalindoles and related compounds (ambiguines, fischerindoles, welwitindolinones) are a diverse class of indole alkaloid natural products. They are typically isolated from the Stigonemataceae order of cyanobacteria and possess a broad scope of biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a746262a84047f4382b698f0a0cb5aed
https://escholarship.org/uc/item/1q46f7xd

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Molecular Basis of Iterative C–H Oxidation by TamI, a Multifunctional P450 Monooxygenase from the Tirandamycin Biosynthetic Pathway

Autor: Marc Garcia-Borràs, Larissa M. Podust, Kinshuk Raj Srivastava, Yogan Khatri, Rachel M. Martini, Kersti Caddell Haatveit, David H. Sherman, Rosa V. Espinoza, Kendall N. Houk, Sean A. Newmister

Publikováno v: ACS Catal
ACS catalysis, vol 10, iss 22

Biocatalysis offers an expanding and powerful strategy to construct and diversify complex molecules by C-H bond functionalization. Due to their high selectivity, enzymes have become an essential tool for C-H bond functionalization and offer complemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a3a7cdf139fe3c7f77dce95f5d2919
https://doi.org/10.26434/chemrxiv.12710159

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Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids

Autor: Haruichi Asahara, Shasha Li, Johnny Mendoza, David H. Sherman, Yogan Khatri, Robert M. Hohlman, Andrew N. Lowell

Publikováno v: ACS Synth Biol

Genome sequencing and bioinformatics tools have facilitated the identification and expression of an increasing number of cryptic biosynthetic gene clusters (BGCs). However, functional analysis of all components of a metabolic pathway to precisely det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55692c7ebbb8e821d8cc38681e655863
https://pubmed.ncbi.nlm.nih.gov/32302487

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A Versatile Chemoenzymatic Synthesis for the Discovery of Potent Cryptophycin Analogs

Autor: Frederick A. Valeriote, Yogan Khatri, Halina Pietraszkiewicz, David H. Sherman, Scott I Brody, Jennifer J. Schmidt, Catherine Zhu

Publikováno v: ACS Chem Biol

The cryptophycins are a family of macrocyclic depsipeptide natural products that display exceptionally potent anti-proliferative activity against drug-resistant cancers. Unique challenges facing the synthesis and derivatization of this complex group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863135cc7bacf299bffe1be0fbafef35
https://europepmc.org/articles/PMC7094870/

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