Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Yoffi Segall"'
Autor:
Yoffi Segall
Publikováno v:
Journal of Agricultural and Food Chemistry. 59:2845-2856
Most organophosphate (OP) pesticides require metabolic activation before attacking the target site, as opposed to chemical nerve agents, such as VX and sarin, which inhibit the enzyme directly. The majority of OP pesticides exhibit weak anticholinest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a76661a589677fe6f6a8904b2aa5e30
https://doi.org/10.1021/jf102262p
https://doi.org/10.1021/jf102262p
Publikováno v:
Synthetic Communications. 38:848-857
Two methods for the synthesis of unsubstituted diethyl cyclopropylphosphonate are described. One method is a reaction between cyclopropylmagnesium bromide and diethyl chlorophosphite to give diethyl cyclopropylphosphonite, followed by oxidation with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7709fdca92de39bc13bf6f9b884c9c62
https://doi.org/10.1080/00397910701845332
https://doi.org/10.1080/00397910701845332
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 183:420-424
The reactions of 2-alkoxy-1,3,2-dioxaphospholane 2-oxide with various nucleophiles were studied both experimentally and theoretically. These studies show that 5-membered ring phosphate triesters act as ambident electrophiles: hard and bulky nucleophi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f47626db8af305526a3bbc0496a930
https://doi.org/10.1080/10426500701735452
https://doi.org/10.1080/10426500701735452
Publikováno v:
Tetrahedron Letters. 45:8003-8006
Reactions of cyclic phosphate triesters, such as 2-ethoxy-1,3,2-dioxaphospholane 2-oxide, with Grignard reagents such as phenyl-, alkyl-, ethynyl-, and allyl-magnesium halides result in ring opening leading to the corresponding phosphonates, via nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c977161db7137e0ad3b51d0b11de1b9
https://doi.org/10.1016/j.tetlet.2004.09.011
https://doi.org/10.1016/j.tetlet.2004.09.011
Publikováno v:
Toxicological Sciences. 76:131-137
Potent cannabinoid CB1 receptor ligands include anandamide [N-(2-hydroxyethyl)arachidonamide], Delta9-tetrahydrocannabinol, and 3H-CP 55,940 at the agonist site and selected organophosphorus esters (including some pesticides) and organosulfur compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155306965a2ac2d877eca465dc7099df
https://doi.org/10.1093/toxsci/kfg216
https://doi.org/10.1093/toxsci/kfg216
Publikováno v:
Synthetic Communications. 33:2151-2159
Preparations of isopropyl dodec-11-enylfluorophosphonate and dodec-11-enesulfonyl fluoride are described along with conditions for their reduction with hydrogen (or potentially tritium) gas to the 1-dodecane derivatives as candidate high-potency (IC5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d72047cdc3a311b7ac9513ffc6708b0
https://doi.org/10.1081/scc-120021043
https://doi.org/10.1081/scc-120021043
Publikováno v:
Toxicology Letters. 135:89-93
Binding of the endocannabinoid anandamide or of Delta(9)-tetrahydrocannabinol to the agonist site of the cannabinoid receptor (CB1) is commonly assayed with [3H]CP 55,940. Potent long-chain alkylfluorophosphonate inhibitors of agonist binding suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d790c209a433586c4951eb3e3d09d68e
https://doi.org/10.1016/s0378-4274(02)00251-5
https://doi.org/10.1016/s0378-4274(02)00251-5
Publikováno v:
Toxicology and Applied Pharmacology. 179:57-63
Fatty acid amide hydrolase (FAAH) plays an important role in nerve function by regulating the action of endocannabinoids (e.g., anandamide) and hydrolyzing a sleep-inducing factor (oleamide). Several organophosphorus pesticides and related compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb60addad38b757c4601041a4f7c7aba
https://doi.org/10.1006/taap.2001.9342
https://doi.org/10.1006/taap.2001.9342
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 173:1-25
Eleven new bisphosphonates were prepared from naturally-occurring 1-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47efe551f6721d01d273239f1d93c3c
https://doi.org/10.1080/10426500108045257
https://doi.org/10.1080/10426500108045257
Autor:
Arie Ordentlich, Baruch Velan, Dov Barak, Naomi Ariel, Yoffi Segall, Chanoch Kronman, Avigdor Shafferman
Publikováno v:
Journal of Biological Chemistry. 273:19509-19517
The contribution of the oxyanion hole to the functional architecture and to the hydrolytic efficiency of human acetylcholinesterase (HuAChE) was investigated through single replacements of its elements, residues Gly-121, Gly-122 and the adjacent resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a4a4616666d4e7159bff78ec3ed4a9
https://doi.org/10.1074/jbc.273.31.19509
https://doi.org/10.1074/jbc.273.31.19509