Zobrazeno 1 - 10
of 286
pro vyhledávání: '"Yoel Kloog"'
Autor:
Anna Altshuler, Mila Verbuk, Swarnabh Bhattacharya, Ifat Abramovich, Roni Haklai, Jacob H. Hanna, Yoel Kloog, Eyal Gottlieb, Ruby Shalom-Feuerstein
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1088-1101 (2018)
Summary: The transition from naive to primed state of pluripotent stem cells is hallmarked by epithelial-mesenchymal transition, metabolic switch from oxidative phosphorylation to aerobic glycolysis, and changes in the epigenetic landscape. Since the
Externí odkaz:
https://doaj.org/article/84b6d54db5d242eea599bf123a8aace7
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 12, Pp 1-12 (2015)
Abstract Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose relative abundances regulate critical cellular processes. It is therefore essential that inclusion levels of alternative exons be tightly regulated. How
Externí odkaz:
https://doaj.org/article/a1c194120e6f41bcaba977fca767eee0
Autor:
Morad Zayoud, Victoria Marcu-Malina, Einav Vax, Jasmine Jacob-Hirsch, Galit Elad-Sfadia, Iris Barshack, Yoel Kloog, Itamar Goldstein
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The Ras family of GTPases plays an important role in signaling nodes downstream to T cell receptor and CD28 activation, potentially lowering the threshold for T-cell receptor activation by autoantigens. Somatic mutation in NRAS or KRAS may cause a ra
Externí odkaz:
https://doaj.org/article/b38a5c37db0144778b6064454b2ed559
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171351 (2017)
High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras in
Externí odkaz:
https://doaj.org/article/bb519697f58c40e08bc4141b7692856b
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75269 (2013)
BackgroundThe ErbB receptors, Ras proteins and nucleolin are major contributors to malignant transformation. The pleiotropic protein nucleolin can bind to both Ras protein and ErbB receptors. Previously, we have demonstrated a crosstalk between Ras,
Externí odkaz:
https://doaj.org/article/ac663bc6081f4e80aea6b86f46b086a1
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60965 (2013)
Epithelial ovarian cancer (EOC) is usually discovered after extensive metastasis have developed in the peritoneal cavity. The ovarian surface is exposed to peritoneal fluid pressures and shear forces due to the continuous peristaltic motions of the g
Externí odkaz:
https://doaj.org/article/398fe7eb5d964197915ce8f3b7e9b4bd
Autor:
Yoram Nevo, Shlomit Aga-Mizrachi, Edva Elmakayes, Nurit Yanay, Keren Ettinger, Moran Elbaz, Zivia Brunschwig, Oshrat Dadush, Galit Elad-Sfadia, Roni Haklai, Yoel Kloog, Joab Chapman, Shimon Reif
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18049 (2011)
The Ras superfamily of guanosine-triphosphate (GTP)-binding proteins regulates a diverse spectrum of intracellular processes involved in inflammation and fibrosis. Farnesythiosalicylic acid (FTS) is a unique and potent Ras inhibitor which decreased i
Externí odkaz:
https://doaj.org/article/3e0e0395acd2471d8f1ed6eb1990aded
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21712 (2011)
BACKGROUND: Reduced glucose uptake due to insulin resistance is a pivotal mechanism in the pathogenesis of type 2 diabetes. It is also associated with increased inflammation. Ras inhibition downregulates inflammation in various experimental models. T
Externí odkaz:
https://doaj.org/article/97fe4f4683554d6d8f5261398eef4484
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27490 (2011)
Galectin-3 (Gal-3) and active (GTP-bound) K-Ras contribute to the malignant phenotype of many human tumors by increasing the rate of cell proliferation, survival, and migration. These Gal-3-mediated effects result from a selective binding to K-Ras.GT
Externí odkaz:
https://doaj.org/article/1e1de31198c14c4f97d8af92f14eeb40
Autor:
Barak Rotblat, Liron Belanis, Hong Liang, Roni Haklai, Galit Elad-Zefadia, John F Hancock, Yoel Kloog, Sarah J Plowman
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11991 (2010)
H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK. The specificity and magnitude of downstream activation is achieved by the spatio-temporal organization of the active H-
Externí odkaz:
https://doaj.org/article/fbdd193deaeb46c6887ac1cbb7e04925