Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yoel H. Sitbon"'
Autor:
Yoel H. Sitbon, Katarzyna Kazmierczak, Jingsheng Liang, Andrew J. Kloehn, Judith Vinod, Rosemeire Kanashiro-Takeuchi, Danuta Szczesna-Cordary
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110591- (2024)
Summary: We investigated the role of the N-terminus (residues 1–43) of the myosin essential light chain (N-ELC) in regulating cardiac function in hypertrophic (HCM-A57G) and restrictive (RCM-E143K) cardiomyopathy mice. Both models were cross-genoty
Externí odkaz:
https://doaj.org/article/db0fb018c04f49009768f6ee88a379bb
Autor:
Ryan J. Worthen, Jeffrey A. Lowell, S. Desse, A. Barreda-Diaz, Yoel H. Sitbon, Y. Cheng, Marta Pardo, S.F. Grieco
Publikováno v:
Neuroscience Research. 149:1-13
Insulin-like growth factor 2 (IGF2) is abundantly expressed in the central nervous system (CNS). Recent evidence highlights the role of IGF2 in the brain, sustained by data showing its alterations as a common feature across a variety of psychiatric a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ba19bc836035f176adf3e5e12e1546
https://doi.org/10.1016/j.neures.2018.10.012
https://doi.org/10.1016/j.neures.2018.10.012
Autor:
Rosemeire M. Kanashiro-Takeuchi, Katarzyna Kazmierczak, Jingsheng Liang, Lauro M. Takeuchi, Yoel H. Sitbon, Danuta Szczesna-Cordary
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 24; Pages: 15589
In this study, we aimed to investigate whether short-term and low-dose treatment with hydroxychloroquine (HCQ), an antimalarial drug, can modulate heart function in a preclinical model of dilated cardiomyopathy (DCM) expressing the D94A mutation in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e94ed9e0fbe95e23731fe78bd14de0
https://doi.org/10.3390/ijms232415589
https://doi.org/10.3390/ijms232415589
Publikováno v:
J Muscle Res Cell Motil
The activity of cardiac and skeletal muscles depends upon the ATP-coupled actin-myosin interactions to execute the power stroke and muscle contraction. The goal of this review article is to provide insight into the function of myosin II, the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71de65eeb900065c1cf3a23536c803a
https://doi.org/10.1007/s10974-019-09517-x
https://doi.org/10.1007/s10974-019-09517-x
Autor:
Jingsheng Liang, Katarzyna Kazmierczak, Francisca Diaz, Medhi Wangpaichitr, Danuta Szczesna-Cordary, Yoel H. Sitbon
Publikováno v:
The Journal of General Physiology
Using mutations associated with cardiomyopathy, Sitbon et al. study the transition between the super relaxed state of myosin and the disordered-relaxed state. Their findings suggest that the N terminus of myosin essential light chain controls the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b63d4e57338717c73d1f47f574114f
https://pubmed.ncbi.nlm.nih.gov/34014247
https://pubmed.ncbi.nlm.nih.gov/34014247
Autor:
Yuyan Cheng, Ryan J. Worthen, Yoel H. Sitbon, Richard S. Jope, Jeffrey A. Lowell, Eleonore Beurel
Publikováno v:
Trends in Biochemical Sciences. 42:180-192
Psychological stress has a pervasive influence on our lives. In many cases adapting to stress strengthens organisms, but chronic or severe stress is usually harmful. One surprising outcome of psychological stress is the activation of an inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09286fd6a643aa5cac1b3095edb3e166
https://doi.org/10.1016/j.tibs.2016.10.009
https://doi.org/10.1016/j.tibs.2016.10.009
Autor:
Jingsheng Liang, Melanie Veerasammy, Danuta Szczesna-Cordary, Sunil Yadav, Katarzyna Kazmierczak, Yoel H. Sitbon, Rosemeire M. Kanashiro-Takeuchi
Publikováno v:
FEBS J
In this study, we focus on the molecular mechanisms associated with the A57G (Ala57-to-Gly57) mutation in myosin essential light chains (ELCs), found to cause hypertrophic cardiomyopathy (HCM) in humans and in mice. Specifically, we studied the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a518c1738a48b2c6041ccd135ae95453
https://pubmed.ncbi.nlm.nih.gov/32034976
https://pubmed.ncbi.nlm.nih.gov/32034976
Myosin regulatory light chain (RLC) phosphorylation is important for cardiac muscle mechanics/function as well as for the Ca(2+)-troponin/tropomyosin regulation of muscle contraction. This study focuses on the arginine to glutamine (R58Q) substitutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf874c9e5f2a994e8e12ba7afae0cbf6
https://europepmc.org/articles/PMC6326841/
https://europepmc.org/articles/PMC6326841/
Autor:
Danuta Szczesna-Cordary, Katarzyna Kazmierczak, Melanie Veerasammy, Jingsheng Liang, Yoel H. Sitbon
Publikováno v:
Biophysical Journal. 118:328a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea9f3e45f06d7c4943ec4561a4cb4d4c
https://doi.org/10.1016/j.bpj.2019.11.1836
https://doi.org/10.1016/j.bpj.2019.11.1836
Autor:
Yoel H. Sitbon, Richard S. Jope, Eleonore Beurel, Ryan J. Worthen, Eva Medina, Jeffrey A. Lowell
Publikováno v:
Psychoneuroendocrinology. 71:53-54
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6de2d8644640b0f15de05926ff6159b
https://doi.org/10.1016/j.psyneuen.2016.07.141
https://doi.org/10.1016/j.psyneuen.2016.07.141