Design, Synthesis, and Biological Evaluation of Novel Spiro Imidazobenzodiazepines to Identify Improved Inhaled Bronchodilators.

Autor: Webb DA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Meyer MJ; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Medubi KM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Tylek AS; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Yocum GT; Department of Anesthesiology, Columbia University, New York, New York 10032, United States., Roni MSR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Swartwout SA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Masoud AK; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States., Emala CW; Department of Anesthesiology, Columbia University, New York, New York 10032, United States., Stafford DC; Pantherics Incorporated, La Jolla, California 92037, United States., Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.; Pantherics Incorporated, La Jolla, California 92037, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jul 27; Vol. 66 (14), pp. 9853-9865. Date of Electronic Publication: 2023 Jul 07.

Comparative pharmacodynamic and pharmacokinetic study of MIDD0301 and its (S) enantiomer.

Autor: Rashid Roni MS; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Zahn NM; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Yocum GT; Department of Anesthesiology, Columbia University, New York, New York, USA., Webb DA; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Mian MY; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Meyer MJ; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Tylek AS; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Cook JM; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA., Emala CW; Department of Anesthesiology, Columbia University, New York, New York, USA., Stafford DC; Pantherics Incorporated, La Jolla, California, USA., Arnold LA; Department of Chemistry and Biochemistry, and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.; Pantherics Incorporated, La Jolla, California, USA.

Publikováno v: Drug development research [Drug Dev Res] 2022 Jun; Vol. 83 (4), pp. 979-992. Date of Electronic Publication: 2022 Mar 04.

Nebulized MIDD0301 Reduces Airway Hyperresponsiveness in Moderate and Severe Murine Asthma Models.

Autor: Zahn NM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States., Mikulsky BN; Pantherics Incorporated, La Jolla, California 92037, United States., Roni MSR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States., Yocum GT; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States., Mian MY; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States., Knutson DE; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States., Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States., Emala CW; Department of Anesthesiology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States., Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States.; Pantherics Incorporated, La Jolla, California 92037, United States., Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, United States.; Pantherics Incorporated, La Jolla, California 92037, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2020 Dec 02; Vol. 3 (6), pp. 1381-1390. Date of Electronic Publication: 2020 Dec 02 (Print Publication: 2020).

Agonism of the TMEM16A calcium-activated chloride channel modulates airway smooth muscle tone.

Autor: Danielsson J; Department of Anesthesiology, Columbia University, New York, New York., Kuforiji AS; Department of Anesthesiology, Columbia University, New York, New York., Yocum GT; Department of Anesthesiology, Columbia University, New York, New York., Zhang Y; Department of Anesthesiology, Columbia University, New York, New York., Xu D; Department of Anesthesiology, Columbia University, New York, New York., Gallos G; Department of Anesthesiology, Columbia University, New York, New York., Emala CW Sr; Department of Anesthesiology, Columbia University, New York, New York.

Publikováno v: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2020 Feb 01; Vol. 318 (2), pp. L287-L295. Date of Electronic Publication: 2019 Nov 20.

High throughput screening of airway constriction in mouse lung slices.

Autor: Boucher, Magali¹, Henry, Cyndi¹, Gélinas, Louis¹, Packwood, Rosalie¹, Rojas-Ruiz, Andrés¹, Fereydoonzad, Liah², Graham, Percival², Bossé, Ynuk¹ ynuk.bosse@criucpq.ulaval.ca

Publikováno v: Scientific Reports. 8/29/2024, Vol. 14 Issue 1, p1-12. 12p.