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Akademický článek

Neoantigens in cancer immunotherapy: quantity vs. quality

Publikováno v: Molecular Oncology, Vol 17, Iss 8, Pp 1457-1459 (2023)

Traditional immunotherapies provide clinical benefits to only a few patients with solid tumors, highlighting the urgent need for more effective approaches. Traditional immunotherapies rely on the presentation of cancer antigens, with neoantigens bein

Externí odkaz: https://doaj.org/article/8a84f98f392e42ecbedfc3a9a7d09d6a

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Akademický článek

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Autor: Dorothy P Schafer, Christopher T Heller, Georgia Gunner, Molly Heller, Christopher Gordon, Timothy Hammond, Yochai Wolf, Steffen Jung, Beth Stevens

Publikováno v: eLife, Vol 5 (2016)

Microglia, the resident CNS macrophages, have been implicated in the pathogenesis of Rett Syndrome (RTT), an X-linked neurodevelopmental disorder. However, the mechanism by which microglia contribute to the disorder is unclear and recent data suggest

Externí odkaz: https://doaj.org/article/cfbe4addb0a54107a8ffbafde3673367

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Akademický článek

Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

Autor: Adi Gilboa-Geffen, Yochai Wolf, Geula Hanin, Naomi Melamed-Book, Marjorie Pick, Estelle R Bennett, David S Greenberg, Susan Lester, Maureen Rischmueller, Hermona Soreq

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28727 (2011)

The purpose of our study was to understand if Toll-like receptor 9 (TLR9) activation could contribute to the control of inflammation in Sjogren's syndrome. To this end, we manipulated TLR9 signaling in non-obese diabetic (NOD) and TLR9(-/-) mice usin

Externí odkaz: https://doaj.org/article/738cb2a18b1149fca36a75e04b8ee92c

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