Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yoav Shetzer"'
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
Supplementary Figure 1. Mutant p53 enhanced the self-renewal capacity and oncogenicity of primary bone marrow MSCs. Supplementary Figure 2. Mutant p53 MSC derived tumor lines exhibited augmented tumorigenic capacity compared with their parental cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b015d543ce7c7bcb7583e88b441aed
https://doi.org/10.1158/0008-5472.22419564.v1
https://doi.org/10.1158/0008-5472.22419564.v1
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
Differential expression of the p53 Mut MSC TL ESC signature and mutant dependent ESC genes in human tumors harboring mutant p53 missense mutations versus the rest of tumor samples. This analysis was based on datasets provided by TCGA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b72864f09d03a3afee0b58eceee8932
https://doi.org/10.1158/0008-5472.22419546
https://doi.org/10.1158/0008-5472.22419546
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer. These mutations include p53-inactivating mutations as well as oncogenic gain-of-function (GOF) mutations that endow p53 with capabilities to promote tumor progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d41576fd7bb5ba641213109f87a9e09d
https://doi.org/10.1158/0008-5472.c.6510411.v1
https://doi.org/10.1158/0008-5472.c.6510411.v1
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
Differential genes between p53 Mut MSC TL and KO MSC TL sub-clones. The table contains genes that had at least 10 reads in the RNA sequencing analysis. p53 Mut MSC TL ESC-like genes, ESC genes and PRC2 target genes are indicated and can be filtered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a214a56ee09f8adda80d50c7f49f82d
https://doi.org/10.1158/0008-5472.22419555
https://doi.org/10.1158/0008-5472.22419555
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
IPA analysis of the differential genes between pMSCs and their derived TLs (MSC TLs). Biological function was determined for the genes that were downregulated in p53 Mut MSC TLs compared to their parental, p53 Mut pMSC. Biological function, Pathways,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66150560f7995fce6b5f48ab8daf9d91
https://doi.org/10.1158/0008-5472.22419558
https://doi.org/10.1158/0008-5472.22419558
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
Differential genes between pMSCs and their derived TLs (MSC TLs). The table contains genes that had at least 10 reads in the RNA sequencing analysis. CSC genes, ESC genes, shared target genes of Nanog, Sox2 and Oct4 or of Nanog, Sox2, Oct4, Dax1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4187154d4ca2daef21584e30e194a43a
https://doi.org/10.1158/0008-5472.22419561
https://doi.org/10.1158/0008-5472.22419561
Autor:
Varda Rotter, Naomi Goldfinger, Giuseppe Lonetto, Alina Molchadsky, Ron Rotkopf, Hilla Solomon, Shay Eizenberger, Yoav Shetzer, Gabriela Koifman
IPA analysis of the differential genes between p53 Mut MSC TL and KO MSC TL sub-clones. Biological functions and pathway analysis were determined for the upregulated and downregulated genes following p53 Mut KO. (The threshold of significant genes; p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4bbe1357c1c85c654043952be7045c
https://doi.org/10.1158/0008-5472.22419552
https://doi.org/10.1158/0008-5472.22419552
Autor:
Hilla Solomon, Yoav Shetzer, Ron Rotkopf, Shay Eizenberger, Naomi Goldfinger, Varda Rotter, Alina Molchadsky, Giuseppe Lonetto, Gabriela Koifman
Publikováno v:
Cancer Research. 78:5833-5847
Mutations in the tumor suppressor p53 are the most frequent alterations in human cancer. These mutations include p53-inactivating mutations as well as oncogenic gain-of-function (GOF) mutations that endow p53 with capabilities to promote tumor progre
Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers
Autor:
Ziv Porat, Varda Rotter, Stav Rabani, Alina Molchadsky, Tomer Cooks, Nathan Dinowitz, Hilla Solomon, Yoav Shetzer, Ira Kogan-Sakin, Vassilis G. Gorgoulis, Naomi Goldfinger, Moshe Oren, Ohad Tarcic, Meital Charni, Gabriela Koifman, Curtis C. Harris, Ioannis S. Pateras
Publikováno v:
Oncogene
Emerging notion in carcinogenesis ascribes tumor initiation and aggressiveness to cancer stem cells (CSCs). Specifically, colorectal cancer (CRC) development was shown to be compatible with CSCs hypothesis. Mutations in p53 are highly frequent in CRC
Autor:
Varda Rotter, Tom Kaufman, Alina Molchadsky, Yael Napchan, Naomi Goldfinger, Yoav Shetzer, Perry Tal
Publikováno v:
International Journal of Cancer. 140:1364-1369
p53 loss of heterozygosity (LOH) is a frequent event in tumors of somatic and Li-Fraumeni syndrome patients harboring p53 mutation. Here, we focused on resolving a possible crosstalk between the immune-system and p53 LOH. Previously, we reported that