Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yoav E. Timsit"'
Autor:
Yoav E Timsit, Masahiko Negishi
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96092 (2014)
The constitutive active/androstane receptor (CAR) plays an important role as a coordinate transcription factor in the regulation of various hepatic metabolic pathways for chemicals such as drugs, glucose, fatty acids, bilirubin, and bile acids. Curre
Externí odkaz:
https://doaj.org/article/96ef23f5d40e41e590629a496556be72
Autor:
Yinuo Pang, Gaetane Woerly, Esther Sutter, Francois Pognan, Ursula Schramm, Yoav E Timsit, Marie Anne Valentin, Philippe Couttet, Armin Wolf, Beate Vogel, Ivan Demin, Birgit Jaitner, Ronenn Roubenoff
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 369(3)
The colony-stimulating factor-1 (CSF-1) receptor pathway has been implicated in a variety of diseases, and CSF-1-dependent mechanisms are also involved in bloodborne protein clearance. Lacnotuzumab is a novel, high-affinity, humanized, anti-CSF-1 mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef69e48a10a90d3ac1e1ed0857b5eac9
https://pubmed.ncbi.nlm.nih.gov/30894455
https://pubmed.ncbi.nlm.nih.gov/30894455
Autor:
Yoav E. Timsit, Masahiko Negishi
Publikováno v:
Steroids. 72:231-246
The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their eliminati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08b5229b02147ccce5fc39c97fc82a6
https://doi.org/10.1016/j.steroids.2006.12.006
https://doi.org/10.1016/j.steroids.2006.12.006
Autor:
Edward T. Morgan, Chunja Lee, Po-Yung Cheng, Kristy K. Michael Miller, John Y.L. Chiang, Russell A. Prough, David S. Riddick, Asmeen Jahan, Yoav E. Timsit, Sharon L. Ripp, Anahita Bhathena
Publikováno v:
Drug Metabolism and Disposition. 32:367-375
This article is an invited report of a symposium sponsored by the Division for Drug Metabolism of the American Society for Pharmacology and Experimental Therapeutics held at Experimental Biology 2003 in San Diego, California, April 11-15, 2003. Sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7083737921ce6e79ffc466210ca416f1
https://doi.org/10.1124/dmd.32.4.367
https://doi.org/10.1124/dmd.32.4.367
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 81:59-77
Most responses to aromatic hydrocarbons such as 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by the aromatic hydrocarbon receptor (AHR). The AHR regulates induction of drug-metabolizing enzymes such as cytochrome P45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9018506bc64249a4a0c972a439e45e6c
https://doi.org/10.1139/y03-003
https://doi.org/10.1139/y03-003
Autor:
Yoav E. Timsit, David S. Riddick
Publikováno v:
Toxicology and Applied Pharmacology. 163:105-114
Cytochrome P450 2C11 (CYP2C11) is a sexually dimorphic liver enzyme whose expression is regulated by the male pulsatile pattern of growth hormone (GH) secretion. Hepatic CYP2C11 expression is down-regulated by polycyclic aromatic hydrocarbons such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098efd40f2d7667e97f73c1247609674
https://doi.org/10.1006/taap.1999.8862
https://doi.org/10.1006/taap.1999.8862
Publikováno v:
Biochemical and biophysical research communications. 328(2)
Epsin is an endocytic adaptor protein involved in the regulation of clathrin-dependent endocytosis. We and others have demonstrated that Epsin is ubiquitylated in cells and requires its ubiquitin interacting motifs (UIMs) for this modification. To fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635a2356358cb0d633b930fb05250ba5
https://pubmed.ncbi.nlm.nih.gov/15694383
https://pubmed.ncbi.nlm.nih.gov/15694383
Autor:
Yoav E. Timsit, David S. Riddick
Publikováno v:
Endocrinology. 143(9)
We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene expression. CYP2C11 is an enzyme expressed in the liver of male rats and is regulated by a pul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5d1a2b0e9ff41418c65971bc7cebeb
https://pubmed.ncbi.nlm.nih.gov/12193540
https://pubmed.ncbi.nlm.nih.gov/12193540
Autor:
Anthony Boral, Salah-Dine Chibout, Nancy Turner, Yoav E Timsit, Thomas Krucker, Silvia Buonamici, Francois Pognan, Aaron L Nelson, Diane E. Gunson, Dereck Amakye, Judit Markovits
Publikováno v:
Journal of Clinical Oncology. 30:9562-9562
9562 Background: The Hedgehog pathway plays an important role in regulating growth plate patency by activating PTH/PTHrP signaling, and loss of PTH/PTHrP signaling is an expected pharmacological effect of smoothened (Smo) inhibition. LDE225, a Smo in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e52a4d214114d8511947ef06f6bb746
https://doi.org/10.1200/jco.2012.30.15_suppl.9562
https://doi.org/10.1200/jco.2012.30.15_suppl.9562
Autor:
Masahiko Negishi, Rick Moore, Fardin Hosseinpour, Kenji Matsui, Chika Koike, Yoav E. Timsit, Yukio Yamamoto
Publikováno v:
FEBS Letters. (25):4937-4942
Various drugs such as phenobarbital (PB) trigger translocation of constitutive active/adrostane receptor (CAR) from the cytoplasm into the nucleus of mouse liver cells without directly binding to the receptor. We have now characterized the guanine nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7c5ac6dc3f3d7d4c033aca7498c6b1