Human Aortic Valve Interstitial Cells Display Proangiogenic Properties During Calcific Aortic Valve Disease

Autor: R. Jashari, Séverine Lecourt, Sophie Susen, Pascale Gaussem, Eric Van Belle, Nicolas Gendron, Bernard Cholley, André Vincentelli, Nathalie Nevo, Elisa Rossi, Richard Chocron, David M. Smadja, Bart Staels, Annabelle Dupont, Salim Idelcadi, Mickael Rosa, Audrey Cras, Ivan Bièche, Jeanne Rancic, Yoann Sottejeau, Thibault Pamart, Yaël Baudouin, Alain Carpentier, Adeline Blandinières

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology.

Objective: The study’s aim was to analyze the capacity of human valve interstitial cells (VICs) to participate in aortic valve angiogenesis. Approach and Results: VICs were isolated from human aortic valves obtained after surgery for calcific aorti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11818907ea133458a95bb7425a1fa1b5
https://doi.org/10.1161/atvbaha.120.314287

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways

Autor: André Vincentelli, Yoann Sottejeau, Francis Juthier, Annabelle Dupont, Madjid Tagzirt, Mickael Rosa, Bart Staels, Delphine Corseaux, Eric Van Belle, Sophie Susen, Camille Paris, R. Jashari, Antoine Rauch, Emmanuel Robin

Publikováno v: Acta Diabetologica. 54:551-560

Calcific aortic valve disease (CAVD) affects 2–6% of the population over 65 years, and age, gender, smoking, overweight, dyslipidemia, diabetes contribute to the development of this disease. CAVD results, in part, from the osteoblast differentiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee99b3e50137c51cbb3fa51d0736655
https://doi.org/10.1007/s00592-017-0980-3

Valvular interstitial cells down regulate matrix metalloproteinase 9 activity and expression in human monocyte-derived macrophages: Potential impact on aortic valve stenosis pathophysiology

Autor: Madjid Tagzirt, Sophie Susen, André Vincentelli, Yoann Sottejeau, Bart Staels, R. Mickael, R. Jashari, Delphine Corseaux, Francis Juthier, S. Kabdani, Annabelle Dupont, E. Van Belle

Publikováno v: Archives of Cardiovascular Diseases Supplements. 11:248

Introduction Aortic valve stenosis (AVS) involves inflammation, excess deposition of collagen-rich extracellular matrix (ECM) and calcification. Recent studies have shown that M1 macrophages observed in stenosed valve promote calcification of valvula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::337e60536956d47564c8c61692d394ec
https://doi.org/10.1016/j.acvdsp.2019.02.143

ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease

Autor: Pierre Dourlen, Yves Lemoine, Amandine Flaig, Frédéric Checler, Anne Marie Ayral, Jean-Charles Lambert, Kris Gevaert, Mathias Laga, Fanny Eysert, Tiago Mendes, David M. A. Mann, Linda Chami, Anne Sophie Hérard, Thierry Delzescaux, Franck Lafont, Florie Demiautte, Franck Hansmannel, Benoit Deprez, Charlotte Delay, David Hot, Florence Leroux, Bart Dermaut, Philippe Amouyel, Ludovic Huot, Yoann Sottejeau, Florence Pasquier, Nicolas Souedet, Florent Letronne, Charlotte Bauer, Marc Dhenain, Marie Lesaffre, Geoffroy Laumet, Nicolas Malmanche, David Tulasne, Claudine Berr, Rebecca Deprez, Julie Dumont, Elisabeth Werkmeister, Michel E. Vandenberghe, Jean Jacques Hauw, Julien Chapuis

Publikováno v: EBioMedicine
EBioMedicine, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
Letronne, F, Laumet, G, Ayral, A-M, Chapuis, J, Demiautte, F, Laga, M, Vandenberghe, M, Malmanche, N, Leroux, F, Eysert, F, Sottejeau, Y, Chami, L, Flaig, A, Bauer, C, Dourlen, P, Lesaffre, M, Delay, C, Huot, L, Dumont, J, Werkmeister, E, Lafont, F, Mendes, T, Hansmannel, F, Dermaut, B, Deprez, B, Hérard, A-S, Dhenain, M, Souedet, N, Pasquier, F, Tulasne, D, Berr, C, Hauw, J-J, Lemoine, Y, Amouyel, P, Mann, D, Déprez, R, Checler, F, Hot, D, Delzescaux, T, Gevaert, K & Lambert, J-C 2016, ' ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2016.06.002
EBioMedicine, Elsevier, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)
EBIOMEDICINE

Although several ADAMs (A disintegrin-like and metalloproteases) have been shown to contribute to the amyloid precursor protein (APP) metabolism, the full spectrum of metalloproteases involved in this metabolism remains to be established. Transcripto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9bf8d295c4426a333c53668484f520
https://pubmed.ncbi.nlm.nih.gov/27333034

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

Autor: M-C Galas, Yoann Sottejeau, Hélène Obriot, Cloé Dupont, F Abdelfettah, Alexis Bretteville, Raphaëlle Caillierez, Benjamin Grenier-Boley, Nicolas Malmanche, Pierre Dourlen, Nicolas Sergeant, Bart Dermaut, Julien Chapuis, Charlotte Delay, Francisco-Jose Fernandez-Gomez, Luc Buée, Hilkka Soininen, Mikko Hiltunen, P. Amouyel, Céline Bellenguez, J-C Lambert

Publikováno v: Molecular Psychiatry
MOLECULAR PSYCHIATRY

A recent genome-wide association meta-analysis for Alzheimer’s disease (AD) identified 19 risk loci (in addition to APOE) in which the functional genes are unknown. Using Drosophila, we screened 296 constructs targeting orthologs of 54 candidate ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cf6d1b220eabe8b358f72c230764ae
https://pubmed.ncbi.nlm.nih.gov/27113998