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Pennogenin-3-O-α-L-Rhamnopyranosyl-(1→2)-[α-L-Rhamnopyranosyl-(1→3)]-β-D-Glucopyranoside (Spiroconazol A) Isolated from Dioscorea bulbifera L. var. sativa Induces Autophagic Cell Death by p38 MAPK Activation in NSCLC Cells

Autor: Yo Sook Ki, Kyung-Sook Chung, Heon-Woo Lee, Jung-Hye Choi, Léon Azefack Tapondjou, Eungyeong Jang, Kyung-Tae Lee

Publikováno v: Pharmaceuticals, Vol 15, Iss 7, p 893 (2022)

In our previous study, we reported the isolation of pennogenin-3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (spiroconazol A), a steroidal saponin, from the flowers of Dioscorea bulbifera L. var. sativa. In the

Externí odkaz: https://doaj.org/article/6da38eabf75a4b47b6669ac8e7ae2e6f

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Donepezil, a Potent Acetylcholinesterase Inhibitor, Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

Autor: Eun-Young Park, Heon-Woo Lee, Yo Sook Ki, Kyung-Tae Lee, Myung Sook Oh, Ji Hee Moon, Yunhee Kim Kwon, Young-Wuk Cho

Publikováno v: Biological and Pharmaceutical Bulletin. 33:1054-1059

Although donepezil, a potent acetylcholinesterase (AChE) inhibitor, has been used to treat Alzheimer's disease (AD) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. In the present stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc263ae74446745b80e8f39ecef7879
https://doi.org/10.1248/bpb.33.1054

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3.ALPHA.,23-Isopropylidenedioxyolean-12-en-27-oic Acid, a Triterpene Isolated from Aceriphyllum rossii, Induces Apoptosis in Human Cervical Cancer HeLa Cells through Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Autor: Yo Sook Ki, Kyung-Sook Chung, So-Jung Won, Kyung-Tae Lee, Jung-Hye Choi, KiHwan Bae

Publikováno v: Biological and Pharmaceutical Bulletin. 33:1620-1626

In the present study, we investigated the effect of 3alpha,23-isopropylidenedioxyolean-12-en-27-oic acid (IPA), an active compound isolated from Aceriphyllum rossii, on the apoptotic activity and the molecular mechanism of the action in human cervica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44898c9001806e7cc130ec61ece99c5f
https://doi.org/10.1248/bpb.33.1620

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ChemInform Abstract: CWJ-081 (I), a Novel 3-Arylisoquinoline Derivative, Induces Apoptosis in Human Leukemia HL-60 Cells Partially Involves Reactive Oxygen Species Through c-Jun NH2-Terminal Kinase Pathway

Autor: Jung-Hye Choi, Kyung-Sook Chung, So-Jung Won, Yo Sook Ki, Cho Won Jea, Kyung-Tae Lee

Publikováno v: ChemInform. 42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2af0eb5ab3ef33eadfa801bc56030635
https://doi.org/10.1002/chin.201108159

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CWJ-081, a novel 3-arylisoquinoline derivative, induces apoptosis in human leukemia HL-60 cells partially involves reactive oxygen species through c-Jun NH2-terminal kinase pathway

Autor: Jung-Hye Choi, So-Jung Won, Kyung-Sook Chung, Kyung-Tae Lee, Yo Sook Ki, Won-Jea Cho

Publikováno v: Bioorganicmedicinal chemistry letters. 20(22)

In the present study, we investigated the effect of a novel 3-arylisoquinoline derivative 3-(6-ethyl-benzo[1,3]dioxol-5-yl)-7,8-dimethoxy-2-methyl-2H-isoquinolin-1-one (CWJ-081) on the induction of apoptosis and the putative molecular mechanism of it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34780fa7090c6facf6c4825b522bc489
https://pubmed.ncbi.nlm.nih.gov/20932751

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