Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Yo Ichi Wada"'
Autor:
Shoichi Ishiura, Minoru Saitoe, Mei-Ling Qi, Yo-ichi Wada, Yasushi Enokido, Ichiro Kanazawa, Kei Watase, Erich E. Wanker, Natsue Yoshimura, Hitoshi Okazawa, Kazuhiko Tagawa, Juan Botas
Publikováno v:
Nature Cell Biology. 9(No. 4):402-14
Nuclear dysfunction is a key feature of the pathology of polyglutamine (polyQ) diseases. It has been suggested that mutant polyQ proteins impair functions of nuclear factors by interacting with them directly in the nucleus. However, a systematic anal
Autor:
Shigeki Marubuchi, Ichiro Kanazawa, Giovanni Blandino, Marius Sudol, Kiyomitsu Oyanagi, Masataka Hoshino, Minoru Saitoe, Tomoyuki Miyashita, Mei Ling Qi, Natsue Yoshimura, Kazuhiko Tagawa, Hitoshi Okazawa, Yasushi Enokido, Tina Rich, Yo Ichi Wada, Phoebe Harjes, Erich E. Wanker, Nobutaka Arai
Publikováno v:
The Journal of Cell Biology
Transcriptional disturbance is implicated in the pathology of polyglutamine diseases, including Huntington's disease (HD). However, it is unknown whether transcriptional repression leads to neuronal death or what forms that death might take. We found
Autor:
Ichiro Kanazawa, Yunglong Qi, Yo-ichi Wada, Kenichi Shinomiya, Natsue Yoshimura, Masataka Hoshino, Shigeki Marubuchi, Hitoshi Okazawa
Publikováno v:
European Journal of Neuroscience. 22:1277-1286
Summary Mutations of PQBP-1 (polyglutamine binding protein-1) have been shown recently to cause human mental retardation accompanied by microcephaly at a high frequency. As a first step towards understanding the molecular basis of this developmental
Autor:
Yunglong, Qi, Masataka, Hoshino, Yo-ichi, Wada, Shigeki, Marubuchi, Natsue, Yoshimura, Ichiro, Kanazawa, Ken-ichi, Shinomiya, Hitoshi, Okazawa
Publikováno v:
The European journal of neuroscience. 22(6)
Mutations of PQBP-1 (polyglutamine binding protein-1) have been shown recently to cause human mental retardation accompanied by microcephaly at a high frequency. As a first step towards understanding the molecular basis of this developmental anomaly,
Autor:
Shigeki Marubuchi, Mei-Ling Qi, Masaya Nakagawa, Hitoshi Okazawa, Masataka Hoshino, Yo-ichi Wada, Yukiko Hara, Tomohiro Okuda, Ichiro Kanazawa
Publikováno v:
Journal of neurochemistry. 95(3)
Polyglutamine tract-binding protein-1 (PQBP-1) is a nuclear protein that interacts and colocalizes with mutant polyglutamine proteins. We previously reported that PQBP-1 transgenic mice show a late-onset motor neuron disease-like phenotype and cell d