Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ylva Gravenfors"'
Autor:
Christoffer Bengtsson, Ylva Gravenfors
Publikováno v:
Molecules, Vol 28, Iss 12, p 4818 (2023)
The construction of duocarmycin-like compounds is often associated with lengthy synthetic routes. Presented herein is the development of a short and convenient synthesis of a type of duocarmycin prodrug. The 1,2,3,6-tetrahydropyrrolo[3,2-e]indole-con
Externí odkaz:
https://doaj.org/article/0d5e4ca584234c7a8cad35fabbee579a
Autor:
Andreas Luttens, Hjalmar Gullberg, Eldar Abdurakhmanov, Duy Duc Vo, Dario Akaberi, Vladimir O. Talibov, Natalia Nekhotiaeva, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Janina Krambrich, Ali Tas, Bo Lundgren, Ylva Gravenfors, Alexander J. Craig, Yoseph Atilaw, Anja Sandström, Lindon W. K. Moodie, Åke Lundkvist, Martijn J. van Hemert, Johan Neyts, Johan Lennerstrand, Jan Kihlberg, Kristian Sandberg, U. Helena Danielson, Jens Carlsson
Publikováno v:
Journal of the American Chemical Society, 144(7), 2905-2920. AMER CHEMICAL SOC
Drugs targeting SARS-CoV-2 could have saved millions of lives during the COVID-19 pandemic, and it is now crucial to develop inhibitors of coronavirus replication in preparation for future outbreaks. We explored two virtual screening strategies to fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946c3c3e10aa0c690988b970c049d161
http://hdl.handle.net/1887/3479854
http://hdl.handle.net/1887/3479854
Autor:
Britt-Marie Swahn, Ylva Gravenfors, Gunnar Nordvall, Jenny Viklund, Fredrik Rahm, Karin Kolmodin, Mats Svensson
Publikováno v:
ACS Medicinal Chemistry Letters. 5:440-445
In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. De novo design of core fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885dc56bda6538e85c3fe554c7e2c1f6
https://doi.org/10.1021/ml5000433
https://doi.org/10.1021/ml5000433
Autor:
Tobias Ginman, Elisabet Venyike, Tjerk Bueters, Istvan Macsari, Lars Sandberg, Anders B. Eriksson, Yevgeni Besidski, Ylva Gravenfors, Per-Eric Lund, Johan Bylund, Per I. Arvidsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3871-3876
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective Na(V)1.7 blocker. Structural analogues of 1, both carbamates, urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a598771737ba14364d0d2106e09e6409
https://doi.org/10.1016/j.bmcl.2011.05.041
https://doi.org/10.1016/j.bmcl.2011.05.041
Autor:
Jenny Viklund, Ylva Gravenfors, Fredrik Jeppsson, Anders E. G. Lindgren, Anh Johansson, Jonas Malmström, Jan Blid, Karin J. Sterky, Annika Kers, Rickard Forsblom, Rikard Emond, Johanna Fälting, Tobias Ginman, Fredrik Rahm, Patrik Johansson, Margareta Bergh, Fredrik Lake, Fernando Sehgelmeble
Publikováno v:
Journal of medicinal chemistry. 56(11)
By use of iterative design aided by predictive models for target affinity, brain permeability, and hERG activity, novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the goal of finding BACE-1 inhibitors as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28939a6aa8f37799fef11079a09af60e
https://pubmed.ncbi.nlm.nih.gov/23126626
https://pubmed.ncbi.nlm.nih.gov/23126626
Autor:
Ylva, Gravenfors, Jenny, Viklund, Jan, Blid, Tobias, Ginman, Sofia, Karlström, Jacob, Kihlström, Karin, Kolmodin, Johan, Lindström, Stefan, von Berg, Fredrik, von Kieseritzky, Krisztian, Bogar, Can, Slivo, Britt-Marie, Swahn, Lise-Lotte, Olsson, Patrik, Johansson, Susanna, Eketjäll, Johanna, Fälting, Fredrik, Jeppsson, Kia, Strömberg, Juliette, Janson, Fredrik, Rahm
Publikováno v:
Journal of medicinal chemistry. 55(21)
Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and structure–activity relationships for target activity, permeability, and hERG activity are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e0ec2c24a4566dacbf31db9c6264bc
https://pubmed.ncbi.nlm.nih.gov/23017051
https://pubmed.ncbi.nlm.nih.gov/23017051
Autor:
Johan Bylund, Daniel Sohn, Jan Blid, Yevgeni Besidski, Ismet Dorange, Mats Svensson, Rickard Forsblom, Ylva Gravenfors, Istvan Macsari
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(22)
A novel indolizine class of compounds was identified as TRPV1 antagonist from an HTS campaign. However, this indolizine class proved to be unstable and reacted readily with glutathione when exposed to light and oxygen. Reactivity was reduced by the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54149edab698d5a6814f182127291414
https://pubmed.ncbi.nlm.nih.gov/23058884
https://pubmed.ncbi.nlm.nih.gov/23058884
Autor:
Sofie Nyström, Elin Hagstrom, Camilla Dahlqvist, Johan Lundkvist, Ylva Gravenfors, Urban Karlsson, Rolf Olsson, Per Hammarström, Sylvia Simon, Ann-Cathrin Radesäter, Gunnar Nordvall, Samuel P.S. Svensson
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3cbd8daf50dbea957247451492cad27
https://doi.org/10.1016/j.jalz.2011.05.1109
https://doi.org/10.1016/j.jalz.2011.05.1109
Autor:
Jacob Kihlström, Johan Lindström, Fredrik Jeppsson, Johanna Fälting, Can Slivo, Tobias Ginman, Susanna Eketjäll, Jenny Viklund, Fredrik Rahm, Patrik Johansson, Jan Blid, Britt-Marie Swahn, Juliette Janson, Karin Kolmodin, Ylva Gravenfors, Krisztián Bogár, Stefan von Berg, Lise-Lotte Olsson, Kia Strömberg, Fredrik von Kieseritzky, Sofia Karlström
Publikováno v:
Journal of Medicinal Chemistry. 55:10316-10316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1081d06fc452e5b5f2bc8f7c0e42dc
https://doi.org/10.1021/jm301629c
https://doi.org/10.1021/jm301629c
Autor:
Per H. Svensson, Satish Srinivas Kitambi, Patrik Ernfors, Rune Ringom, Alexandra Bernlind, David Wennman, Mikael Granath, Lars Hammarström, Robert K. Harmel, Ylva Gravenfors, Fredrik Lehmann, Ylva Roddis, Katarina Färnegårdh, Göran Lundin
Publikováno v:
Journal of Medicinal Chemistry
Glioblastoma remains an incurable brain cancer. Drugs developed in the past 20 years have not improved the prognosis for patients, necessitating the development of new treatments. We have previously reported the therapeutic potential of the quinoline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff09203c2f0fd3f9f34cf8c5f7bab3e7