Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ylli Doksani"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Homologous recombination factors play a crucial role in protecting nascent DNA during DNA replication, but the role of chromatin in this process is largely unknown. Here, we used the bacterial Tus/Ter barrier known to induce a site-specific
Externí odkaz:
https://doaj.org/article/d6321b2b786b46ffb42d93461f25bb0a
Autor:
Lorenza Garribba, Giuseppina De Feudis, Valentino Martis, Martina Galli, Marie Dumont, Yonatan Eliezer, René Wardenaar, Marica Rosaria Ippolito, Divya Ramalingam Iyer, Andréa E. Tijhuis, Diana C. J. Spierings, Michael Schubert, Silvia Taglietti, Chiara Soriani, Simon Gemble, Renata Basto, Nick Rhind, Floris Foijer, Uri Ben-David, Daniele Fachinetti, Ylli Doksani, Stefano Santaguida
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
Externí odkaz:
https://doaj.org/article/e226f0a659b0484e8d7815070b875a08
Autor:
Riccardo Gamba, Giulia Mazzucco, Therese Wilhelm, Leonid Velikovsky, Catalina Salinas-Luypaert, Florian Chardon, Julien Picotto, Mylène Bohec, Sylvain Baulande, Ylli Doksani, Daniele Fachinetti
Publikováno v:
PLoS Genetics, Vol 18, Iss 7 (2022)
Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-stretches of tandem repetitive arrays. Despite being quite abundant compared to other loci, centromere sequences overall still represent only 2 to 5% o
Externí odkaz:
https://doaj.org/article/272faa3ba4e54c9fb8d4d6d44646dd6b
Autor:
Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini, Michele Giannattasio, Fabio Pessina, Ylli Doksani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermedia
Externí odkaz:
https://doaj.org/article/4794b362fc0f49848c87e429d2bef503
Autor:
Ylli Doksani, Titia de Lange
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1646-1656 (2016)
Shelterin protects chromosome ends from the DNA damage response. Although the mechanism of telomere protection has been studied extensively, the fate of double-strand breaks (DSBs) inside telomeres is not known. Here, we report that telomere-internal
Externí odkaz:
https://doaj.org/article/844f2f24122741e2a43b89e3c0215c7e
Autor:
Armela Huda, Hiroshi Arakawa, Giulia Mazzucco, Martina Galli, Valentina Petrocelli, Stefano Casola, Lu Chen, Ylli Doksani
Publikováno v:
Science Advances. 9
The telomerase reverse transcriptase elongates telomeres to prevent replicative senescence. This process requires exposure of the 3′-end, which is thought to occur when two sister telomeres are generated at replication completion. Using two-dimensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4479ea463539b94514a636d9b40315
https://doi.org/10.1126/sciadv.adf2011
https://doi.org/10.1126/sciadv.adf2011
Homologous recombination factors play a crucial role in protecting nascent DNA during replication but the role of chromatin in this process is largely unknown. Here, we used the bacterial Tus/Ter barrier known to induce a site-specific replication fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e11bc542bb9eedc4de392f62efd411
https://doi.org/10.21203/rs.3.rs-2301746/v1
https://doi.org/10.21203/rs.3.rs-2301746/v1
Autor:
Riccardo Gamba, Giulia Mazzucco, Therese Wilhelm, Leonid Velikovsky, Catalina Salinas-Luypaert, Florian Chardon, Julien Picotto, Mylène Bohec, Sylvain Baulande, Ylli Doksani, Daniele Fachinetti
Publikováno v:
PLoS genetics. 18(7)
Centromeres are key elements for chromosome segregation. Canonical centromeres are built over long-stretches of tandem repetitive arrays. Despite being quite abundant compared to other loci, centromere sequences overall still represent only 2 to 5% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0901101b313b648c122b8224243b36
https://pubmed.ncbi.nlm.nih.gov/35853083
https://pubmed.ncbi.nlm.nih.gov/35853083
Publikováno v:
Nature protocols. 17(6)
Here we provide a detailed protocol for the enrichment of telomeric repeats from mouse and human cells. The procedure consists of two successive rounds of digestion with frequently cutting restriction enzymes followed by size fractionation. Around 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea44396463b3dd1db1bd0b5e8ff2972f
https://pubmed.ncbi.nlm.nih.gov/35396546
https://pubmed.ncbi.nlm.nih.gov/35396546