Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02

Autor: Leire Iralde-Lorente, Ylenia Cau, Letizia Clementi, Lorenzo Franci, Giusy Tassone, Daniela Valensin, Mattia Mori, Adriano Angelucci, Mario Chiariello, Maurizio Botta

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 657-664 (2019)

14-3-3 are regulatory proteins that through protein–protein interactions (PPI) with numerous binding partners could be involved in several human diseases, including cancer, neurodegenerative disorders, and pathogens infections. Following our resear

Externí odkaz: https://doaj.org/article/0387ca67151143d8bee11b1f00a12246

Small Molecules as Potential Inhibitors of the 14-3-3/c-Abl Interaction for the Treatment of CML

Autor: Leire Iralde-Lorente, Giusy Tassone, Ylenia Cau, Claire Munier, Lorenzo Franci, Cecilia Pozzi, Adriano Angelucci, Mario Chiariello, Matthew Perry, Stefano Mangani, Maurizio Botta

Publikováno v: Proceedings, Vol 22, Iss 1, p 17 (2019)

c-Abl is a tyrosine kinase implicated in the regulation of proliferation, adhesion, motility, andcell survival [...]

Externí odkaz: https://doaj.org/article/bae4c4cff99d45deba1ba399c8422f85

Repurposing drugs for the management of COVID-19

Autor: Anna Maria Calvani, Jacopo Cusinato, Mattia Mori, Ylenia Cau

Publikováno v: Expert Opinion on Therapeutic Patents

Introduction : The coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 represents a serious health issue worldwide, with more than 61 million cases and more than 1.4 million death since the beginning of the epidemic near the end of 2019. The sci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0674e9f9080c44aef0bb3bd2e82678c6
https://pubmed.ncbi.nlm.nih.gov/33283567

Modulators of 14-3-3 protein-protein interactions

Autor: Ylenia Cau, Loes M. Stevers, Jeremy Martin Davis, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Andrew J. Wilson, Christian Ottmann, Isabelle Landrieu, Jan Eickhoff, Richard G. Doveston, Luc Brunsveld, GGavin O'Mahony, Tomas Obsil, Anna Karawajczyk, Michael M. Hann

Publikováno v: Journal of Medicinal Chemistry, 61(9), 3755-3778. American Chemical Society
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, 2017, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩
Journal of Medicinal Chemistry, American Chemical Society, 2017, 61 (9), pp.3755-3778. ⟨10.1021/acs.jmedchem.7b00574⟩

International audience; Direct interactions between proteins are essential for the regulation of their functions in biological pathways. Targeting the complex network of protein–protein interactions (PPIs) has now been widely recognized as an attra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae0a5b472d67707d90db7bf32f71729
https://doi.org/10.1021/acs.jmedchem.7b00574

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

Autor: Mattia Mori, Claudiu T. Supuran, Ylenia Cau, Maurizio Botta

Publikováno v: Organic & Biomolecular Chemistry. 14:8322-8330

A series of phenolic acids and some of their esters, derivatives of caffeic, ferulic, and p-coumaric acid, was investigated for the inhibition of three β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Mycobacterium tuberculosis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5d2a627e1a552769c2fdfc416081cb
https://doi.org/10.1039/c6ob01477a