Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity

Autor: Wenqing Mou, Yinglu Tang, Yunpeng Huang, Zhihao Wu, Yixian Cui

Publikováno v: Cell Reports, Vol 43, Iss 5, Pp 114255- (2024)

Summary: ER-phagy, a selective autophagy targeting the endoplasmic reticulum (ER) for lysosomal degradation through cargo receptors, plays a critical role in ER quality control and is linked to various diseases. However, its physiological and patholo

Externí odkaz: https://doaj.org/article/ce5b64c2737f42df9e9ff69b11992b02

Advances in ER-Phagy and Its Diseases Relevance

Autor: Yixian Cui, Xuehong Qian, Lingang He

Publikováno v: Cells, Vol 10, Iss 2328, p 2328 (2021)
Cells

As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis. The relationshi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b3411969086b8d1bfb35aa6db4f522
https://www.mdpi.com/2073-4409/10/9/2328

Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy

Autor: Yixian Cui, Muriel Mari, Smriti Parashar, Susan Ferro-Novick, Dongmei Liu, Fulvio Reggiori, Peter Novick, Shuliang Chen

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 31
Proceedings of the National Academy of Sciences of the United States of America, 117(31), 18530-18539. NATL ACAD SCIENCES
Proc Natl Acad Sci U S A

Endoplasmic reticulum (ER) macroautophagy (hereafter called ER-phagy) uses autophagy receptors to selectively degrade ER domains in response to starvation or the accumulation of aggregation-prone proteins. Autophagy receptors package the ER into auto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02197d3863f584e720adcb2bfa20dfd2
https://escholarship.org/uc/item/5k59g029

A novel Drosophila mitochondrial carrier protein acts as a Mg 2+ exporter in fine-tuning mitochondrial Mg 2+ homeostasis

Autor: Shanke Zhao, Bing Zhou, Yixian Cui, Xudong Wang

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863(1):30-39

The homeostasis of magnesium (Mg(2+)), an abundant divalent cation indispensable for many biological processes including mitochondrial functions, is underexplored. In yeast, the mitochondrial Mg(2+) homeostasis is accurately controlled through the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e05b92755e8ff305c12fb80fd77422

Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy.

Autor: Shuliang Chen, Mari, Muriel, Parashar, Smriti, Dongmei Liu, Yixian Cui, Reggiori, Fulvio, Novick, Peter J., Ferro-Novick, Susan

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 8/4/2020, Vol. 117 Issue 31, p18530-18539, 10p