Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Yiwen Bu"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The transcription factor CHOP/GADD153 regulates apoptosis in response to the unfolded protein response. Here the authors show that CHOP/GADD153 regulates the expression of miR-216b, which targets c-Jun and sensitizes cells to ER stress-dependent apop
Externí odkaz:
https://doaj.org/article/6d137a4778be455fb9413524429c2495
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Purpose: Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase 1B10 (AKR1B10) is specifically expressed in the colonic epithelium, but downregulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7aa35704aa330e5e813dbe5e4ddae1
https://doi.org/10.1158/1078-0432.c.6523917
https://doi.org/10.1158/1078-0432.c.6523917
Autor:
Deliang Cao, Duan-Fang Liao, William F. Stenson, Mei Chris Huang, Jianghua Liu, Xuyu Zu, Laxiang Wan, Yingchun He, Yu Cao, Yiwen Bu, Chenfei Huang, John Gao, Wancai Yang, Xiaoning Li, Hongyan Ling, Ruilan Yan, Jun Ma, Yi Shen
Supplemental Figures S1-6, Tables S1-7. Figure S1. Targeted disruption of AKR1B8 gene. Figure S2. AKR1B and AKR1C subfamily expression. Figure S3. Deficiency of proliferation and self-renewal of colonic crypt cells in AKR1B8 -/- mice. Figure S4. DSS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac58dd7208294b177c0224ed74e2203
https://doi.org/10.1158/1078-0432.22458351.v1
https://doi.org/10.1158/1078-0432.22458351.v1
Autor:
Min Gyu Lee, Yiwen Bu, Dongyu Zhao, Kaifu Chen, Man Zhou, Guangyu Wang, Yanqiang Li, Xin Wang, Lili Zhang, Qi Cao, John P. Cooke, Bo Xia, Jie Lv
Publikováno v:
Genomics, Proteomics & Bioinformatics
Numerous studies of relationship between epigenomic features have focused on their strong correlation across the genome, likely because such relationship can be easily identified by many established methods for correlation analysis. However, two feat
Autor:
Yiwen Bu, Kaifu Chen, John P. Cooke, Jie Lv, Min Gyu Lee, Yanqiang Li, Qi Cao, Xin Wang, Dongyu Zhao, Lili Zhang, Bo Xia, Guangyu Wang, Man Zhou
Numerous studies of relationship between epigenomic features have focused on their strong correlation across the genome, likely because such relationship can be easily identified by many established methods for correlation analysis. However, two feat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6daa115114d412b8ec2d658713796a03
https://doi.org/10.1101/2020.08.12.247361
https://doi.org/10.1101/2020.08.12.247361
Autor:
Junfei Jin, Dan Huang, Deliang Cao, Duan-Fang Liao, Chenfei Huang, Guiyuan Shi, Haitao Ji, Yi Shen, Yiwen Bu, Jun Ma, Zhe Cao, Ramina Khoshaba
Publikováno v:
Molecular Carcinogenesis. 57:1300-1310
Aldo-keto reductase 1B10 (AKR1B10) is upregulated in breast cancer and promotes tumor growth and metastasis. However, little is known of the molecular mechanisms of action. Herein we report that AKR1B10 activates lipid second messengers to stimulate
Autor:
Akihiro Yoshida, E. Ramsay Camp, Karen E. Knudsen, John Wrangle, Shuo Qie, Renée de Leeuw, J. Alan Diehl, Yiwen Bu, E. Starr Hazard, Gary Hardiman
Publikováno v:
Yoshida, A, Bu, Y, Qie, S, Wrangle, J, Camp, E R, Hazard, E S, Hardiman, G, de Leeuw, R, Knudsen, K E & Diehl, J A 2019, ' SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors ', Science Advances, vol. 5, no. 9, eaax6352 . https://doi.org/10.1126/sciadv.aax6352
Science Advances
Science Advances
We identified unique molecular mechanisms of resistance to CDK4/6 inhibitors, an area of intense biomedical investigation.
The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic ta
The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic ta
Autor:
Nilesh Chitnis, Kent Armeson, Constantinos Koumenis, Gerald Wertheim, Yiwen Bu, J. Alan Diehl, Akihiro Yoshida, Chi V. Dang, Amanda R. Oran, Feven Tameire, Davide Ruggero, Serge Y. Fuchs, Victoria J. Gennaro, Brian J. Altman, Steven B. McMahon
Publikováno v:
Nature Cell Biology. 20:104-115
The unfolded protein response (UPR) is a stress-activated signalling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We explore how UPR sig
Autor:
Kenneth A. Snyder, Robert Spragg, Dale P. Bentz, Yiwen Bu, Yang Lu, Scott Z. Jones, Jason Weiss
Publikováno v:
Cement and Concrete Composites. 79:94-105
Electrical tests have been used to characterize the microstructure of porous materials, the measured electrical response being determined by the contribution of the microstructure (porosity and tortuosity) and the electrical properties of the solutio
Autor:
Chun Cai, Chenfei Huang, Yuhong Wang, Dan Huang, Yi Shen, Krishna Rao, Duan-Fang Liao, Junfei Jin, Yiwen Bu, Steven J. Verhulst, Yu Cao, Yingchun He, Deliang Cao
Publikováno v:
Oncotarget
Aldo-keto reductase 1B10 (AKR1B10) is not expressed in normal breast, but upregulated in primary and metastatic breast cancers, being a negative prognostic factor. This study characterized the molecular mechanisms of AKR1B10-promoted breast cancer me