Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yiu-Yin Cheung"'
Autor:
Adam J. Rosenberg, Yiu-Yin Cheung, Fei Liu, Carina Sollert, Todd E. Peterson, Jonathan A. Kropski
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Background Radiopharmaceuticals capable of targeting the fibroblast activation protein have become widely utilized in the research realm as well as show great promise to be commercialized; with [68Ga]Ga-FAPI-46 being one of the most widely u
Externí odkaz:
https://doaj.org/article/a89be5f949a74202b6834c4ed739c8ca
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 90KB, Scheme 1. 19FFB-VAD-FMK (3) (A) and 127IIZ-VAD-FMK (5) (B) synthetic schemes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888ba9dc16f20baa6ca82445a33c310a
https://doi.org/10.1158/1078-0432.22447991
https://doi.org/10.1158/1078-0432.22447991
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
Purpose: Apoptosis, or programmed cell death, can be leveraged as a surrogate measure of response to therapeutic interventions in medicine. Cysteine aspartic acid–specific proteases, or caspases, are essential determinants of apoptosis signaling ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0fbe78ef763d965cf39ffd36bb1228
https://doi.org/10.1158/1078-0432.c.6521267.v1
https://doi.org/10.1158/1078-0432.c.6521267.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 79KB, 19FFB-VAD-FMK and parent peptide enzyme selectivity. Biochemistry, fluorescence measured IC50 values, collected as duplicates, of the parent peptide, VAD-FMK, and 19FFB-VAD-FMK against caspases-3/6/7/8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0557abef2d4bdfa3dcf3d12cadc7b43a
https://doi.org/10.1158/1078-0432.22447994
https://doi.org/10.1158/1078-0432.22447994
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 165KB, Supplemental Materials and Methods, Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b3efe4bbbe341fd729ace9ce340ff2
https://doi.org/10.1158/1078-0432.22447982.v1
https://doi.org/10.1158/1078-0432.22447982.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 137KB, IHC semi-quantification. Semi-quantitative analysis of cleaved caspase-3 histological samples of DLD-1 and SW620 xenograft tumors treated with vehicle or AZD-1152 (A). Evaluation of multiple low field (2.5x) micrographs revealed a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ea45e9e55938c4ee72be9a67033bec
https://doi.org/10.1158/1078-0432.22447985
https://doi.org/10.1158/1078-0432.22447985
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 93KB, Scheme 2. 18FSFB (9) (A) and 18FFB-VAD-FMK (11) (B) synthetic schemes. Compound (9) radiosynthesis was performed systematically using an automated radiochemistry module.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239836094c3fb17d7e7b7d00c483b3be
https://doi.org/10.1158/1078-0432.22447988.v1
https://doi.org/10.1158/1078-0432.22447988.v1
Autor:
H. Charles Manning, Robert J. Coffey, M. Kay Washington, Dewei Tang, Jason R. Buck, Samir Saleh, Ping Zhao, Eric S. Dawson, Michael L. Nickels, Yiu-Yin Cheung, Matthew R. Hight
PDF file - 43KB, Docking scores are reported as ranked by the Crash (steric repulsion) score from the protein flexibility (PF-score) scoring function of the Tripos SYBYL-X v2.0 software suite that also features (among other scoring parameters) compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d1703fb7d31ab46f15c792fb611703
https://doi.org/10.1158/1078-0432.22447979
https://doi.org/10.1158/1078-0432.22447979
Autor:
Adam J. Rosenberg, Yiu‐Yin Cheung, Fei Liu, Todd E. Peterson, James Silverman, Ciaran M. Considine, Daniel O. Claassen
Publikováno v:
J Labelled Comp Radiopharm
(R)-[(18)F]MH.MZ ([(18)F]MH.MZ) is a promising positron emission tomography (PET) radiotracer for in vivo study of the 5-HT(2A) receptor. To facilitate clinical trials a fully automated radiosynthesis procedure for [(18)F]MH.MZ was developed using co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52aaf7733a13317653769004f07c086
https://doi.org/10.1002/jlcr.3975
https://doi.org/10.1002/jlcr.3975
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4466-4471
A novel synthesis of the translocator protein (TSPO) ligand 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575, 3) was achieved in four steps from commercially available starting materials. Focused s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efdd1750ee3534839be64b6c19ef0527
https://doi.org/10.1016/j.bmcl.2014.07.091
https://doi.org/10.1016/j.bmcl.2014.07.091