Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Yisheng, Lai"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 291 (2024)
Background: Breast cancer is a commonly diagnosed cancer worldwide. Human MutT homolog 1 (MTH1) is found to be elevated in breast tumors and cancer cells need MTH1 for survival. Pharmacological inhibition of MTH1 may be potentially beneficial in the
Externí odkaz:
https://doaj.org/article/9ec6e81e1a5347bcbd4a646003f788f8
Autor:
Shushan Ge, Haiqing Zhong, Xuewei Ma, Yingbo Zheng, Yi Zou, Fang Wang, Yan Wang, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo, Qiang Xu, Yisheng Lai
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1240-1257 (2020)
Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the
Externí odkaz:
https://doaj.org/article/999492738840416e803d20a2a0c7249a
Autor:
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo
Publikováno v:
The Journal of Immunology. 209:180-191
The pharmacological inhibition of IDO1 is considered an effective therapeutic approach for cancer treatment. However, the inadequate response of existing holo-IDO1 inhibitors and unclear biomarkers available in clinical practice limit the possibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c857d7f50292a5017cab3c94747c350
https://doi.org/10.4049/jimmunol.2100938
https://doi.org/10.4049/jimmunol.2100938
Autor:
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo
Publikováno v:
The Journal of Immunology.
Liu, W., Y. Zou, K. Li, H. Zhong, L. Yu, S. Ge, Y. Lai, X. Dong, Q. Xu, and W. Guo. 2022. Apo-form selective inhibition of IDO for tumor immunotherapy. J. Immunol. 209: 180–191. Supplemental Table I did not originally contain the Protein Data Bank
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1313efacc1dc40d5c6f4b4ba07264359
https://doi.org/10.4049/jimmunol.2300257
https://doi.org/10.4049/jimmunol.2300257
Autor:
Rongjie, Cheng, Xiashi, Lv, Huagang, Bu, Qiaoliang, Xu, Jianzhuang, Wu, Kexin, Xie, Jiaqi, Tang, Lei, Wang, Jian, Zhuang, Yihua, Zhang, Yaliang, Zhang, Chao, Yan, Yisheng, Lai
Publikováno v:
European journal of medicinal chemistry. 244
KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11d19cd3b710e0ab8364b4557b661a1e
https://pubmed.ncbi.nlm.nih.gov/36228411
https://pubmed.ncbi.nlm.nih.gov/36228411
Autor:
Jian Gao, Lu Yue, Jin Shuanglong, Wenjie Guo, Hua Tang, Lei Zhao, Li Yuezhen, Qiang Xu, Ouyang Yiqiang, Haiqing Zhong, Yisheng Lai, Junfeng Lu
Publikováno v:
Journal of Medicinal Chemistry. 64:7646-7666
Two series of novel o-(biphenyl-3-ylmethoxy)nitrophenyl compounds (A1-31 and B1-17) were designed as programmed cell death protein 1 (PD-1)/PD-ligand 1 (PD-L1) inhibitors. All compounds showed significant inhibitory activity with IC50 values ranging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f7211d6b404e9a3ca9cef7b95c5a04
https://doi.org/10.1021/acs.jmedchem.1c00370
https://doi.org/10.1021/acs.jmedchem.1c00370
Autor:
Longbo Yu, Yuanyuan Wang, Yingxue He, Haiqing Zhong, Shushan Ge, Yi Zou, Yisheng Lai, Qiang Xu, Jian Gao, Wen Liu, Wenjie Guo
Publikováno v:
International immunopharmacology. 112
Colorectal cancer (CRC) is the third most common cancer in the world. Recently, many clinical studies have demonstrated the therapeutic potential of immune checkpoint therapy combined with inhibitors of vascular endothelial growth factor receptor 2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d7c2b8e2d9dcfdec25327f0720cec1
https://pubmed.ncbi.nlm.nih.gov/36126409
https://pubmed.ncbi.nlm.nih.gov/36126409
Autor:
Haiqing Zhong, Yue Hu, Yi Zou, Wang Fang, Yisheng Lai, Yan Wang, Li Yuezhen, Wenjie Guo, Ge Shushan, Qiang Xu, Zheng Yingbo, Wen Liu, Xuewei Ma
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1240-1257 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1240-1257 (2020)
Indoleamine 2,3-dioxygenase 1 (IDO1) as a key rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism plays an important role in tumour immune escape. Herein, a variety of secondary sulphonamides were synthesised and evaluated in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cbfdc5ca8196d2396f0bf3ee09ccc8
http://europepmc.org/articles/PMC7336998
http://europepmc.org/articles/PMC7336998
Publikováno v:
International Journal of Mathematics and Mathematical Sciences, Vol 2005, Iss 12, Pp 1879-1887 (2005)
By using fixed point index approach for multivalued mappings, the existence of nonzero solutions for a class of generalized variational inequalities is studied in reflexive Banach space. One of the mappings concerned here is coercive or monotone and
Externí odkaz:
https://doaj.org/article/19413b6bb90b4d848fda6c42d87b4cea
Publikováno v:
Computer Aided Geometric Design. 70:1-15
It was proven by Cox, Goldman and Zhang that a tensor product rational surface without base points can be implicitized by moving quadrics whenever the rational surface doesn't contain low degree moving planes following it. However, when the rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd494b5282a06f7d4c02250aa9cee38
https://doi.org/10.1016/j.cagd.2019.03.001
https://doi.org/10.1016/j.cagd.2019.03.001