Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Yiru Jin"'
Autor:
Yiru Jin, Somrita Basu, Mei Feng, Yu Ning, Indeewara Munasinghe, Arline M. Joachim, Junan Li, Lingli Qin, Robert Madden, Hannah Burks, Philip Gao, Judy Qiju Wu, Salma Waheed Sheikh, April C. Joice, Chamani Perera, Karl A. Werbovetz, Kai Zhang, Michael Zhuo Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Visceral leishmaniasis is a life-threatening parasitic disease, but current antileishmanial drugs have severe drawbacks. Antifungal azoles inhibit the activity of cytochrome P450 (CYP) 51 enzymes which are responsible for removing the C14α-
Externí odkaz:
https://doaj.org/article/a3ce727063f642c094c61d131e68336b
Autor:
Mei Feng, Yiru Jin, Sihyung Yang, Arline M. Joachim, Yu Ning, Luis M. Mori-Quiroz, Jacob Fromm, Chamani Perera, Kai Zhang, Karl A. Werbovetz, Michael Zhuo Wang
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 20, Iss , Pp 27-42 (2022)
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations. The ergosterol biosynthetic pathway has been identified as a drug target
Externí odkaz:
https://doaj.org/article/ea724cff641344e69fa0fd6c243fb795
Autor:
Angel M. Padilla, Wei Wang, Tsutomu Akama, David S. Carter, Eric Easom, Yvonne Freund, Jason S. Halladay, Yang Liu, Sarah A. Hamer, Carolyn L. Hodo, Gregory K. Wilkerson, Dylan Orr, Brooke White, Arlene George, Huifeng Shen, Yiru Jin, Michael Zhuo Wang, Susanna Tse, Robert T. Jacobs, Rick L. Tarleton
Publikováno v:
Nature microbiology. 7(10)
Trypanosoma cruzi, the agent of Chagas disease, probably infects tens of millions of people, primarily in Latin America, causing morbidity and mortality. The options for treatment and prevention of Chagas disease are limited and underutilized. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a107b3816471fc4544d97ceaccbbe5e
https://pubmed.ncbi.nlm.nih.gov/36195774
https://pubmed.ncbi.nlm.nih.gov/36195774
Autor:
April C. Joice, Xiaoping Liao, Emilia M. Zywot, Craig A. McElroy, Karl A. Werbovetz, Heidi L. Meeds, Michael Zhuo Wang, Mei Feng, Junan Li, Ahmed Abdelhameed, Yena Kim, Yiru Jin, Chris La Rosa
Publikováno v:
ACS Infect Dis
Due to the limitations of existing medications, there is a critical need for new drugs to treat visceral leishmaniasis. Since arylimidamides and antifungal azoles both show oral activity in murine visceral leishmaniasis models, a molecular hybridizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1df53774e2a90941b8ba5079b68024
https://pubmed.ncbi.nlm.nih.gov/33538576
https://pubmed.ncbi.nlm.nih.gov/33538576
Prenatal diagnosis of trisomy 21, 18 and 13 by quantitative pyrosequencing of segmental duplications
Autor:
Bingjie Zou, Huan Tong, Qinxin Song, Yinqiu Xu, Janet L. Pitman, Hui Ye, Guohua Zhou, Haiping Wu, Shalen Kumar, Yiru Jin
Publikováno v:
Clinical Genetics. 90:451-455
Chromosomal aberration mostly occurs in chromosomes 21, 18 and 13, with an incidence approximately 1 out of 160 live births in humans, therefore making prenatal diagnosis necessary in clinics. Current methods have drawbacks such as time consuming, hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29eea1ca1b6b631bd18ea5fcd8d068c
https://doi.org/10.1111/cge.12772
https://doi.org/10.1111/cge.12772
Publikováno v:
Springer Protocols Handbooks ISBN: 9781493933068
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ebd87551a7f239f4a12723c72c74d4
https://doi.org/10.1007/978-1-4939-3308-2_13
https://doi.org/10.1007/978-1-4939-3308-2_13
