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Akademický článek

Increased blood-based intratumor heterogeneity (bITH) is associated with unfavorable outcomes of immune checkpoint inhibitors plus chemotherapy in non-small cell lung cancer

Autor: Juan Zhou, Minwei Bao, Guanghui Gao, Yiran Cai, Lihong Wu, Lei Lei, Jing Zhao, Xianxiu Ji, Ying Huang, Chunxia Su

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)

Abstract Background The combination of immune checkpoint inhibitors (ICIs) and chemotherapy has been the standard first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with driver-gene negative. However, efficacy biomarkers fo

Externí odkaz: https://doaj.org/article/79013bb61c8b4eb9a2592324c731442f

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Akademický článek

bITH, a blood-based metric of intratumor heterogeneity, is associated with clinical response to immune checkpoint blockade in non-small cell lung cancerResearch in context

Autor: Yun Fan, Yang Liu, Liuchun Wang, Yiran Cai, Wen Cao, Wenjie Sun, Xiao Zou, Bing Li, Zhou Zhang, Shangli Cai, Shannon Chuai, Yusheng Han, Xiaojie Pan, Dingzhi Huang

Publikováno v: EBioMedicine, Vol 91, Iss , Pp 104564- (2023)

Summary: Background: Intratumor heterogeneity (ITH) has been associated with poor prognosis in advanced non-small cell cancer (NSCLC) patients receiving immune checkpoint blockade (ICB) therapies. However, there is currently no evidence supporting an

Externí odkaz: https://doaj.org/article/21839e0e55fc42e284442ac22f1bea05

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Akademický článek

Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression

Autor: Yiran Cai, Hongbo Wu, Xiaoqin Shi, Yujie Dong, Xiujun Chang, Li Zhang, Lijuan Zhou, Dan Su, Ming Yang

Publikováno v: BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)

Abstract Background Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, it remains confused t

Externí odkaz: https://doaj.org/article/0a54f4b6d8424865b6207a106675109b

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Akademický článek

Clinical characteristics and outcomes of patients with primary lung adenocarcinoma harboring ALK rearrangements detected by FISH, IHC, and RT-PCR.

Autor: Jinghui Wang, Yiran Cai, Yujie Dong, Jingying Nong, Lijuan Zhou, Guimei Liu, Dan Su, Xi Li, Shafei Wu, Xuejing Chen, Na Qin, Xuan Zeng, Haiqing Zhang, Zongde Zhang, Shucai Zhang

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e101551 (2014)

EML4-ALK is a new driver gene of non-small cell lung cancer and a target of crizotinib. The objectives of this study were to determine the frequency of ALK rearrangements in a large cohort of patients with primary lung adenocarcinoma and to analyze t

Externí odkaz: https://doaj.org/article/128b288cbaac4dcd933f71f19516abaf

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