Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Yiping Fan"'
Autor:
Teja Celhar, Xinyi Li, Yunqian Zhao, Hui Chien Tay, Andrea Lee, Hui Hua Liew, Edwin Kunxiang Shepherdson, Ravisankar Rajarethinam, Yiping Fan, Anselm Mak, Jerry Kok Yen Chan, Amit Singhal, Takeshi Takahashi
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Transplantation of CD34+ hematopoietic stem and progenitor cells (HSPC) into immunodeficient mice is an established method to generate humanized mice harbouring a human immune system. Different sources and methods for CD34+ isolat
Externí odkaz:
https://doaj.org/article/44fa92d27ecf4fc9a705870d4e0effd3
Autor:
Timothy I. Shaw, Jessica Wagner, Liqing Tian, Elizabeth Wickman, Suresh Poudel, Jian Wang, Robin Paul, Selene C. Koo, Meifen Lu, Heather Sheppard, Yiping Fan, Francis H. O’Neill, Ching C. Lau, Xin Zhou, Jinghui Zhang, Stephen Gottschalk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Immunotherapy with chimeric antigen receptor T cells for pediatric solid and brain tumors is constrained by available targetable antigens. Cancer-specific exons present a promising reservoir of targets; however, these have not been explored
Externí odkaz:
https://doaj.org/article/a7f623660f4c451a9230c9fee62ee7a1
Autor:
Fuyao Yu, Chuan Xing, Yiping Fan, Yanping Liu, Peng Su, Qiuhua Yang, Yanbin Dong, Yang Hou, Shinong Pan
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Physical exercise is the first-line intervention for prediabetes, and metformin is the most widely used oral insulin-sensitizing agent. Moreover, intermuscular adipose tissue (IMAT) directly affects insulin resistance by helping m
Externí odkaz:
https://doaj.org/article/2ad1b296f7964e898f099cd3f60dfe00
Autor:
Yurika Matsui, Mohamed Nadhir Djekidel, Katherine Lindsay, Parimal Samir, Nina Connolly, Gang Wu, Xiaoyang Yang, Yiping Fan, Beisi Xu, Jamy C. Peng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Stem cell survival versus death is a developmentally programmed process essential for morphogenesis, sizing, and quality control of genome integrity and cell fates. Cell death is pervasive during development, but its programming is little kn
Externí odkaz:
https://doaj.org/article/61d9ca38368f449c94fe27afcd198755
Autor:
Jie Fang, Shivendra Singh, Changde Cheng, Sivaraman Natarajan, Heather Sheppard, Ahmed Abu-Zaid, Adam D. Durbin, Ha Won Lee, Qiong Wu, Jacob Steele, Jon P. Connelly, Hongjian Jin, Wenan Chen, Yiping Fan, Shondra M. Pruett-Miller, Jerold E. Rehg, Selene C. Koo, Teresa Santiago, Joseph Emmons, Stefano Cairo, Ruoning Wang, Evan S. Glazer, Andrew J. Murphy, Taosheng Chen, Andrew M. Davidoff, Carolina Armengol, John Easton, Xiang Chen, Jun Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this neoplasm. Here, we report an improved MYC-driven hepatoblastoma-like murine model that re
Externí odkaz:
https://doaj.org/article/518df2bf603d4dbaa5922a65b63e4a51
Autor:
Jennifer L. Kamens, Stephanie Nance, Cary Koss, Beisi Xu, Anitria Cotton, Jeannie W. Lam, Elizabeth A. R. Garfinkle, Pratima Nallagatla, Amelia M. R. Smith, Sharnise Mitchell, Jing Ma, Duane Currier, William C. Wright, Kanisha Kavdia, Vishwajeeth R. Pagala, Wonil Kim, LaShanale M. Wallace, Ji-Hoon Cho, Yiping Fan, Aman Seth, Nathaniel Twarog, John K. Choi, Esther A. Obeng, Mark E. Hatley, Monika L. Metzger, Hiroto Inaba, Sima Jeha, Jeffrey E. Rubnitz, Junmin Peng, Taosheng Chen, Anang A. Shelat, R. Kiplin Guy, Tanja A. Gruber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
KMT2A rearranged infant acute lymphoblastic leukemia patients have a poor prognosis. Here, the authors use high throughput drug screening on primary infant specimens to identify a clinically active chemotherapy combination.
Externí odkaz:
https://doaj.org/article/2cd886b587c94bdaa2bd04fdff849913
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Improvements in reproductive techniques have resulted in the live birth rates from IVF procedures increasing from 5% to approximately 30% in recent decades but has plateaued since. Emerging preclinical and clinical data implicates endometria
Externí odkaz:
https://doaj.org/article/b5328e0d979b4b3b829d3c0863a59977
Autor:
Guillem Sanchez Sanchez, Maria Papadopoulou, Abdulkader Azouz, Yohannes Tafesse, Archita Mishra, Jerry K. Y. Chan, Yiping Fan, Isoline Verdebout, Silvana Porco, Frédérick Libert, Florent Ginhoux, Bart Vandekerckhove, Stanislas Goriely, David Vermijlen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Knowledge about the ontogeny of T cells in the thymus relies heavily on mouse studies because of difficulty to obtain human material. Here the authors perform a single cell analysis of thymocytes from human fetal and paediatric thymic samples to char
Externí odkaz:
https://doaj.org/article/6dfe7ee0d486441f82161526cf2ca7ec
Autor:
Flavia A. Graca, Mamta Rai, Liam C. Hunt, Anna Stephan, Yong-Dong Wang, Brittney Gordon, Ruishan Wang, Giovanni Quarato, Beisi Xu, Yiping Fan, Myriam Labelle, Fabio Demontis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Myofiber atrophy occurs in many diseases but the mechanisms responsible for myofiber size determination are incompletely understood. Here, the authors show that the muscle-secreted factor Fibcd1 is necessary to maintain myofiber size and mitigates my
Externí odkaz:
https://doaj.org/article/5cbdb4d779ef41379fe96cd79ef579e7
Autor:
Jianqin Jiao, Michelle Curley, Flavia A. Graca, Maricela Robles-Murguia, Abbas Shirinifard, David Finkelstein, Beisi Xu, Yiping Fan, Fabio Demontis
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111970- (2023)
Summary: Protein quality control is important for healthy aging and is dysregulated in age-related diseases. The autophagy-lysosome and ubiquitin-proteasome are key for proteostasis, but it remains largely unknown whether other proteolytic systems al
Externí odkaz:
https://doaj.org/article/bde9aaea4839427f897ff30d5ece83b5