Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yip, Yvonne"'
Autor:
Gregory P. Donoho, Philip Parker Waid, James A. Cook, Michele C. Smith, David Anthony Barda, Volker Wacheck, Yip Yvonne Yee Mai, Philip W. Iversen, Rose T. Ajamie, Debra A. Young, Mary M. Mader, Douglas J. Zeckner, Manuel Vincente Sanchez-Felix, Everett J. Perkins, Laura J. Bloem
Publikováno v:
Molecular Cancer Therapeutics. 15:2344-2356
The PI3K/AKT/mTOR pathway is among the most frequently altered pathways in cancer cell growth and survival. LY3023414 is a complex fused imidazoquinolinone with high solubility across a wide pH range designed to inhibit class I PI3K isoforms and mTOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80159e5e71a960fd869a5fce50b85364
https://doi.org/10.1158/1535-7163.mct-15-0996
https://doi.org/10.1158/1535-7163.mct-15-0996
Autor:
John E. Munroe, Q. May Wang, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Robert B. Johnson, Guo Deqi, Beverly A. Heinz, Jason Eric Lamar, Joseph M. Colacino, John I. Glass, Yip Yvonne Yee Mai
Publikováno v:
Letters in Drug Design & Discovery. 2:118-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26be57b77d8fdb1284a536e0ce97f6a2
https://doi.org/10.2174/1570180053175115
https://doi.org/10.2174/1570180053175115
Autor:
Q. May Wang, John I. Glass, Yip Yvonne Yee Mai, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, Nancy June Snyder, Guo Deqi, Jason Eric Lamar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:257-261
With the aim of discovering potent and selective HCV protease inhibitors, we synthesized and evaluated a series of 1a based tetrapeptidyl ketoamides with additional modification(s) at P1′, P1, and P3 positions. As a result of this effort, we found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f275bbea4f02e46d25f244e2fcf482cd
https://doi.org/10.1016/j.bmcl.2003.09.075
https://doi.org/10.1016/j.bmcl.2003.09.075
Autor:
Jason Eric Lamar, Ling Jin, Daryl Venable, Lifei Liu, Mark Joseph Tebbe, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Q. May Wang, Yip Yvonne Yee Mai, Donna Barket, Robert B. Johnson, Joe Colacino, Mark Wakulchik, John E. Munroe, Beverly A. Heinz, John I. Glass, Congping Xie, Elcira C. Villarreal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:251-256
We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03ae4d6ce258904c379bc3ebcafdec6
https://doi.org/10.1016/j.bmcl.2003.09.074
https://doi.org/10.1016/j.bmcl.2003.09.074
Akademický článek
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Autor:
Mark Wakulchik, Q. May Wang, Jason Eric Lamar, Frantz Victor, Shu-Hui Chen, Nathan Yumibe, Robert B. Johnson, John E. Munroe, Yip Yvonne Yee Mai, John I. Glass
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(19)
With the aim of improving HCV protease inhibitors reported in our previous manuscripts, we synthesized and evaluated a series of 1a-based tetrapeptidyl α-ketoamides with additional P4 modification. The promising analog discovered through this SAR, 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f6f1e707cb9d27bca6dfaafdef57be
https://pubmed.ncbi.nlm.nih.gov/15341970
https://pubmed.ncbi.nlm.nih.gov/15341970
Autor:
Shu-Hui Chen, David X Sun, Beverly A. Heinz, Yip Yvonne Yee Mai, Lifei Liu, Alexander A. Kolykhalov, Jason Eric Lamar, Q. May Wang, Robert B. Johnson
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
We describe herein the design, syntheses, and biological evaluation of new series of P4 tetrazole and adipic acid, ester, amide capped tetrapeptidyl alpha-ketoamide based HCV protease inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c26f66135fef5b6e9da403595e63aa9
https://pubmed.ncbi.nlm.nih.gov/15261297
https://pubmed.ncbi.nlm.nih.gov/15261297
Autor:
Jason Eric Lamar, Jon A. Erickson, Todd J. Kohn, Mccarthy James R, Hsiu-Chiung Yang, Guo Deqi, Patrick C. May, Shu-Hui Chen, David E. Timm, Yip Yvonne Yee Mai, James McGee
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(1)
With the aim of reducing molecular weight and adjusting log D value of BACE inhibitors to more favorable range for BBB penetration and better bioavailability, we synthesized and evaluated several series of P3 cap modified BACE inhibitors obtained via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef89648637cacd5fc94accf69e0348
https://pubmed.ncbi.nlm.nih.gov/14684336
https://pubmed.ncbi.nlm.nih.gov/14684336
Autor:
Chen, Shu-Hui, Lamar, Jason, Guo, Deqi, Kohn, Todd, Yang, Hsiu-Chiung, McGee, James, Timm, David, Erickson, Jon, Yip, Yvonne, May, Patrick, McCarthy, James
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2004 14(1):245-250
Autor:
Victor, Frantz, Lamar, Jason, Snyder, Nancy, Yip, Yvonne, Guo, Deqi, Yumibe, Nathan, Johnson, Robert B., Wang, Q.May, Glass, John I., Chen, Shu-Hui
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2004 14(1):257-261