Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yinyan Tang"'
Autor:
Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha, Miranda Sam, Qinshan Gao, Haihong Zhou, David U. Grandy, Sujata Singh, Zhiyun Wen, Christopher Warren, Xiaohong Shirley Ma, Daniel Malashock, Jennifer Galli, Gwenny Go, Michael Eddins, Todd Mayhood, Karthik Sathiyamoorthy, Arthur Fridman, Fahimeh Raoufi, Yacob Gomez-Llorente, Andrea Patridge, Yinyan Tang, Shi-Juan Chen, Marc Bailly, Chengjie Ji, Laura J. Kingsley, Alan C. Cheng, Bernhard H. Geierstanger, Daniel M. Gorman, Lan Zhang, Kalyan Pande
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19
Externí odkaz:
https://doaj.org/article/a9d7ab42a9cb4a6cb05bac47eef92301
Autor:
Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in
Externí odkaz:
https://doaj.org/article/8fad18ce72e441399290291663f48c2c
Autor:
Peter Kirk, Murali Addepalli, Thomas Chang, Palakshi Obalapur, Peiwen Kuo, Phi Quach, Jonathan Zalevsky, Rhoneil Pena, Saul Kivimae, Werner Rubas, Takahiro Miyazaki, Loui Madakamutil, Mekhala Maiti, Marlene Hennessy, Sara Sheibani, Joanna Wilczek, Janet Cetz, Andrew Moffett, Yinyan Tang, Jicai Huang, Dawei Sheng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 5 (2021)
Background NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differe
Externí odkaz:
https://doaj.org/article/e08faa8782fa46a5a98602da0126f298
Publikováno v:
Acta Cirúrgica Brasileira, Vol 36, Iss 2 (2021)
ABSTRACT Purpose The present study explored the influence of liraglutide on remote preconditioning-mediated cardioprotection in diabetes mellitus along with the role of nuclear factor erythroid 2-related factor 2 (Nrf2), hypoxia inducible factor (HIF
Externí odkaz:
https://doaj.org/article/5e1214843da44d7eaa5d9aa28b99ed14
Autor:
Neha Dixit, Christie Fanton, John L. Langowski, Yolanda Kirksey, Peter Kirk, Thomas Chang, Janet Cetz, Vidula Dixit, Grace Kim, Peiwen Kuo, Mekhala Maiti, Yinyan Tang, Laurie A. VanderVeen, Ping Zhang, Myong Lee, Jerome Ritz, Yusuke Kamihara, Chunmei Ji, Werner Rubas, Theresa D. Sweeney, Stephen K. Doberstein, Jonathan Zalevsky
Publikováno v:
Journal of Translational Autoimmunity, Vol 4, Iss , Pp 100103- (2021)
Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell stimulator,
Externí odkaz:
https://doaj.org/article/63812ff90adf4c7e9449ec1fa8aa92e5
Autor:
Christopher E Heise, Jeremy Murray, Katherine E Augustyn, Brandon Bravo, Preeti Chugha, Frederick Cohen, Anthony M Giannetti, Paul Gibbons, Rami N Hannoush, Brian R Hearn, Priyadarshini Jaishankar, Cuong Q Ly, Kinjalkumar Shah, Karen Stanger, Micah Steffek, Yinyan Tang, Xianrui Zhao, Joseph W Lewcock, Adam R Renslo, John Flygare, Michelle R Arkin
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50864 (2012)
Inhibition of caspase-6 is a potential therapeutic strategy for some neurodegenerative diseases, but it has been difficult to develop selective inhibitors against caspases. We report the discovery and characterization of a potent inhibitor of caspase
Externí odkaz:
https://doaj.org/article/86e58beea90d4df59b4e81e29a6f24b6
Autor:
Kurt S. Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter S. Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin K. Leung, Raymond A. Ng, Andrew J. Ambrose, Yinyan Tang, Michelle R. Arkin, Adam R. Renslo
Publikováno v:
Journal of the American Chemical Society, vol 145, iss 18
Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase
Autor:
Kurt Van Horn, Dongju Wang, Daniel Medina-Cleghorn, Peter Lee, Clifford Bryant, Chad Altobelli, Priyadarshini Jaishankar, Kevin Leung, Raymond Ng, Andrew Ambrose, Yinyan Tang, Michelle Arkin, Adam Renslo
The caspases are a family of cysteine dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human disease. Classical chemical tools to study caspase function lack selectivity for specific caspas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8fdd89adc22c828bf880205eb77877
https://doi.org/10.26434/chemrxiv-2022-5wfm6
https://doi.org/10.26434/chemrxiv-2022-5wfm6
Publikováno v:
Biochemistry, vol 61, iss 21
Autophagy is a catabolic cellular process in which unwanted proteins and organelles are degraded by lysosomes. It is characterized by the formation of the double-membrane autophagosome decorated with LC3B, a protein that mediates autophagosomal fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6cb437186d7238e4077a03b381fed1
https://escholarship.org/uc/item/7wj9254m
https://escholarship.org/uc/item/7wj9254m
Publikováno v:
Biotechnology and Applied Biochemistry. 69:160-165
Acute myocardial infarction (AMI) is the heart attack happening when the blood flow is terminated to the heart muscles. C-reactive protein (CRP) level is raising significantly in AMI patients after the onset of symptom; also, temporal variations of C