Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yinyan Ma"'
Autor:
Karin Nagasaki, Atsuhiro Nagasaki, Jocelyn M. Taylor, Bernice D. Kear, Yinyan Ma, Martha J. Somerman, Oksana Gavrilova
Publikováno v:
Frontiers in Dental Medicine, Vol 4 (2023)
IntroductionBone sialoprotein (BSP) is a key regulator of mineralized tissue formation. Previously, we generated BSP-KAE knock-in mice (KAEKI mice) by substituting a non-function KAE (lysine-alanine-glutamic acid) for the integrin-binding RGD (argini
Externí odkaz:
https://doaj.org/article/37648c3c60474d0c84008dea64c34a93
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Drug-resistant fungal infections are emerging as an important clinical problem. In general, antifungal resistance results from increased target expression or mutations within the target protein sequence. However, the molecular mechanisms of non-drug
Externí odkaz:
https://doaj.org/article/bcb4db8ab06b46e0b09dc6beb09adcce
Autor:
Lin Jia, Yinyan Ma, Jamie Haywood, Long Jiang, Bingzhong Xue, Hang Shi, Paul A. Dawson, Liqing Yu
Publikováno v:
Cells, Vol 10, Iss 12, p 3468 (2021)
Niemann–Pick C1-like 1 (NPC1L1) mediates intestinal uptake of dietary and biliary cholesterol and is the target of ezetimibe, a cholesterol absorption inhibitor used to treat hypercholesterolemia. Genetic deletion of NPC1L1 or ezetimibe treatment p
Externí odkaz:
https://doaj.org/article/4fafef83412742538ce8897a2e0d1533
Autor:
Youngshim Choi, Hyunsu Shin, Ziwei Tang, Yute Yeh, Yinyan Ma, Anil K. G. Kadegowda, Huan Wang, Long Jiang, Rakesh K. Arya, Ling Chen, Bingzhong Xue, Hang Shi, Oksana Gavrilova, Liqing Yu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13361 (2021)
The heart primarily uses fatty acids as energy substrates. Adipose lipolysis is a major source of fatty acids, particularly under stress conditions. In this study, we showed that mice with selective inactivation of the lipolytic coactivator comparati
Externí odkaz:
https://doaj.org/article/2284118371384300a8bc7a8a1c2210fd
Autor:
Juanjuan Ou, Hongming Miao, Yinyan Ma, Feng Guo, Jia Deng, Xing Wei, Jie Zhou, Ganfeng Xie, Hang Shi, Bingzhong Xue, Houjie Liang, Liqing Yu
Publikováno v:
Cell Reports, Vol 9, Iss 5, Pp 1798-1811 (2014)
Summary: How cancer cells shift metabolism to aerobic glycolysis is largely unknown. Here, we show that deficiency of α/β-hydrolase domain-containing 5 (Abhd5), an intracellular lipolytic activator that is also known as comparative gene identificat
Externí odkaz:
https://doaj.org/article/88b671cba9a14b0bb96891907b3adf05
Autor:
Hongming Miao, Juanjuan Ou, Yinyan Ma, Feng Guo, Zhenggang Yang, Melvin Wiggins, Chaohong Liu, Wenxia Song, Xianlin Han, Miao Wang, Qiang Cao, Bik-Ho Florence Chung, Dan Yang, Houjie Liang, Bingzhong Xue, Hang Shi, Lixia Gan, Liqing Yu
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 223-235 (2014)
Overnutrition activates a proinflammatory program in macrophages to induce insulin resistance (IR), but its molecular mechanisms remain incompletely understood. Here, we show that saturated fatty acid and lipopolysaccharide, two factors implicated in
Externí odkaz:
https://doaj.org/article/acb5b8f3cff046ff8a75b6451cb9d3da
Publikováno v:
Forests, Vol 10, Iss 8, p 632 (2019)
The normalization of data by choosing suitable reference genes is fundamental for obtaining accurate and reliable results in quantitative real-time polymerase chain reaction (qPCR) analyses. In this study, the expression stability of 12 candidate ref
Externí odkaz:
https://doaj.org/article/91ba1b1ea49e427cb39c6a3b5787e53a
Autor:
Feng Guo, Yinyan Ma, Anil K.G. Kadegowda, Jenna L. Betters, Ping Xie, George Liu, Xiuli Liu, Hongming Miao, Juanjuan Ou, Xiong Su, Zhenlin Zheng, Bingzhong Xue, Hang Shi, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2109-2120 (2013)
Triglyceride (TG) accumulation in hepatocytes (hepatic steatosis) preludes the development of advanced nonalcoholic fatty liver diseases (NAFLDs) such as steatohepatitis, fibrosis, and cirrhosis. Mutations in human Comparative Gene Identification-58
Externí odkaz:
https://doaj.org/article/c612d0766f394fa39435d54e04dc42a4
Autor:
Lin Jia, Yinyan Ma, Shunxing Rong, Jenna L. Betters, Ping Xie, Soonkyu Chung, Nanping Wang, Weiqing Tang, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3135-3144 (2010)
Niemann-Pick C1-Like 1 (NPC1L1) mediates intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to treat hypercholesterolemia in humans. Interestingly, ezetimibe treatment appears to attenua
Externí odkaz:
https://doaj.org/article/a69c908d5d254de2aee222581724fc82
Autor:
J. Mark Brown, Jenna L. Betters, Caleb Lord, Yinyan Ma, Xianlin Han, Kui Yang, Heather M. Alger, John Melchior, Janet Sawyer, Ramesh Shah, Martha D. Wilson, Xiuli Liu, Mark J. Graham, Richard Lee, Rosanne Crooke, Gerald I. Shulman, Bingzhong Xue, Hang Shi, Liqing Yu
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3306-3315 (2010)
Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG) accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due to a skin barrier defect. To study the role of CGI-58 in integrat
Externí odkaz:
https://doaj.org/article/a3b91154d3f44901ab305189eaa5c386