Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yinxian Yang"'
An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases
Autor:
Shenqiang Wang, Ying Zhang, Yanfang Wang, Yinxian Yang, Sheng Zhao, Tao Sheng, Yuqi Zhang, Zhen Gu, Jinqiang Wang, Jicheng Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune diseases. However, the therapeutic effe
Externí odkaz:
https://doaj.org/article/67b256fdb1c74263b347dad3c9232d0e
Autor:
Ying Zhang, Shenqiang Wang, Yinxian Yang, Sheng Zhao, Jiahuan You, Junxia Wang, Jingwei Cai, Hao Wang, Jie Wang, Wei Zhang, Jicheng Yu, Chunmao Han, Yuqi Zhang, Zhen Gu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell st
Externí odkaz:
https://doaj.org/article/9ee1c1ca4aad4b04a1fa02fc50b0b70a
Autor:
Yinxian Yang, Shiyi Zuo, Linxiao Li, Xiao Kuang, Jinbo Li, Bingjun Sun, Shujun Wang, Zhonggui He, Jin Sun
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 6, Pp 784-793 (2021)
Ferroptosis is a new mode of cell death, which can be induced by Fenton reaction-mediated lipid peroxidation. However, the insufficient H2O2 and high GSH in tumor cells restrict the efficiency of Fenton reaction-dependent ferroptosis. Herein, a self-
Externí odkaz:
https://doaj.org/article/b18f00af445d45a69bb77d1f9a0e1f6a
Autor:
Lingxiao Li, Shiyi Zuo, Fudan Dong, Tian Liu, Yanlin Gao, Yinxian Yang, Xin Wang, Jin Sun, Bingjun Sun, Zhonggui He
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 3, Pp 337-349 (2021)
Homodimeric prodrug-based self-assembled nanoparticles, with carrier-free structure and ultrahigh drug loading, is drawing more and more attentions. Homodimeric prodrugs are composed of two drug molecules and a pivotal linkage. The influence of the l
Externí odkaz:
https://doaj.org/article/1d4cafde6b31468cacf79f4fb432bcd4
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 4, Pp 344-352 (2017)
Azilsartan (AZL), a poorly soluble drug, was considered to be fit for nanocrystals to improve its solubility. Our study intended to prepare AZL nanocrystals by means of bead milling method. Eight stabilizers or their binary combination and the millin
Externí odkaz:
https://doaj.org/article/7372ee3229f949d38d5ce7201ca77a87
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 329 (2020)
The traditional iron chelator deferoxamine (DFO) has been widely used in the treatment of iron overload disease. However, DFO has congenital disadvantages, including a very short circular time and non-negligible toxicity. Herein, we designed a novel
Externí odkaz:
https://doaj.org/article/e4cadeca6e3046e681d9ece48d8c78f1
Structure–Activity Relationship of pH-Sensitive Doxorubicin-Fatty Acid Prodrug Albumin Nanoparticles
Autor:
Yinxian Yang, Xiuhong Li, Jiaxuan Song, Lingxiao Li, Qing Ye, Shiyi Zuo, Tian Liu, Fudan Dong, Xiaohong Liu, Zhonggui He, Bingjun Sun, Jin Sun
Publikováno v:
Nano Letters. 23:1530-1538
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3323d68a902986c9b867ab93c4111509
https://doi.org/10.1021/acs.nanolett.2c04976
https://doi.org/10.1021/acs.nanolett.2c04976
Autor:
Yinxian Yang, Yanfang Wang, Yuejun Yao, Shenqiang Wang, Yuqi Zhang, Gianpietro Dotti, Jicheng Yu, Zhen Gu
Publikováno v:
Matter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c14d44a059ed384710c30dc7c7bec4
https://doi.org/10.1016/j.matt.2023.04.026
https://doi.org/10.1016/j.matt.2023.04.026
Autor:
Yingli, Wang, Jiang, Yu, Dan, Li, Liwen, Zhao, Bingjun, Sun, Jiamei, Wang, Zhenjie, Wang, Shuang, Zhou, Menglin, Wang, Yinxian, Yang, Hongzhuo, Liu, Haotian, Zhang, Qingzhi, Lv, Qikun, Jiang, Zhonggui, He, Yongjun, Wang
Publikováno v:
Journal of Controlled Release. 341:812-827
The combination of chemotherapy with the immune checkpoint blockade (ICB) therapy is bringing a tremendous hope in the treatment of malignant tumors. However, the treatment efficacy of the existing chemo-immunotherapy is not satisfactory due to the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b3a58228b2237529ece9b30b2d48be
https://doi.org/10.1016/j.jconrel.2021.12.023
https://doi.org/10.1016/j.jconrel.2021.12.023
Publikováno v:
Angewandte Chemie (International ed. in English).
Protein and peptide drugs are predominantly administered by injection to achieve high bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug delivery with minimal invasiveness and high adherence represent attracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f77a34e0dbdf3a374d5b322ba73ce78
https://pubmed.ncbi.nlm.nih.gov/36478123
https://pubmed.ncbi.nlm.nih.gov/36478123