Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yinshuang Chen"'
Autor:
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)
Abstract Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC. Fucosyltransferase 8 (FUT8) is a potential therapeutic target w
Externí odkaz:
https://doaj.org/article/7a9c042799264e70a9230d15a9ae936a
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Obesity is a global epidemic and overwhelming evidence indicates that it is a risk factor for numerous cancers, including hepatocellular carcinoma (HCC), the third leading cause of cancer-related deaths worldwide. Obesity-associated hepatic tumorigen
Externí odkaz:
https://doaj.org/article/e7955e56341d45fa93c0bf1fb00b357c
Autor:
Yawen Zhang, Mengmeng Wang, Fanyi Meng, Man Yang, Yinshuang Chen, Xuqin Guo, Weiwei Wang, Yifan Zhu, Yundi Guo, Chunlai Feng, Shen Tian, Hongjian Zhang, Huanqiu Li, Jing Sun, Weipeng Wang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents ta
Externí odkaz:
https://doaj.org/article/11ae711ee50748e1b4fcd20539d8e368
Autor:
Yinshuang Chen, Man Yang, Fanyi Meng, Yawen Zhang, Mengmeng Wang, Xuqin Guo, Jie Yang, Hongjian Zhang, Haiyang Zhang, Jing Sun, Weipeng Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
SRSF3, an important member of the serine/arginine-rich protein (SRp) family, is highly expressed in various tumors and plays an important role in tumor cell proliferation, migration and invasion. However, it is still unclear whether SRSF3 is involved
Externí odkaz:
https://doaj.org/article/6fa7f039fcf54225bfe4dcf2bde55187
Autor:
Mengxi Chen, Shuang Wang, Qi Zhang, Yawen Zhang, Mengmeng Wang, Xuqing Guo, Yinshuang Chen, Hongjian Zhang, Haiyang Zhang, Weipeng Wang
Publikováno v:
ACS Sustainable Chemistry & Engineering. 10:7020-7030
Publikováno v:
Investigational New Drugs. 39:1267-1274
The families of miR-34 and miR-449 share the same seed region. However, the members showed differential effects on the expression of B7-H3 and PD-L1 in HCT-116 cells. Using miR-34a as a template, the non-seed region was modified by nucleotide alterat
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2247-2259
Although a number of studies have revealed the important roles of miR-34a in cancer, the regulatory roles of miR-34a in cancer immune response remain largely unknown. Our present study demonstrated a mechanism underlying miR-34a-mediated cancer immun
Autor:
Mengmeng Wang, Xuqin Guo, Man Yang, Yawen Zhang, Fanyi Meng, Yinshuang Chen, Mengxi Chen, Tian Qiu, Jiawei Li, Zhi Li, Qi Zhang, Fang Xu, Haiyang Zhang, Weipeng Wang
Publikováno v:
Biochemical pharmacology. 199
Clinically, 5-fluorouracil (5-Fu) is a first-line drug for the treatment of patients with colorectal cancer (CRC). However, chemoresistance to 5-Fu-based chemotherapy is a leading obstacle in achieving effective treatment for CRC, especially microsat
Publikováno v:
Oncology Letters
Serine/arginine-rich splicing factor 3 (SRSF3; also known as SRp20), an important member of the family of SRSFs, is abnormally expressed in tumors, resulting in aberrant splicing of hub genes, such as CD44, HER2, MDM4, Rac family small GTPase 1 and t
Autor:
Chunxia Zhang, Fanyi Meng, Weipeng Wang, Fuchao Li, Yawen Zhang, Weichang Chen, Yinshuang Chen, Man Yang
Publikováno v:
Cancer immunology, immunotherapy : CII. 70(2)
B7-H3, an important co-inhibitor, is abnormally highly expressed in a variety of malignancies. The antibodies targeting B7-H3 have exhibited beneficial therapeutic effects in clinical trials. Therefore, discovery of the regulatory factors in B7-H3 ex