Synthesis and anti-rheumatoid arthritis activities of 3-(4-aminophenyl)-coumarin derivatives

Autor: Yuhang Miao, Jie Yang, Yinling Yun, Jie Sun, Xiaojing Wang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 450-461 (2021)

Rheumatoid arthritis is a chronic systemic disease characterised by an unknown aetiology of inflammatory synovitis. A large number of studies have shown that synoviocytes show tumour-like dysplasia in the pathological process of RA, and the changes i

Externí odkaz: https://doaj.org/article/ecca5ccddb144ce9a5649bfc621c2e1a

Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer’s disease agents

Autor: Jie Yang, Yinling Yun, Yuhang Miao, Jie Sun, Xiaojing Wang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 805-814 (2020)

Multi-target drugs can better address the cascade of events involved in oxidative stress and the reduction in cholinergic transmission that occur in Alzheimer’s disease than cholinesterase inhibitors alone. We synthesised a series of 3-arylbenzofur

Externí odkaz: https://doaj.org/article/970ba2fd2a964aac88222406a9542fb6

Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents

Autor: Xiao-Jing Wang, Yuhang Miao, Sun Xiaoya, Jie Sun, Yinling Yun

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1345-1355 (2021)

Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044e9e0d879fc4b9b750881bc36858c4
https://doi.org/10.1080/14756366.2021.1940993

Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer’s disease agents

Autor: Yuhang Miao, Jie Sun, Yinling Yun, Jie Yang, Wang Xiaojing

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 805-814 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry

Multi-target drugs can better address the cascade of events involved in oxidative stress and the reduction in cholinergic transmission that occur in Alzheimer’s disease than cholinesterase inhibitors alone. We synthesised a series of 3-arylbenzofur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bebb1e4681ace9f3748aebe32ea3be6
https://doaj.org/article/970ba2fd2a964aac88222406a9542fb6

Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents

Autor: Yuhang Miao, Jie Yang, Yinling Yun, Jie Sun, Xiao-Jing Wang

Publikováno v: Bioorganicmedicinal chemistry letters. 30(4)

Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c084f0177f1c78fbf99ad50b63749be
https://pubmed.ncbi.nlm.nih.gov/31882295