Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yinli Gao"'
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2905-2922 (2022)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1H-indole derivat
Externí odkaz:
https://doaj.org/article/f8f315b4d41341e19ffcb1ea0a529a41
Publikováno v:
Journal of Computational Biophysics and Chemistry. 22:189-205
The Hsp90 family has been extensively studied as a promising target against cancer and neurodegenerative diseases due to its crucial role in protein maturation and transport. However, the toxic and side effects such as cardiotoxicity and ocular toxic
Autor:
Haihan Liu, Baichun Hu, Jiasi Luan, Yuqing Sun, Shizun Wang, Weixai Li, Lu Chen, Hanxun Wang, Yinli Gao, Jian Wang
Publikováno v:
Journal of Molecular Modeling. 29
Publikováno v:
Expert Opinion on Therapeutic Patents. 31:977-987
Introduction: The Ser/Thr protein kinase PAK4 is a downstream regulator of Cdc42, mediating cytoskeleton remodeling, and cell motility, and inhibiting apoptosis and transcriptional regulation. Nowa...
Autor:
Peilu Song, Fan Zhao, Dahong Li, Jiqiang Qu, Miao Yao, Yuan Su, Hanxun Wang, Miaomiao Zhou, Yujie Wang, Yinli Gao, Feng Li, Dongmei Zhao, Fengjiao Zhang, Yu Rao, Mingyu Xia, Haitao Li, Jian Wang, Maosheng Cheng
Publikováno v:
Acta pharmaceutica Sinica. B. 12(6)
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for cancer progression. Guided by X-ray crystallography and structure-based optimization, we report a novel subseries of C-3-substituted 6-ethynyl-1
Autor:
Yin, Sun, Lin, Wang, Yu, Sun, Jingkai, Wang, Yanli, Xue, Tianxiao, Wu, Wenbo, Yin, Qiaohua, Qin, Yixiang, Sun, Hanxun, Wang, Yinli, Gao, Huali, Yang, Dongmei, Zhao, Maosheng, Cheng
Publikováno v:
European Journal of Medicinal Chemistry. 243:114714
Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase involved in regulating cell mitosis and centriole duplication, and has emerged as a therapeutic target for treating multiple cancers. At first, the design and in vitro validation of PLK4
Autor:
Hanxiao Shang, Rongwu Xiang, Fei Zhai, Kai Ma, Yinli Gao, Yuan Wang, Ya Zeng, Shen Xiao, Luna Yang
Publikováno v:
Computers in biology and medicine. 138
Hepatitis B (HB) is a globally prevalent infectious disease caused by the HB virus. Xiaochaihu decoction (XCHD) is a classic herbal formula with a long history of clinical application in treating HB. Although the anti-HB activity of XCHD has been rep
Autor:
Fengjiao Zhang, Hanxun Wang, Jian Wang, Lanlan Sun, Wenbin Dai, Jianping Mao, Shuya Zhang, Yinli Gao
Publikováno v:
Archives of Toxicology. 93:1297-1309
Humans are exposed to hydroquinone (HQ) via diet, smoking, occupation, and even via inhalation of polluted air. Given its preferential distribution in kidney and liver, the impact of biotransformation on the nephrotoxicity and hepatotoxicity of HQ wa
Autor:
Yinli, Gao, Hanxun, Wang, Lanlan, Shen, Hanqing, Xu, Minghui, Deng, Maosheng, Cheng, Jian, Wang
Publikováno v:
Bioorganic Chemistry. 123:105769
The inhibition of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) interaction by monoclonal antibodies (mAbs) has achieved promising outcomes in cancer immunotherapy. Due to the inherent deficiencies of mAbs drugs, such as high co
Autor:
Di Wu, Xiaohui Geng, Fengjiao Zhang, Johnson Joseph, Jian Wang, Baichun Hu, Yinli Gao, Ying Wang
5-hydroxytryptamine 2A (5-HT2A) receptor is emerging as an important target for numerous psychoactive drugs due to its imperative roles in psychological diseases. In fact, multiple 5-HT2A receptor antagonists were developed to treat numerous psychiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c115edddb489e7172fdbe6bac80a4