Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yinkai Duan"'
Autor:
Haofeng Wang, Qi Yang, Xiaoce Liu, Zili Xu, Maolin Shao, Dongxu Li, Yinkai Duan, Jielin Tang, Xianqiang Yu, Yumin Zhang, Aihua Hao, Yajie Wang, Jie Chen, Chenghao Zhu, Luke Guddat, Hongli Chen, Leike Zhang, Xinwen Chen, Biao Jiang, Lei Sun, Zihe Rao, Haitao Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases,
Externí odkaz:
https://doaj.org/article/a8a939a48a4d430796d03a0396af8a49
Autor:
Mengmeng Lin, Xudong Zeng, Yinkai Duan, Zinan Yang, Yuanyuan Ma, Haitao Yang, Xiuna Yang, Xiang Liu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-7 (2023)
Abstract SARS-CoV-2 poses an unprecedented threat to the world as the causative agent of the COVID-19 pandemic. Among a handful of therapeutics developed for the prevention and treatment of SARS-CoV-2 infection, ensitrelvir is the first noncovalent a
Externí odkaz:
https://doaj.org/article/c99a42094b8d4648bb74233b8cdf41f9
Autor:
Dawei Ma, Yinkai Duan, Ruxue Zhang, Qi Zhang, Chao Peng, Kailin Yang, Yao Zhao, Leike Zhang, Haitao Yang, Maolin Shao, Yan Zhu, Lu Feng, Xiuna Yang, Chao Fang, Jinyi Zhao, Zihe Rao, Xiangbo Zhao, Haofeng Wang
Publikováno v:
Protein & Cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bea8dca7501f1d7a9436918c91ff44
https://doi.org/10.1007/s13238-021-00883-2
https://doi.org/10.1007/s13238-021-00883-2
Autor:
Wen Cui, Haojun Huang, Yinkai Duan, Zhi Luo, Haofeng Wang, Tenan Zhang, Henry C Nguyen, Wei Shen, Dan Su, Xi Li, Xiaoyun Ji, Haitao Yang, Wei Wang
Publikováno v:
Protein & Cell.
The current monkeypox outbreak has caused over 73,000 global cases, but the effective treatments are very limited. The dual specific phosphatase (H1) from monkeypox antagonizes the immune response and is crucial for viral replication, making it an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a54db5c9b48d6c116571afd687905f9
https://doi.org/10.1093/procel/pwac051
https://doi.org/10.1093/procel/pwac051
Autor:
Sho Iketani, Hiroshi Mohri, Bruce Culbertson, Seo Jung Hong, Yinkai Duan, Maria I. Luck, Medini K. Annavajhala, Yicheng Guo, Zizhang Sheng, Anne-Catrin Uhlemann, Stephen P. Goff, Yosef Sabo, Haitao Yang, Alejandro Chavez, David D. Ho
Publikováno v:
bioRxiv
Nirmatrelvir, an oral antiviral targeting the 3CL protease of SARS-CoV-2, has been demonstrated to be clinically useful in reducing hospitalization or death due to COVID-191,2. However, as SARS-CoV-2 has evolved to become resistant to other therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366633746ed68c77c4581ff710563a55
https://pubmed.ncbi.nlm.nih.gov/36032976
https://pubmed.ncbi.nlm.nih.gov/36032976
Autor:
Haitao Yang, Jing Yu, Lin Han, Zhenming Jin, Lei Sun, Yinkai Duan, Chao Peng, Yao Zhao, Leike Zhang, Tian You, Jun Wang, Xiaoyan Pan, Weijuan Shang, Hangtian Guo, Xiuna Yang, Luke W. Guddat, Ying Lei, Yifang Sun, Qianying Liu, Gengfu Xiao, Yan Wu, Wenqing Xu, Zihe Rao, Xiaoyu Du, Chenghao Zhu, Kailin Yang
Publikováno v:
Protein & Cell
A new coronavirus (SARS-CoV-2) has been identified as the etiologic agent for the COVID-19 outbreak. Currently, effective treatment options remain very limited for this disease; therefore, there is an urgent need to identify new anti-COVID-19 agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aef53f15a2175ea54a5a7cc9398006d
https://doi.org/10.1007/s13238-021-00836-9
https://doi.org/10.1007/s13238-021-00836-9
Publikováno v:
Biochemical and Biophysical Research Communications
The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1c90d67cbe35ef6d346427f60e8bb8
https://doi.org/10.1016/j.bbrc.2020.10.091
https://doi.org/10.1016/j.bbrc.2020.10.091
Autor:
Yao Zhao, Yan Zhu, Xiang Liu, Zhenming Jin, Yinkai Duan, Qi Zhang, Chengyao Wu, Lu Feng, Xiaoyu Du, Jinyi Zhao, Maolin Shao, Bing Zhang, Xiuna Yang, Lijie Wu, Xiaoyun Ji, Luke W. Guddat, Kailin Yang, Zihe Rao, Haitao Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(16)
Significance COVID-19 is a deadly rampaging infectious disease with over 480 million cases worldwide. Unfortunately, effective therapies remain very limited. Novel antiviral agents are urgently needed to combat this global healthcare crisis. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9751bf686aa1c8cde9c990e13ed102b
https://pubmed.ncbi.nlm.nih.gov/35380892
https://pubmed.ncbi.nlm.nih.gov/35380892
Autor:
Jun Cui, Ruijiao Ti, Wang Wei, Wen Cui, Elisabeth Braun, Daniel Sauter, Na Li, Yanyan Zheng, Cheng Chen, Haitao Yang, Xiu Li, Jinhong Tang, Benjamin T Slater, Frank Kirchhoff, Lei Zhang, Yinkai Duan, Yunjie Xiao, Xiaoyun Ji, Yong Xiong, Bin Wang, Dominik Hotter, Qingxiang Liu, Zefang Wang
Publikováno v:
Proc Natl Acad Sci U S A
Guanylate-binding proteins (GBPs) form a family of dynamin-related large GTPases which mediate important innate immune functions. They were proposed to form oligomers upon GTP binding/hydrolysis, but the molecular mechanisms remain elusive. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b756b9852a376ab7f731ff96dc090
https://doi.org/10.1073/pnas.2022269118
https://doi.org/10.1073/pnas.2022269118
Autor:
Chen Zhu, Haofeng Wang, Jing Yu, Zhenming Jin, Yinkai Duan, Yao Zhao, Leike Zhang, Xiang Liu, Tianyu Hu, Yuan Sun, Xiaoyu Du, Haitao Yang, Zihe Rao, Yan Wu, Bing Zhang, Luke W. Guddat, Xiuna Yang, Kailin Yang, Yan Zhu, Gengfu Xiao, Xiaobao Yang
Publikováno v:
Nature Structural & Molecular Biology
The antineoplastic drug Carmofur was shown to inhibit SARS-CoV-2 main protease (Mpro). Here the X-ray crystal structure of Mpro in complex with Carmofur reveals that the carbonyl reactive group of Carmofur is covalently bound to catalytic Cys145, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb339eb0eb25d4ab0f986634bab2dc9b
https://doi.org/10.1101/2020.04.09.033233
https://doi.org/10.1101/2020.04.09.033233
