Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yingsi Chen"'
Autor:
Yingsi Chen, Feifei Xu, Xiaoxuan Xiao, Huiqin Chi, Yuefei Lai, Xiuqin Lin, Qiuyun Li, Jia Song, Weiliang Wu, Ziyin Li, Xingfen Yang
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 271, Iss , Pp 115928- (2024)
Nephrotoxicity is a common adverse effect induced by various chemicals, necessitating the development of reliable toxicity screening models for nephrotoxicity assessment. In this study, we assessed a group of nephrotoxicity indicators derived from di
Externí odkaz:
https://doaj.org/article/4d0d1ecf331a480d9193ab883305611f
Autor:
Feifei XU, Yueqi LI, Jun LIN, Yuefei LAI, Ziyin LI, Xiuqin LIN, Yingsi CHEN, Weiliang WU, Xingfen YANG
Publikováno v:
Shipin gongye ke-ji, Vol 43, Iss 14, Pp 293-300 (2022)
In order to assess the health risk of consumption of local planted vegetables in high-level Cd contaminated region, inductively coupled plasma mass spectrometry (ICP-MS) was employed to determine the elements of Cd, Mg, K, Ca, Cu and Zn in the common
Externí odkaz:
https://doaj.org/article/20613be992da436584dae685e97be79f
Publikováno v:
Case Studies on Transport Policy. 12:101014
Publikováno v:
Maritime Business Review. 7:222-238
PurposeShip chandlers’ trucks are now facing challenges owing to their job characteristics, which will lead to low productivity of trucks, congestions and pollutions at the port. The aim of this paper is to identify important causes and the effects
Autor:
Ziyin Li, Weizuo Liao, Xinxin Yin, Lili Liu, Zhiqiang Zhao, Xiaodan Lu, Feifei Xu, Xiuqin Lin, Yingsi Chen, Jia Song, Zhini He, Qinzhi Wei, Weiliang Wu, Yongning Wu, Xingfen Yang
Publikováno v:
Food and Chemical Toxicology. 172:113601
Cadmium accumulates in the kidney and causes inflammation. The NLRP3 inflammasome has been linked to the pathogenesis of inflammation. Hyperoside (HYP) possesses potent nephroprotective properties against of kidney injury. This study aimed to researc
Autor:
Shirley Li, Kelly M. George, Shelley K. Gleason, Charles Wartchow, Binh Thanh Vu, Hong Qian, Ann C. Petersen, Qing-Fen Gan, Lin Gao, Gabriel Stephen Deems, Linghao Niu, Nanda Beatini, Johannes C. Hermann, Arjun Narayanan, John Menke, Nathan Robert Scott, Nancy-Ellen Haynes, Yingsi Chen
Publikováno v:
ACS Medicinal Chemistry Letters. 4:197-200
Organic impurities in compound libraries are known to often cause false-positive signals in screening campaigns for new leads, but organic impurities do not fully account for all false-positive results. We discovered inorganic impurities in our scree
Autor:
Rebecca Taub, Weiya Yun, Toni Whittard, David Robert Bolin, Yimin Qian, Shiming Li, Paul Gillespie, Sonja Kazmer, Yingsi Chen, Mushtaq Ahmad, Stanley Wertheimer, Karin Conde-Knape
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7205-7209
In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Furthe
Autor:
Stanley Wertheimer, Lee Apostle Mcdermott, Stuart Hayden, Weiya Yun, Yingsi Chen, Anjula Pamidimukkala, Rebecca Taub, Kuo-Sen Huang, Toni Whittard, Liang Guo, Shiming Li, Jenny Tan, Fariborz Firooznia, Adrian Wai-Hing Cheung, David Robert Bolin, Nicholas Marcopulos, Yimin Qian, Karin Conde-Knape, Mushtaq Ahmad, Gwendolyn Ramsey, Cristina M. Rondinone, Jefferson Wright Tilley, Matthew Michael Hamilton
Publikováno v:
Journal of Medicinal Chemistry. 54:2433-2446
Diacylglycerol acyltransferase-1 (DGAT-1) is the enzyme that catalyzes the final and committed step of triglyceride formation, namely, the acylation of diacylglycerol with acyl coenzyme A. DGAT-1 deficient mice demonstrate resistance to weight gain o
Autor:
Jin-Jun Liu, Christophe Michoud, Feng Chi, Yang Wen, Qing Xiang, Nam T. Le, Shaoqing Chen, Nicole Jackson, Jian Ping Lou, Li Chen, Chunlin Zhao, Achyutharao Sidduri, Louis Portland, Lyubomir T. Vassilev, Fred Konzelmann, Yingsi Chen, Christian Tovar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2134-2138
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this
Autor:
Sazzad Hussain, Brian Higgins, Packman Kathryn E, Bernardo Felix, Hong Qian, Tom Nevins, Kenneth Kolinsky, Yingsi Chen, Roger Blain, David C. Heimbrook, Allen John Lovey, Wanda DePinto, Christian Tovar, Melissa Smith, Petra Goelzer, Xuefeng Yin, Leopoldo Luistro, Xin-Jie Chu, Qing Xiang, Rachid Hamid
Publikováno v:
Molecular Cancer Therapeutics. 5:2644-2658
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of distinct cyclin-dependent kinase (CDK) complexes results in escape of cells from cell cycle control, leading to unrestricted