Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Yingna Xu"'
Autor:
Yingna Xu, Qiaofeng Liu, Chuan-Wei Chen, Qiuying Wang, Tianyuan Du, Run Yu, Qingtong Zhou, Dehua Yang, Ming-Wei Wang
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35362- (2024)
Mahvash disease, a rare autosomal recessive metabolic disorder characterized by biallelic loss-of-function mutations in the glucagon receptor gene (GCGR), induces significant pancreatic hyperglucagonemia, resulting in α-cell hyperplasia and occasion
Externí odkaz:
https://doaj.org/article/e714057373e445b8b25705183134faf9
Autor:
Wenbo Feng, Qingtong Zhou, Xianyue Chen, Antao Dai, Xiaoqing Cai, Xiao Liu, Fenghui Zhao, Yan Chen, Chenyu Ye, Yingna Xu, Zhaotong Cong, Hao Li, Shi Lin, Dehua Yang, Ming-Wei Wang
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes including energy homeostasis, inflammation and skin pigmentation through five MCR subtypes (MC1R
Externí odkaz:
https://doaj.org/article/190a738404d84ae2b0a114c2e0d96b21
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19219- (2023)
Circular RNAs (circRNAs) are important non-coding RNAs (ncRNAs) involved in the development of multiple human diseases, especially cancers. circRNA_0084043 is significantly involved in the progression of melanoma. However, whether circRNA_0084043 is
Externí odkaz:
https://doaj.org/article/e940ebb00cdc4a18b36cfe3b17db37d2
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
Autor:
Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Li-Hua Zhao, Tian Xia, Yi Jiang, H. Eric Xu, Dehua Yang, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Vasoactive intestinal polypeptide receptor 2 (VIP2R) is involved in immunity. Here, the authors report two cryo-EM structures of the VIP2R–Gs in complex with the endogenous peptide ligand PACAP27, revealing a unique interaction mode between PACAP27
Externí odkaz:
https://doaj.org/article/6b052b3574ad402e83e39dc0f3c97931
Autor:
Fenghui Zhao, Kaini Hang, Qingtong Zhou, Lijun Shao, Hao Li, Wenzhuo Li, Shi Lin, Antao Dai, Xiaoqing Cai, Yanyun Liu, Yingna Xu, Wenbo Feng, Dehua Yang, Ming-Wei Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 10/10/2023, Vol. 120 Issue 41, p1-12, 27p
Autor:
Xiao Liu, Qingtong Zhou, Jonathan R. Hart, Yingna Xu, Su Yang, Dehua Yang, Peter K. Vogt, Ming-Wei Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that perform multiple and important cellular functions. The protein investigated here belongs to class IA of the PI3Ks; it is a dimer consisting of a catalytic subunit, p110α, and a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ace4881738541dcf4b0340014f9817
https://doi.org/10.1073/pnas.2215621119
https://doi.org/10.1073/pnas.2215621119
Circular RNAs (circRNAs) are important non-coding RNAs (ncRNAs) involved in the development of multiple human diseases, especially cancers. circRNA_0084043 is significantly involved in the progression of melanoma. However, whether circRNA_0084043 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aed127502bd1e1668a9123e72e1a678
https://doi.org/10.21203/rs.3.rs-2160496/v1
https://doi.org/10.21203/rs.3.rs-2160496/v1
Autor:
Jonathan R. Hart, Xiao Liu, Chen Pan, Anyi Liang, Lynn Ueno, Yingna Xu, Alexandra Quezada, Xinyu Zou, Su Yang, Qingtong Zhou, Steve Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, Tian Xia, Wenqing Shui, Dehua Yang, Peter K. Vogt, Ming-Wei Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(38)
Nanobodies and chemical cross-linking were used to gain information on the identity and positions of flexible domains of PI3Kα. The application of chemical cross-linking mass spectrometry (CXMS) facilitated the identification of the p85 domains BH,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55133b6f8776690dcbfd4a081e658996
https://pubmed.ncbi.nlm.nih.gov/36095215
https://pubmed.ncbi.nlm.nih.gov/36095215
Publikováno v:
Journal of Cancer
Glioma is a pervasive malignancy and the main cause of cancer-related deaths worldwide. Circular RNA is an important subject of cancer research, and its role and function in glioma are poorly understood. This study demonstrated that hsa_circ_0091581
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fd28076e583bf3a50d912b14a1d969
https://doi.org/10.7150/jca.55558
https://doi.org/10.7150/jca.55558
Autor:
Jonathan R. Hart, Su Yang, Xiao Liu, Yingna Xu, Xinyu Zou, Huibing Zhang, Qingtong Zhou, Tian Xia, Yan Zhang, Dehua Yang, Ming-Wei Wang, Peter K. Vogt
Publikováno v:
Cancer Research. 82:671-671
Many solid tumors have alterations in phosphoinositide 3-kinase (PI3K) signaling. These can occur through mutation of the p110alpha and p85alpha proteins of PI3Kalpha itself as well as through alterations to upstream receptor tyrosine kinases (RTKs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87fe217d9720288f1a8065004305e0f
https://doi.org/10.1158/1538-7445.am2022-671
https://doi.org/10.1158/1538-7445.am2022-671