Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Autor: Christian K. Holm, Stine H. Rahbek, Hans Henrik Gad, Rasmus O. Bak, Martin R. Jakobsen, Zhaozaho Jiang, Anne Louise Hansen, Simon K. Jensen, Chenglong Sun, Martin K. Thomsen, Anders Laustsen, Camilla G. Nielsen, Kasper Severinsen, Yingluo Xiong, Dara L. Burdette, Veit Hornung, Robert Jan Lebbink, Mogens Duch, Katherine A. Fitzgerald, Shervin Bahrami, Jakob Giehm Mikkelsen, Rune Hartmann, Søren R. Paludan

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Stimulator of interferon genes (STING) is known to be involved in defence against DNA viruses, but its role in the control of RNA viruses remains poorly explored. Here the authors show that STING participates in an innate immune response to RNA virus

Externí odkaz: https://doaj.org/article/00f2e460d4a44590a591e3a422a9f087

Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation

Autor: Jiaoyan Lv, Ting Liu, Yingluo Xiong, Xinyi Cui, Rui He, Wenjing Li

Publikováno v: Cytokine. 111

BLT1, the primary functional receptor of Leukotriene B4 (LTB4), is involved in tissue inflammation by mediating leukocyte recruitment, and recently LTB4-dependent inflammation was reported to promote lung tumor growth. Exposure to diesel exhaust part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756b27beee977acf021ff7c2bbd978a2
https://pubmed.ncbi.nlm.nih.gov/29884308

Leukotriene B4-leukotriene B4receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8+T cells

Autor: Yingluo Xiong, Wei Yang, Bingji Li, Jiaoyan Lv, Linlin Zou, Rui He, Lina Zhao

Publikováno v: Immunology. 146:50-58

Leukotriene B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells. Contact dermatitis is a common inflammatory skin disease characterized by skin oedema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c788cb2ba0fcce27b3262705770ac9a
https://doi.org/10.1111/imm.12478

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses

Autor: Jakob Giehm Mikkelsen, Dara Burdette, Martin K. Thomsen, Kasper Severinsen, Mogens Duch, Hans Henrik Gad, Anders Laustsen, Martin R. Jakobsen, Robert Jan Lebbink, Chenglong Sun, Camilla G. Nielsen, Zhaozaho Jiang, Katherine A. Fitzgerald, Anne Louise Hansen, Rasmus O. Bak, Stine H. Rahbek, Yingluo Xiong, Søren R. Paludan, Shervin Bahrami, Rune Hartmann, Veit Hornung, Simon K. Jensen, Christian K. Holm

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Holm, C K, Rahbek, S H, Gad, H H, Bak, R O, Jakobsen, M R, Jiang, Z, Hansen, A L, Jensen, S K, Sun, C, Thomsen, M K, Laustsen, A, Nielsen, C G, Severinsen, K, Xiong, Y, Burdette, D L, Hornung, V, Lebbink, R J, Duch, M, Fitzgerald, K A, Bahrami, S, Mikkelsen, J G, Hartmann, R & Paludan, S R 2016, ' Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses ', Nature Communications, vol. 7, 10680 . https://doi.org/10.1038/ncomms10680
Nature Communications [E], 7. Nature Publishing Group

Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses. During infection with DNA viruses STING is activated downstream of cGAMP synthase (cGAS) to induce type I inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a72d1a69772d92aeae8e805274e4553
https://doi.org/10.1038/ncomms10680

A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis

Autor: Hejian Zou, Rui He, Minrui Liang, Yingluo Xiong, Wei Yang, Xiangjun Chen, Ming Guan, Jiaoyan Lv, Linlin Zou

Publikováno v: Laboratory investigation; a journal of technical methods and pathology. 95(3)

Daily subcutaneous (sc) injection of bleomycin (BLM) causes dermal fibrosis but rarely causes lung changes in mice. There are also significant disadvantages to this traditional model for systemic sclerosis, including a variable distribution of lesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cf668a7a21030f3651f54d1cf6d586
https://pubmed.ncbi.nlm.nih.gov/25502178