Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Yingli Gu"'
Autor:
Yingli Gu, Alexander Pope, Charlene Smith, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes, Thomas Shoff, Korbin M. Kleczko, Judith Frydman, Leslie M. Thompson, William C. Mobley, Chengbiao Wu
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106502- (2024)
Synaptic changes are early manifestations of neuronal dysfunction in Huntington's disease (HD). However, the mechanisms by which mutant HTT protein impacts synaptogenesis and function are not well understood. Herein we explored HD pathogenesis in the
Externí odkaz:
https://doaj.org/article/9bef532de4e646788a3015cb4732bb13
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cathy Hou, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a genetic mutation in the huntingtin gene (HTT). Here, cryo electron tomography provides insights into the morphology of the cells derived from patients with HD and mouse mod
Externí odkaz:
https://doaj.org/article/27dd4928dbf643889186e8bd55e8a97e
Autor:
Yingli Gu, Flora Guerra, Mingzheng Hu, Alexander Pope, Kijung Sung, Wanlin Yang, Simone Jetha, Thomas A. Shoff, Tessanya Gunatilake, Owen Dahlkamp, Linda Zhixia Shi, Fiore Manganelli, Maria Nolano, Yue Zhou, Jianqing Ding, Cecilia Bucci, Chengbiao Wu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
The Rab7V162M mutation associated with Charcot Marie Tooth 2B peripheral neuropathy causes mitochondrial fragmentation in patient-derived fibroblasts and primary cultured dorsal root ganglion sensory neurons from E18 mouse embryos.
Externí odkaz:
https://doaj.org/article/ff7f26e091d241bdb1ca3d45ed50c24d
Autor:
Suzhen Lin, André D.G. Leitão, Savannah Fang, Yingli Gu, Sophia Barber, Rhiannon Gilliard-Telefoni, Alfredo Castro, Kijung Sung, Ruinan Shen, Jazmin B. Florio, Michael L. Mante, Jianqing Ding, Brian Spencer, Eliezer Masliah, Robert A. Rissman, Chengbiao Wu
Publikováno v:
Neurobiology of Disease, Vol 178, Iss , Pp 106010- (2023)
Mutations or triplication of the alpha synuclein (ASYN) gene contribute to synucleinopathies including Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Recent evidence suggests that ASYN also plays an impor
Externí odkaz:
https://doaj.org/article/ce172def23994913ad183ff932d3046b
Autor:
Veronica Gomez Godinez, Vikash Morar, Christopher Carmona, Yingli Gu, Kijung Sung, Linda Z. Shi, Chengbiao Wu, Daryl Preece, Michael W. Berns
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Laser-induced shockwaves (LIS) can be utilized as a method to subject cells to conditions similar to those occurring during a blast-induced traumatic brain injury. The pairing of LIS with genetically encoded biosensors allows researchers to monitor t
Externí odkaz:
https://doaj.org/article/920ee3d1862a49d794d75ff90d2dab8c
Autor:
Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire Cecile Bacon-Brenes, Thomas Shoff, Korbin M. Kleczko, Judith Frydman, Leslie M. Thompson, William C. Mobley, Chengbiao Wu
Huntington’s disease (HD) results from a CAG repeat expansion in the gene for Huntington (HTT) resulting in expansion of the polyglutamine (Q) tract in the mutant protein (mHTT). Synaptic changes are early manifestations of neuronal dysfunction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a20b811e6f65924361379af71a60cd9d
https://doi.org/10.1101/2022.11.25.517123
https://doi.org/10.1101/2022.11.25.517123
Autor:
Gong-Her Wu, Charlene Smith-Geater, Jesús G. Galaz-Montoya, Yingli Gu, Sanket R. Gupte, Ranen Aviner, Patrick G. Mitchell, Joy Hsu, Ricardo Miramontes, Keona Q. Wang, Nicolette R. Geller, Cristina Danita, Lydia-Marie Joubert, Michael F. Schmid, Serena Yeung, Judith Frydman, William Mobley, Chengbiao Wu, Leslie M. Thompson, Wah Chiu
Huntington’s Disease (HD) is caused by an expanded CAG repeat in the huntingtin gene, yielding a Huntingtin protein with an expanded polyglutamine tract. Patient-derived induced pluripotent stem cells (iPSCs) can help understand disease; however, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313875dd4f14f417b710f2f394017c4
https://doi.org/10.1101/2022.03.26.485912
https://doi.org/10.1101/2022.03.26.485912
Autor:
Jiaolin Zheng, Zhuo Li, Hong Zhao, Ling Yun, Hongmei Gao, Jing Zhao, Shuo Yang, Longxuan Li, Yuan Fu, Dandan Li, YingLi Gu, Shuo Li
Publikováno v:
Aging (Albany NY)
Alzheimer's disease (AD) is associated with the accumulation and deposition of a beta-amyloid (Αβ) peptide in the brain, resulting in increased neuroinflammation and synaptic dysfunction. Intranasal delivery of targeted drugs to the brain represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba285123288f3246b1ee8d6a8be1c76f
https://doi.org/10.18632/aging.102970
https://doi.org/10.18632/aging.102970
Autor:
Veronica Gomez Godinez, Christopher Carmona, Chengbiao Wu, Daryl Preece, Kijung Sung, Vikash Morar, Linda Z. Shi, Yingli Gu, Michael W. Berns
Publikováno v:
Optical Trapping and Optical Micromanipulation XVIII.
Laser induced shockwave (LIS) can be utilized to subject neuronal cells to conditions similar to those occurring during a blast induced traumatic brain injury. We utilized a 532nm Coherent Flare laser to induce a shockwave near cells which had been t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b431d33bf00def15b871737b6f22c55
https://doi.org/10.1117/12.2595803
https://doi.org/10.1117/12.2595803
Autor:
Fiore Manganelli, Jianqing Ding, Flora Guerra, Kijung Sung, Cecilia Bucci, Wanlin Yang, Chengbiao Wu, Yue Zhou, Yingli Gu, Tessanya Gunatilake, Mingzheng Hu, Simone Jetha, Maria Nolano, Linda Zhixia Shi, Thomas A. Shoff, Alexander Pope, Owen Dahlkamp
Recent evidence has uncovered an important role of Rab7 in regulating mitochondrial morphology and function. Missense mutation(s) of Rab7 underlies the pathogenesis of Charcot Marie Tooth 2B (CMT2B) peripheral neuropathy. Herein, we investigated how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd06d4e65514e20a0663e113e543107d
https://doi.org/10.1101/2021.07.28.454213
https://doi.org/10.1101/2021.07.28.454213