Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Yingkun Qiu"'
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
ObjectivesThyroid dysfunction is commonly associated with the risk of infertility in both females and males. However, recent randomized controlled trials have demonstrated that thyroid function levels in females are not significantly related to infer
Externí odkaz:
https://doaj.org/article/470a37e9059548c1903b44a376d7071b
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionPrevious observational studies have reported a positive correlation between obesity and susceptibility to hypothyroidism; however, there is limited evidence from alternative methodologies to establish a causal link.MethodsWe investigated
Externí odkaz:
https://doaj.org/article/d1f6fe84dd6e4dbaa37b4d41301638ba
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23828- (2024)
Objective: To explore the potential clinical and prognostic significance of Homo sapiens solute carrier family 35 member F2 (SLC35F2) in the context of lung adenocarcinoma (LUAD). Methods: The expression pattern of SLC35F2 in LUAD tissues and normal
Externí odkaz:
https://doaj.org/article/e8b7f1ec5b4d41a1854283f1493e762d
Autor:
Fengming He, Jun Chen, Taige Zhao, Qiaoqiong Wu, Na Yin, Xiumei Wang, Yijing Zhong, Xiaodan Guo, YingKun Qiu, Baicun Li, Meijuan Fang, Zhen Wu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Nur77 modulators have emerged as a promising therapeutic approach for hepatocellular carcinoma. In this study, a structure-based rational drug design approach was used to design and synthesise a series of 4-((8-hydroxy-2-methylquinolin-4-yl)amino)ben
Externí odkaz:
https://doaj.org/article/ad13e54480a744138d8c675f5f6cad66
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-9 (2020)
Abstract Efficient and accurate prediction of molecular properties, such as lipophilicity and solubility, is highly desirable for rational compound design in chemical and pharmaceutical industries. To this end, we build and apply a graph-neural-netwo
Externí odkaz:
https://doaj.org/article/2e341dc48d624ee0b01f065af9d41781
Autor:
Biqian Fu, Shengyan Xi, Yanhui Wang, Xiangyang Zhai, Yanan Wang, Yuewen Gong, Yangxinzi Xu, Jiaqi Yang, Yingkun Qiu, Jing Wang, Dawei Lu, Shuqiong Huang
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a traditional Chinese medical formula that has been shown in clinical practice to relieve side effects of chemotherapy and improve quality of life for cancer patients. In order to understand the mechani
Externí odkaz:
https://doaj.org/article/3fe77e8aa7c64e38ab0155edfc6fab2e
Autor:
Jun Chen, Taige Zhao, Fengming He, Yijing Zhong, Susu Wang, Ziqing Tang, Yingkun Qiu, Zhen Wu, Meijuan Fang
Publikováno v:
European Journal of Medicinal Chemistry. 254:115341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40f7fb43b3c301cd406f12625c81c743
https://doi.org/10.1016/j.ejmech.2023.115341
https://doi.org/10.1016/j.ejmech.2023.115341
Autor:
Yuqing Qian, Mingtao Ao, Boqun Li, Zhijian Kuang, Xiumei Wang, Yin Cao, Jiayi Li, Yingkun Qiu, Kaiqiang Guo, Meijuan Fang, Zhen Wu
Publikováno v:
Bioorganic chemistry. 129
JMJD6 is a member of the JmjC domain-containing family and has been identified as a promising therapeutic target for treating estrogen-induced and triple-negative breast cancer. To develop novel anti-breast cancer agents, we synthesized a class of N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f1fe24be47f63246371a42babe1b31
https://pubmed.ncbi.nlm.nih.gov/36116323
https://pubmed.ncbi.nlm.nih.gov/36116323
Autor:
Mingtao Ao, Jianyu Zhang, Yuqing Qian, Boqun Li, Xiumei Wang, Jun Chen, Yuxiang Zhang, Yin Cao, Yingkun Qiu, Yang Xu, Zhen Wu, Meijuan Fang
Publikováno v:
Bioorganic chemistry. 120
In continuing our study on discovering new Nur77-targeting anti-inflammatory agents with natural skeletons, we combined adamantyl group and hydroxamic acid moiety with flavonoid nucleus, synthesized three series of flavonoid derivatives with a simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0986858d43c9fe92e2a71ccfbd253e2c
https://pubmed.ncbi.nlm.nih.gov/35121551
https://pubmed.ncbi.nlm.nih.gov/35121551
Autor:
Jingbo Qin, Xiaohui Chen, Weihao Liu, Jun Chen, Weirong Liu, Yongzhen Xia, Zhehui Li, Mingyu Li, Shaojuan Wang, Quan Yuan, Yingkun Qiu, Zhen Wu, Meijuan Fang
Publikováno v:
European Journal of Medicinal Chemistry. 244:114849
Encouraged by our previous findings and in continuation of our ongoing study project in designing and synthesis of novel Nur77-targeting anti-cancer agents, a series of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bee52553d5aaad33983f432fbd3a45
https://doi.org/10.1016/j.ejmech.2022.114849
https://doi.org/10.1016/j.ejmech.2022.114849