Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yingkai Liang"'
Autor:
Kingshuk Dutta, Ritam Das, Jing Ling, Rafael Mayoral Monibas, Ester Carballo-Jane, Ahmet Kekec, Danqing Dennis Feng, Songnian Lin, James Mu, Robert Saklatvala, S. Thayumanavan, Yingkai Liang
Publikováno v:
ACS Omega, Vol 5, Iss 28, Pp 17531-17542 (2020)
Externí odkaz:
https://doaj.org/article/e07bb7861fcc44ce9fd240665f45f633
Autor:
Dmitri A. Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D. Feng, Pei Huo, Christina Madsen-Duggan, Christopher R. Moyes, Ravi P. Nargund, Terri Kelly, Xiaoping Zhang, Ester Carballo-Jane, Judith Gorski, Peter Zafian, Mo Qatanani, Niels Kaarsholm, Fanyu Meng, Xiujuan Jia, Keun-Joong Lee, Weixun Wang, Sherrie Xu, Michael J. Hohn, Michael J. Iammarino, Mark A. McCoy, Grace A. Okoh, Yingkai Liang, Scott A. Hollingsworth, Mark D. Erion, David E. Kelley, Robert M. Garbaccio, Amy Zhang, James Mu, Songnian Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:5593-5605
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic treatment. These molecules were designed as dimers of native in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159d29e98accab17d5d9616e44812b0d
https://doi.org/10.1021/acs.jmedchem.1c02073
https://doi.org/10.1021/acs.jmedchem.1c02073
Publikováno v:
Journal of Pharmaceutical Sciences. 109:922-926
Formulations that can increase the dissociation of insulin oligomers into monomers/dimers are important considerations in the development of ultra-rapid-acting insulins with faster onset and shorter duration of actions. Here we present a novel strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c932e2ccec63ec636359977daf3c34
https://doi.org/10.1016/j.xphs.2019.07.025
https://doi.org/10.1016/j.xphs.2019.07.025
Autor:
Bradley T. Falk, Marc Andre Bailly, Yingkai Liang, Mark A. McCoy, Laurence Fayadat-Dilman, Dmitri A. Pissarnitski, Dennis Feng, Songnian Lin, Fahimeh Raoufi, Ahmet Kekec, Lin Yan
Publikováno v:
ChemBioChem. 21:315-319
NMR measurements of rotational and translational diffusion are used to characterize the solution behavior of a wide variety of therapeutic proteins and peptides. The timescales of motions sampled in these experiments reveal complicated intrinsic solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd05f3038162fadb318559950a3e8ce
https://doi.org/10.1002/cbic.201900296
https://doi.org/10.1002/cbic.201900296
Autor:
Robert Saklatvala, Kingshuk Dutta, Songnian Lin, James Mu, Sankaran Thayumanavan, Ester Carballo-Jane, Jing Ling, Yingkai Liang, Rafael Mayoral Monibas, Ahmet Kekec, Ritam Das, Danqing Dennis Feng
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 28, Pp 17531-17542 (2020)
ACS Omega, Vol 5, Iss 28, Pp 17531-17542 (2020)
Due to their relatively large molecular sizes and delicate nature, biologic drugs such as peptides, proteins, and antibodies often require high and repeated dosing, which can cause undesired side effects and physical discomfort in patients and render
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be908efa8e19f7d87d41ebf2ff2e7c1a
https://pubmed.ncbi.nlm.nih.gov/32715238
https://pubmed.ncbi.nlm.nih.gov/32715238
Publikováno v:
Macromolecules. 50:483-502
Biomaterials have been extensively used to leverage beneficial outcomes in various therapeutic applications, such as providing spatial and temporal control over the release of therapeutic agents in drug delivery as well as engineering functional tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1a2e5d77d1ed8fc17a50f0ca808e770
https://doi.org/10.1021/acs.macromol.6b02389
https://doi.org/10.1021/acs.macromol.6b02389
Publikováno v:
Journal of pharmaceutical sciences. 109(1)
Formulations that can increase the dissociation of insulin oligomers into monomers/dimers are important considerations in the development of ultra-rapid-acting insulins with faster onset and shorter duration of actions. Here we present a novel strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::604278a504bacf36c4948e29f818c6da
https://pubmed.ncbi.nlm.nih.gov/31449814
https://pubmed.ncbi.nlm.nih.gov/31449814
Publikováno v:
Chembiochem : a European journal of chemical biology. 20(7)
Characterizing changes to structure and behavior is an important aspect of therapeutic protein development. NMR spectroscopy is well suited to study interactions and higher-order structure that could impact biological function and safety. We used NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba81ad34a27112c8ce33e267c6789c0d
https://pubmed.ncbi.nlm.nih.gov/30515922
https://pubmed.ncbi.nlm.nih.gov/30515922
Autor:
Yingkai Liang, Slobodanka D. Manceva, R. Mark Jones, Jessica A. Chichester, Kristi L. Kiick, Megan V. Coffin
Publikováno v:
Journal of Biomedical Materials Research Part A. 104:113-123
In this study, hydrophilic and hydrolytically degradable poly (ethylene glycol) (PEG) hydrogels were formed via Michael-type addition and employed for sustained delivery of a monoclonal antibody against the protective antigen of anthrax. Taking advan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c028d0d91dc67cbb12cf2c8890db7ab
https://doi.org/10.1002/jbm.a.35545
https://doi.org/10.1002/jbm.a.35545
Publikováno v:
Macromolecules. 50(2)
Biomaterials have been extensively used to leverage beneficial outcomes in various therapeutic applications, such as providing spatial and temporal control over the release of therapeutic agents in drug delivery as well as engineering functional tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc58c5c779a4af2d5fb31f74ffa50c81
https://pubmed.ncbi.nlm.nih.gov/29151616
https://pubmed.ncbi.nlm.nih.gov/29151616