Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Yinghui Sui"'
Autor:
Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin R. Larsen, Gitte Lund Christensen, Nils Billestrup
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-16 (2023)
Summary Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islet
Externí odkaz:
https://doaj.org/article/ff71f86b08274f6ea980a103f69cf1c4
Autor:
Matthew Wortham, Fenfen Liu, Austin R. Harrington, Johanna Y. Fleischman, Martina Wallace, Francesca Mulas, Medhavi Mallick, Nicholas K. Vinckier, Benjamin R. Cross, Joshua Chiou, Nisha A. Patel, Yinghui Sui, Carolyn McGrail, Yesl Jun, Gaowei Wang, Ulupi S. Jhala, Roland Schüle, Orian S. Shirihai, Mark O. Huising, Kyle J. Gaulton, Christian M. Metallo, Maike Sander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Adaptation of the islet β cell insulin-secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we have shown that nutrient-stimulated histone acetylati
Externí odkaz:
https://doaj.org/article/b59ff5cf14e54435855ccfd8a98f4b14
Autor:
Wen Jin, Francesca Mulas, Bjoern Gaertner, Yinghui Sui, Jinzhao Wang, Ileana Matta, Chun Zeng, Nicholas Vinckier, Allen Wang, Kim-Vy Nguyen-Ngoc, Joshua Chiou, Klaus H. Kaestner, Kelly A. Frazer, Andrea C. Carrano, Hung-Ping Shih, Maike Sander
Publikováno v:
iScience, Vol 21, Iss , Pp 681-694 (2019)
Summary: Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs) are im
Externí odkaz:
https://doaj.org/article/a9bcb8fa84904ad59b0a30cfe0ed2af3
Autor:
Matthew Wortham, Jacqueline R. Benthuysen, Martina Wallace, Jeffrey N. Savas, Francesca Mulas, Ajit S. Divakaruni, Fenfen Liu, Verena Albert, Brandon L. Taylor, Yinghui Sui, Enrique Saez, Anne N. Murphy, John R. Yates, III, Christian M. Metallo, Maike Sander
Publikováno v:
Cell Reports, Vol 25, Iss 10, Pp 2904-2918.e8 (2018)
Summary: Pancreatic β cell physiology changes substantially throughout life, yet the mechanisms that drive these changes are poorly understood. Here, we performed comprehensive in vivo quantitative proteomic profiling of pancreatic islets from juven
Externí odkaz:
https://doaj.org/article/61d4a21deb7a4e80ab3f521ac9d4dddb
Autor:
Adriana Ibarra, Michala Prause, Lars Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin Larsen, Gitte Christensen, Nils Billestrup
Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased expression of several key beta cell genes. The pro-inflammatory factor BMP-2 is upregulated in islets of Lan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f9f8ec132504ff618720aa7da2bbda
https://doi.org/10.21203/rs.3.rs-2254065/v1
https://doi.org/10.21203/rs.3.rs-2254065/v1
Autor:
Kyle J. Gaulton, Sebastian Preissl, Serina Huang, Chun Zeng, Yinghui Sui, David U. Gorkin, Allison Deogaygay, Jee Yun Han, Parul Kudtarkar, Jinzhao Wang, Ying Sun, Michael Schlichting, Michael Miller, Joshua Chiou, Robert Mendez, Rongxin Fang, Mei-Lin Okino, Yunjiang Qiu, Maike Sander, Zhang Cheng
Publikováno v:
Nature Genetics. 53:455-466
Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type–specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36b1d539bb4784e0f0476c73e8b287d5
https://doi.org/10.1038/s41588-021-00823-0
https://doi.org/10.1038/s41588-021-00823-0
Autor:
Allen Wang, Wen Jin, Andrea C. Carrano, Kelly A. Frazer, Jinzhao Wang, Kim-Vy Nguyen-Ngoc, Francesca Mulas, Yinghui Sui, Ileana Matta, Nicholas Vinckier, Chun Zeng, Hung Ping Shih, Klaus H. Kaestner, Maike Sander, Joshua Chiou, Bjoern Gaertner
Publikováno v:
iScience, Vol 21, Iss, Pp 681-694 (2019)
iScience
iScience
Summary Pancreatic endocrine cell differentiation is orchestrated by the action of transcription factors that operate in a gene regulatory network to activate endocrine lineage genes and repress lineage-inappropriate genes. MicroRNAs (miRNAs) are imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968c672cee2d914d1bb9ffbe883d993c
http://www.sciencedirect.com/science/article/pii/S2589004219304444
http://www.sciencedirect.com/science/article/pii/S2589004219304444
Autor:
Wortham M, Cross Br, Harrington Ar, Maike Sander, Wallace M, Gaulton Kj, Furong Liu, Yinghui Sui, Christian M. Metallo, Francesca Mulas, Nikit Patel, Orian S. Shirihai, Mark O. Huising, Nicholas Vinckier, Fleischman Jy, Joshua Chiou, Ulupi S. Jhala
Adaptation of the islet β-cell insulin secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we show that nutrient-stimulated histone acetylation pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64f9fb974be35c4ed196ba535249ed8
Autor:
Yunjiang Qiu, Sebastian Preissl, Yinghui Sui, Jee Yun Han, Maike Sander, Jinzhao Wang, Allison Deogaygay, Serina Huang, Chun Zeng, Joshua Chiou, Parul Kudtarkar, Michael Schlichting, Mei-Lin Okino, Zhang Cheng, Kyle J. Gaulton, Ying Sun, Rongxin Fang, David U. Gorkin
Genetic risk variants for complex, multifactorial diseases are enriched incis-regulatory elements. Single cell epigenomic technologies create new opportunities to dissect cell type-specific mechanisms of risk variants, yet this approach has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e96ced6bba52736631ced69d7fdacd
Autor:
Joshua, Chiou, Chun, Zeng, Zhang, Cheng, Jee Yun, Han, Michael, Schlichting, Michael, Miller, Robert, Mendez, Serina, Huang, Jinzhao, Wang, Yinghui, Sui, Allison, Deogaygay, Mei-Lin, Okino, Yunjiang, Qiu, Ying, Sun, Parul, Kudtarkar, Rongxin, Fang, Sebastian, Preissl, Maike, Sander, David U, Gorkin, Kyle J, Gaulton
Publikováno v:
Nature genetics. 53(4)
Single-nucleus assay for transposase-accessible chromatin using sequencing (snATAC-seq) creates new opportunities to dissect cell type-specific mechanisms of complex diseases. Since pancreatic islets are central to type 2 diabetes (T2D), we profiled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::faaca42815d4e89f8fdb36f2e75be85f
https://pubmed.ncbi.nlm.nih.gov/33795864
https://pubmed.ncbi.nlm.nih.gov/33795864