Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Yinghui Rong"'
Publikováno v:
Antibodies, Vol 13, Iss 1, p 14 (2024)
Bispecific antibodies have gained increasing popularity as therapeutics as they enable novel activities that cannot be achieved with monospecific antibodies. Some of the most popular bispecific formats are molecules in which two Fab arms with differe
Externí odkaz:
https://doaj.org/article/c23df2f5d0214866b8a5840765d9f0ed
Autor:
Yinghui Rong, Fernando J. Torres-Velez, Dylan Ehrbar, Jennifer Doering, Renjie Song, Nicholas J. Mantis
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 4, Pp 793-807 (2020)
Ricin toxin, a plant-derived, mannosylated glycoprotein, elicits an incapacitating and potentially lethal inflammatory response in the airways following inhalation. Uptake of ricin by alveolar macrophages (AM) and other pulmonary cell types occurs vi
Externí odkaz:
https://doaj.org/article/a155ae3ee1894daca689a4eb8cc9ba1e
Autor:
Yueru Li, Yinghui Rong, Lisui Bao, Ben Nie, Guang Ren, Chen Zheng, Rajesh Amin, Robert D. Arnold, Ramesh B. Jeganathan, Kevin W. Huggins
Publikováno v:
Lipids in Health and Disease, Vol 16, Iss 1, Pp 1-10 (2017)
Abstract Background Increased consumption of omega-3 (ω-3) fatty acids found in cold-water fish and fish oil has been reported to protect against obesity. A potential mechanism may be through reduction in adipocyte differentiation. Stearidonic acid
Externí odkaz:
https://doaj.org/article/dfca0a7188754f1c86a96188f3f3c6a4
Autor:
Yinghui Rong, Michael Pauly, Adrian Guthals, Henry Pham, Dylan Ehrbar, Larry Zeitlin, Nicholas J. Mantis
Publikováno v:
Toxins, Vol 12, Iss 4, p 215 (2020)
PB10 IgG1, a monoclonal antibody (MAb) directed against an immunodominant epitope on the enzymatic subunit (RTA) of ricin toxin (RT), has been shown to passively protect mice and non-human primates from an aerosolized lethal-dose RT challenge. Howeve
Externí odkaz:
https://doaj.org/article/fa52682f77ed4722b6040fc129dc91c5
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT Inhalation of ricin toxin is associated with the onset of acute respiratory distress syndrome (ARDS), characterized by hemorrhage, inflammatory exudates, and tissue edema, as well as the nearly complete destruction of the lung epithelium. He
Externí odkaz:
https://doaj.org/article/9690467bf65245f5b7c42182c82a6e1e
Autor:
Yinghui Rong, Greta Van Slyke, David J Vance, Jennifer Westfall, Dylan Ehrbar, Nicholas J Mantis
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180999 (2017)
Ricin toxin's binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of ricin within mammalian cells. Structurally, RTB consists of two globular domains, each divide
Externí odkaz:
https://doaj.org/article/63bbca9885b9451daf4c5617ccea8d6c
Autor:
Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi My Thi Nguyen, Michael J. Rudolph, David Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis
Publikováno v:
Antibodies, Vol 7, Iss 4, p 45 (2018)
In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concer
Externí odkaz:
https://doaj.org/article/08b529d18940415d831f6223da371ea8
Publikováno v:
Toxins, Vol 9, Iss 12, p 378 (2017)
As part of an effort to engineer ricin antitoxins and immunotherapies, we previously produced and characterized a collection of phage-displayed, heavy chain-only antibodies (VHHs) from alpacas that had been immunized with ricin antigens. In our initi
Externí odkaz:
https://doaj.org/article/5d982aa4d6ba48edbf5710e1ab5c36bc
Autor:
Lindsey E. Tolman, Jennifer L. Yates, Yinghui Rong, Claire Reynolds-Peterson, Dylan Ehrbar, Fernando J. Torres-Velez, Nicholas J. Mantis
Publikováno v:
ImmunoHorizons. 6:324-333
Inhalation of ricin toxin (RT) elicits profuse inflammation and cell death within the upper and lower airways, ultimately culminating in acute respiratory distress syndrome. We previously reported that the effects of pulmonary RT exposure in mice are
Autor:
Nicholas J. Mantis, Yinghui Rong, Jennifer Doering, Fernando J Torres-Velez, Dylan J. Ehrbar, Renjie Song
Publikováno v:
Hum Vaccin Immunother
Ricin toxin, a plant-derived, mannosylated glycoprotein, elicits an incapacitating and potentially lethal inflammatory response in the airways following inhalation. Uptake of ricin by alveolar macrophages (AM) and other pulmonary cell types occurs vi