Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Yingdong Zhu"'
Autor:
Shuwei Hu, Fathima N. Cassim Bawa, Yingdong Zhu, Xiaoli Pan, Hui Wang, Raja Gopoju, Yanyong Xu, Yanqiao Zhang
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The crosstalk between adipose tissue and the liver is finely controlled to maintain metabolic health. Yet, how adipose tissue controls toxic free fatty acid overflow into the liver remains incompletely understood. Here, we show that adipocyt
Externí odkaz:
https://doaj.org/article/a1c1e6c18b764bafb8515ca34423153b
Autor:
Fathima N. Cassim Bawa, Yanyong Xu, Raja Gopoju, Noel‐Marie Plonski, Amy Shiyab, Shuwei Hu, Shaoru Chen, Yingdong Zhu, Kavita Jadhav, Takhar Kasumov, Yanqiao Zhang
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2665-2675 (2022)
Abstract All‐trans retinoic acid (AtRA) is an active metabolite of vitamin A that influences many biological processes in development, differentiation, and metabolism. AtRA functions through activation of retinoid acid receptors (RARs). AtRA is sho
Externí odkaz:
https://doaj.org/article/694b54558d4041fab6f981560f167922
Autor:
Yingdong Zhu, Shuwei Hu, Xiaoli Pan, Raja Gopoju, Fathima N. Cassim Bawa, Liya Yin, Yanyong Xu, Yanqiao Zhang
Publikováno v:
Cells, Vol 12, Iss 15, p 2009 (2023)
Histone deacetylase Sirtuin 6 (SIRT6) regulates many biological processes. SIRT6 is known to regulate hepatic lipid metabolism and inhibit the development of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the role of hepatocyte SIR
Externí odkaz:
https://doaj.org/article/3dc9008b6e614a46af09435223a0d867
Autor:
Yanyong Xu, Yingdong Zhu, Fathima Cassim Bawa, Shuwei Hu, Xiaoli Pan, Liya Yin, Yanqiao Zhang
Publikováno v:
Hepatology Communications, Vol 4, Iss 4, Pp 527-539 (2020)
Rodents have at least five carboxylesterase 1 (Ces1) genes, whereas there is only one CES1 gene in humans, raising the question as to whether human CES1 and mouse Ces1 genes share the same functions. In this study, we investigate the role of human CE
Externí odkaz:
https://doaj.org/article/f11ab9a3379741b9a84a02ff49557e1b
Autor:
Yanyong Xu, Yingdong Zhu, Shuwei Hu, Xiaoli Pan, Fathima Cassim Bawa, Helen H. Wang, David Q.-H. Wang, Liya Yin, Yanqiao Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101244- (2021)
Objective: Hepatic miR-34a expression is elevated in diet-induced or genetically obese mice and patients with non-alcoholic steatohepatitis (NASH), yet hepatocyte miR-34a's role in the progression of non-alcoholic fatty liver disease (NAFLD) from non
Externí odkaz:
https://doaj.org/article/c3ec0c6e17764eb18b186d2835ffbcf1
Autor:
Fathima N. Cassim Bawa, Raja Gopoju, Yanyong Xu, Shuwei Hu, Yingdong Zhu, Shaoru Chen, Kavita Jadhav, Yanqiao Zhang
Publikováno v:
Cells, Vol 11, Iss 20, p 3186 (2022)
Retinoic acid signaling plays an important role in regulating lipid metabolism and inflammation. However, the role of retinoic acid receptor alpha (RARα) in atherosclerosis remains to be determined. In the current study, we investigated the role of
Externí odkaz:
https://doaj.org/article/6c039e90dc7b4cfc99ed8ce304069eef
Autor:
Yanyong Xu, Yingdong Zhu, Kavita Jadhav, Yuanyuan Li, Huihui Sun, Liya Yin, Takhar Kasumov, Xiaoli Chen, Yanqiao Zhang
Publikováno v:
Hepatology Communications, Vol 3, Iss 6, Pp 763-775 (2019)
Hepatocytes are the major source of hepatic lipocalin‐2 (LCN2), which is up‐regulated in response to inflammation, injury, or metabolic stress. So far, the role of hepatocyte‐derived LCN2 in the development of nonalcoholic fatty liver disease (
Externí odkaz:
https://doaj.org/article/c08aac34ab054a0884565426f4595956
Autor:
Kavita Jadhav, Yang Xu, Yanyong Xu, Yuanyuan Li, Jiesi Xu, Yingdong Zhu, Luciano Adorini, Yoon Kwang Lee, Takhar Kasumov, Liya Yin, Yanqiao Zhang
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 131-140 (2018)
Objectives: Activation of the bile acid (BA) receptors farnesoid X receptor (FXR) or G protein-coupled bile acid receptor (GPBAR1; TGR5) improves metabolic homeostasis. In this study, we aim to determine the impact of pharmacological activation of bi
Externí odkaz:
https://doaj.org/article/a7dd88a9f8734838834387a9fb649759
Autor:
Yingdong Zhu, Jack C. Vaughn
Publikováno v:
Frontiers in Plant Science, Vol 9 (2018)
Messenger RNA (mRNA) polyadenylation is an indispensable step during post-transcriptional pre-mRNA processing for most genes in eukaryotes. The usage of one poly(A) site over another is known as alternative polyadenylation (APA). APA has been implica
Externí odkaz:
https://doaj.org/article/c817166e7043409fb16b9bb0b94cc70b
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54677 (2013)
Our previous study found that [6]-shogaol, a major bioactive component in ginger, is extensively metabolized in cancer cells and in mice. It is unclear whether these metabolites retain bioactivity. The aim of the current study is to synthesize the ma
Externí odkaz:
https://doaj.org/article/bda964c101ea497d91c429bea227fc95