Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Yingdong, Zhao"'
Autor:
Mariam M. Konaté, Julia Krushkal, Ming-Chung Li, Li Chen, Yuri Kotliarov, Alida Palmisano, Rini Pauly, Qian Xie, P. Mickey Williams, Lisa M. McShane, Yingdong Zhao
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background With poor prognosis and high mortality, pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Standard of care therapies for PDAC have included gemcitabine for the past three decades, although resistance
Externí odkaz:
https://doaj.org/article/8450290fb1bd45a187afecbd4534732f
Autor:
Julia Krushkal, Yingdong Zhao, Kyle Roney, Weimin Zhu, Alan Brooks, Deborah Wilsker, Ralph E. Parchment, Lisa M. McShane, James H. Doroshow
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
ABSTRACTHistone deacetylases (HDACs) and sirtuins (SIRTs) are important epigenetic regulators of cancer pathways. There is a limited understanding of how transcriptional regulation of their genes is affected by chemotherapeutic agents, and how such t
Externí odkaz:
https://doaj.org/article/76cdf0bfff0e453b87e8b5bd10e9b649
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-21 (2023)
Abstract Background Lung cancer is reported to be the leading cause of death in males and females, globally. Increasing evidence highlights the paramount importance of Lactate dehydrogenase D (LDHD) in different types of cancers, though it’s role i
Externí odkaz:
https://doaj.org/article/4d196c136bfa4f85ae29954069698959
Autor:
Lipei Shao, Rongye Shi, Yingdong Zhao, Hui Liu, Alexander Lu, Jinxia Ma, Yihua Cai, Tatyana Fuksenko, Alejandra Pelayo, Nirali N. Shah, James N. Kochenderfer, Scott M. Norberg, Christian Hinrichs, Steven L. Highfill, Robert P Somerville, Sandhya R. Panch, Ping Jin, David F. Stroncek
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Clinical CAR T-cell therapy using integrating vector systems represents a promising approach for the treatment of hematological malignancies. Lentiviral and γ-retroviral vectors are the most commonly used vectors in the manufactu
Externí odkaz:
https://doaj.org/article/32a010a258d84ef0bd9faf982f28cee6
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Proteomic data provide a direct readout of protein function, thus constituting an information-rich resource for prognostic and predictive modeling. However, protein array data may not fully capture pathway activity due to the limited number
Externí odkaz:
https://doaj.org/article/b6033ef2e3cc459abd2209205a6c2989
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17165 (2023)
The frequency and extent of transgene-mediated cosuppression varies substantially among plant genes. However, the underlying mechanisms leading to strong cosuppression have received little attention. In previous studies, we showed that the expression
Externí odkaz:
https://doaj.org/article/44b414f3fe504ec69b25af41108923ad
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-22 (2022)
Abstract Background Indian natural products have been anecdotally used for cancer treatment but with limited efficacy. To better understand their mechanism, we examined the publicly available data for the activity of Indian natural products in the NC
Externí odkaz:
https://doaj.org/article/28df93c0fd434ba8ae45df83171454ab
Autor:
Lipei Shao, Avinash Iyer, Yingdong Zhao, Rob Somerville, Sandhya Panch, Alejandra Pelayo, David F. Stroncek, Ping Jin
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract CD19 CAR T-cell immunotherapy is a breakthrough treatment for B cell malignancies, but relapse and lack of response remain a challenge. The bone marrow microenvironment is a key factor in therapy resistance, however, little research has been
Externí odkaz:
https://doaj.org/article/170278e8bc4a4436998aae1c377a338a
Autor:
Andra V. Krauze, Yingdong Zhao, Ming-Chung Li, Joanna Shih, Will Jiang, Erdal Tasci, Theresa Cooley Zgela, Mary Sproull, Megan Mackey, Uma Shankavaram, Philip Tofilon, Kevin Camphausen
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1499 (2023)
Background: Glioblastoma (GBM) is the most common brain tumor with an overall survival (OS) of less than 30% at two years. Valproic acid (VPA) demonstrated survival benefits documented in retrospective and prospective trials, when used in combination
Externí odkaz:
https://doaj.org/article/1107fa231d3f4bf78bbde3b7c8957b18
Autor:
Anna E. Coghill, Jianwen Fang, Zhiwei Liu, Chien-Jen Chen, Ruth F. Jarrett, Henrik Hjalgrim, Carla Proietti, Kelly J. Yu, Wan-Lun Hsu, Pei-Jen Lou, Chen-Ping Wang, Yingdong Zhao, Denise L. Doolan, Allan Hildesheim
Publikováno v:
International Journal of Infectious Diseases, Vol 114, Iss , Pp 65-71 (2022)
ABSTRACT: Background: Epstein–Barr virus (EBV) infection contributes to cancers in a fraction of seropositive individuals, but much remains to be learned about variation in EBV-directed humoral immunity in cancer-free adults. Methods: A protein mic
Externí odkaz:
https://doaj.org/article/bb033c0992f74958a4dbcc75d7993452