Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Ying-yong Zhao"'
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 423-435 (2024)
AbstractContext Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation. The gut microbiota, an integral aspect of
Externí odkaz:
https://doaj.org/article/dffa9b791f86462cb7e72491c125877c
Autor:
Hua Miao, Fei Liu, Yan-Ni Wang, Xiao-Yong Yu, Shougang Zhuang, Yan Guo, Nosratola D. Vaziri, Shi-Xing Ma, Wei Su, You-Quan Shang, Ming Gao, Jin-Hua Zhang, Li Zhang, Ying-Yong Zhao, Gang Cao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants in
Externí odkaz:
https://doaj.org/article/f0388e0061014d22b8856082a830360e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionIncreasing evidence shows that hyperactive aryl hydrocarbon receptor (AHR) signalling is involved in renal disease. However, no currently available intervention strategy is effective in halting disease progression by targeting the AHR sig
Externí odkaz:
https://doaj.org/article/38d69408b9c9429dbae744a29076478e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that
Externí odkaz:
https://doaj.org/article/f9900b6d2492448882bedc4e2ce8965d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
Renal fibrosis is increasingly recognized as a global public health problem. Acute kidney injury (AKI) and chronic kidney disease (CKD) both result in renal fibrosis. Oxidative stress and inflammation play central roles in progressive renal fibrosis.
Externí odkaz:
https://doaj.org/article/d868712f4bb941fdad2bb66b12b1baf2
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e20019- (2023)
Considerable achievements were realized in illuminating underlying pathological mechanisms of patients with idiopathic membranous nephropathy (IMN). Although IMN patients are well diagnosed before they reach renal failure, no currently available drug
Externí odkaz:
https://doaj.org/article/aec8ec286241441cbcfa051382bf7efe
Autor:
Ying-Yong Zhao
Publikováno v:
Exploration of Medicine, Vol 3, Iss 3, Pp 260-274 (2022)
Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of these pathological d
Externí odkaz:
https://doaj.org/article/021fbdfdb0594af1866ce028c1f69171
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/7b9939402efb4585b759538c07c2233c
Autor:
Yan-Ni Wang, Hong-Jiao Liu, Li-Li Ren, Ping Suo, Liang Zou, Ya-Mei Zhang, Xiao-Yong Yu, Ying-Yong Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Chronic kidney disease (CKD) is a major worldwide public health problem. The increase in the number of patients with CKD and end-stage kidney disease requesting renal dialysis or transplantation will progress to epidemic proportions in the next sever
Externí odkaz:
https://doaj.org/article/b51879d632fe4c1dbdca778e5abb12c0
Autor:
Yan-Ni Wang, Hao-Yu Feng, Xin Nie, Ya-Mei Zhang, Liang Zou, Xia Li, Xiao-Yong Yu, Ying-Yong Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome among adults, which is the leading glomerular disease that recurs after kidney transplantation. Treatment for MN remained controversial and challenging, partly owing to absenc
Externí odkaz:
https://doaj.org/article/c384392d6f2747ab89902dc6e7d85e82