Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Ying-Xuan Chen"'
Autor:
Hao-Lian Wang, Yan Chen, Yun-Qian Wang, En-Wei Tao, Juan Tan, Qian-Qian Liu, Chun-Min Li, Xue-Mei Tong, Qin-Yan Gao, Jie Hong, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Sirtuin 5 (SIRT5) has been associated to colorectal cancer and metabolic regulation. Here, the authors show that SIRT5 silencing reduces nucleotide availability leading to DNA damage and tumor suppression in colorectal cancer models.
Externí odkaz:
https://doaj.org/article/7c18464faa94426cb04cb22b6b80f0d0
Autor:
Yaqi Gao, Tianhui Zou, Pingping Xu, Yingchao Wang, Yi Jiang, Ying-Xuan Chen, Haoyan Chen, Jie Hong, Jing-Yuan Fang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100850- (2023)
Fusobacterium nucleatum (F. nucleatum) is enriched in colorectal cancer (CRC) tissues and a high amount of F. nucleatum was associated with an immunosuppressive tumor environment. PD-L1 is an important immune checkpoint expressed on tumor cells and p
Externí odkaz:
https://doaj.org/article/93860454e07148a9b4de58b2ea282d71
Autor:
Yimeng Ren, Yun Qian, Luoyan Ai, Yile Xie, Yaqi Gao, Ziyan Zhuang, Jinxian Chen, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Transport protein particle (TRAPP) is a multimeric protein complex regulating membrane trafficking pathways. Here the authors show that TRAPPC4, a core subunit of TRAPP complex, is required for RAB11-mediated recycling of PD-L1, affecting T-cell-medi
Externí odkaz:
https://doaj.org/article/42b747d961694a008ae75ed740330fe4
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Currently, tRNA-derived small RNAs (tsRNAs) are recognized as a novel and potential type of non-coding RNAs (ncRNAs), which participate in various cellular processes and play an essential role in cancer progression. However, tsRNA
Externí odkaz:
https://doaj.org/article/42810800150646029bd227a1d8d2bcc4
Autor:
Pingping Xu, Danfeng Sun, Yaqi Gao, Yi Jiang, Ming Zhong, Gang Zhao, Jinxian Chen, Zheng Wang, Qiang Liu, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Aiming to identify rare high-penetrance mutations in new genes for the underlying predisposition in familial colorectal cancer (CRC), we performed whole-exome sequencing in 24 familial CRCs. Mutations in genes that regulate DNA repair (RMI1, PALB2, F
Externí odkaz:
https://doaj.org/article/17c9840f18f445358304cd56fd1b72de
Publikováno v:
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-6 (2019)
Abstract Background CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel. Case presentation Here, we present a case of 43-year-old female patient suffered chronic abdominal pain for 20 years, and
Externí odkaz:
https://doaj.org/article/59e1218ea0024a13bf6766693c5a26f6
Autor:
Ji-Xuan Han, Zhi-Hang Tao, Yun Qian, Chen-Yang Yu, Jialu Li, Zi-Ran Kang, Shiyuan Lu, Yuanhong Xie, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Chronic inflammation and gut microbiota dysbiosis are risk factors for colorectal cancer. In clinical practice, patients with inflammatory bowel disease (IBD) have a greatly increased risk of developing colitis-associated colorectal cancer (CAC). How
Externí odkaz:
https://doaj.org/article/56dd306dac244497839512d315a15158
Autor:
Qian-Qian Liu, Chun-Min Li, Lin-Na Fu, Hao-Lian Wang, Juan Tan, Yun-Qian Wang, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
The enrichment of Enterotoxigenic Bacteroides fragilis (ETBF) has been identified in CRC patients and associated with worse prognosis. Cancer stem cells (CSCs) play essential roles in CRC development. However, whether ETBF is involved in CSCs regulat
Externí odkaz:
https://doaj.org/article/3f731e6d2133470d8aa10e9a0e38798e
Autor:
Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its d
Externí odkaz:
https://doaj.org/article/8890027318944e53acbc90ea70f0641b
Autor:
Yuan-Hong Xie, Qin-Yan Gao, Guo-Xiang Cai, Xiao-Ming Sun, Tian-Hui Zou, Hui-Min Chen, Si-Yi Yu, Yi-Wen Qiu, Wei-Qi Gu, Xiao-Yu Chen, Yun Cui, Danfeng Sun, Zhan-Ju Liu, San-Jun Cai, Jie Xu, Ying-Xuan Chen, Jing-Yuan Fang
Publikováno v:
EBioMedicine, Vol 25, Iss C, Pp 32-40 (2017)
Objective: Current non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for early and advanced colorectal cancer detection. Design: In the test stage, the r
Externí odkaz:
https://doaj.org/article/b570200e131f40ad8f429df77213d7e1