Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ying-Tzang Tien"'
Autor:
William R Henderson, Xin Ye, Ying Lai, Zhanglin Ni, James G Bollinger, Ying-Tzang Tien, Emil Y Chi, Michael H Gelb
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56172 (2013)
Previous work has shown that disruption of the gene for group X secreted phospholipase A2 (sPLA2-X) markedly diminishes airway hyperresponsiveness and remodeling in a mouse asthma model. With the large number of additional sPLA2s in the mammalian gen
Externí odkaz:
https://doaj.org/article/b4773573adb6453e808decf4ed26381e
Autor:
James G. Bollinger, Xin Ye, Jun Xue, Rob C. Oslund, Michael H. Gelb, Ying Tzang Tien, William R. Henderson
Publikováno v:
Journal of Biological Chemistry. 286:28049-28055
Group X (GX) phospholipase A(2), a member of a large group of secreted phospholipases A(2) (sPLA(2)s), has recently been demonstrated to play an important in vivo role in the release of arachidonic acid and subsequent formation of eicosanoids. In a T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a4b4c4148b3a0f980e9be2bf4b4fe
https://doi.org/10.1074/jbc.m111.235812
https://doi.org/10.1074/jbc.m111.235812
Publikováno v:
Free Radical Biology and Medicine. 50:1517-1525
In vitro and limited in vivo evidence suggests that reactive oxygen species derived from NADPH oxidases (NOX-ROS) play an important role in inflammatory responses by enhancing the activity of redox-sensitive cell signaling pathways and transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a5fe2e5997c150713160bc69884056
https://doi.org/10.1016/j.freeradbiomed.2011.02.027
https://doi.org/10.1016/j.freeradbiomed.2011.02.027
Autor:
Ying Tzang Tien, William R. Henderson, Emil Y. Chi, Zea Borok, Cu Nguyen, Michael Kahn, Beiyun Zhou, Xin Ye, Darryl A. Knight
Publikováno v:
Proceedings of the National Academy of Sciences. 107:14309-14314
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids have limited efficacy in this ultimately fatal disorder. An i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7186452e0c66b6e9a07ad20eb4dc22
https://doi.org/10.1073/pnas.1001520107
https://doi.org/10.1073/pnas.1001520107
Autor:
Ying Tzang Tien, Shi Han Chen, Xue Han Ning, Cheng Su Xu, Ming Ge, Michael A. Portman, Norman E. Buroker, Emil Y. Chi, Outi M. Hyyti
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H2119-H2128
Hypothermia preserves myocardial function, promotes signaling for cell survival, and inhibits apoptotic pathways during 45-min reperfusion. We tested the hypothesis that signaling at the transcriptional level is followed by corresponding proteomic re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d090b77e86ac5655b13d57944508f46
https://doi.org/10.1152/ajpheart.00123.2007
https://doi.org/10.1152/ajpheart.00123.2007
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 173:718-728
Airway inflammation in asthma is accompanied by structural changes, including goblet cell metaplasia, smooth muscle cell layer thickening, and subepithelial fibrosis. This allergen-induced airway remodeling can be replicated in a mouse asthma model.T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a4e072917fa31a8eeb4ba0ef66f816
https://doi.org/10.1164/rccm.200501-088oc
https://doi.org/10.1164/rccm.200501-088oc
Autor:
Emil Y. Chi, David B. Lewis, Richard K. Albert, Pia Eriksen, Falaah Jones, William R. Henderson, Wayne J. E. Lamm, Yu Zhang, Gertrude K S Chiang, Ying Tzang Tien, Mechthild Jonas
Publikováno v:
The Journal of Experimental Medicine
Inhalation of antigen in immunized mice induces an infiltration of eosinophils into the airways and increased bronchial hyperreactivity as are observed in human asthma. We employed a model of late-phase allergic pulmonary inflammation in mice to addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96912eacb8e4896ef7e227d3d8eb36e5
http://europepmc.org/articles/PMC2192843
http://europepmc.org/articles/PMC2192843
Autor:
Federico M. Farin, Theo K. Bammler, Ying Tzang Tien, Jun Xue, Clifford D. Wright, Richard P. Beyer, Xin Ye, William R. Henderson
Publikováno v:
D39. NOVEL THERAPEUTICS IN PULMONARY FIBROSIS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4a17b67399db8dbaa3845b65f0aabd2
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6043
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6043
Autor:
William R. Henderson, Jun Xue, Federico M. Farin, Richard P. Beyer, Ying Tzang Tien, Theo K. Bammler, Xin Ye
Publikováno v:
C21. NEW TARGETS FOR ASTHMA THERAPY.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a1ace0dbf619c5545852a8bec557793
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4066
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4066
Autor:
Gertrude K S Chiang, Emil Y. Chi, Xin Ye, Alan G. Singer, Alexander Y. Rudensky, Luca Castelli, Yuri P. Rubtsov, Michael H. Gelb, James G. Bollinger, William R. Henderson, Ying Tzang Tien, Timo J. Nevalainen
Publikováno v:
The Journal of Experimental Medicine
Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834bd8c73a18d7808859bf15bfdfe807
https://pubmed.ncbi.nlm.nih.gov/17403936
https://pubmed.ncbi.nlm.nih.gov/17403936