Zobrazeno 1 - 10 of 69 pro vyhledávání: '"Ying-Ta Wu"'
1
Akademický článek
Designing a bis-azide photoaffinity probe in labeling influenza nucleoprotein trimer to give an insight into the binding mode
Autor: Pin-Hsuan Chiu, Wei Huang, Hua-Ting Hsu, Wen-Feng Huang, Ying-Ta Wu, Ting-Jen Rachel Cheng, Jim-Min Fang
Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100091- (2022)
Targeting the highly conserved E330 … R416 salt bridge involved in nucleoprotein (NP) trimerization is considered a favorable approach to address the problem of drug resistance in influenza therapy. A photoaffinity probe (1) containing aryl and alk
Externí odkaz: https://doaj.org/article/299923ba6610420fad45f6db3d13136b
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2
Akademický článek
Cardio- and Neurotoxicity of Selected Anti-COVID-19 Drugs
Autor: Martin W. Nicholson, Ching-Ying Huang, Jyun-Yuan Wang, Chien-Yu Ting, Yu-Che Cheng, Darien Z. H. Chan, Yi-Chan Lee, Ching-Chuan Hsu, Yu-Hung Hsu, Cindy M. C. Chang, Marvin L. Hsieh, Yuan-Yuan Cheng, Yi-Ling Lin, Chien-Hsiun Chen, Ying-Ta Wu, Timothy A. Hacker, Joseph C. Wu, Timothy J. Kamp, Patrick C. H. Hsieh
Publikováno v: Pharmaceuticals, Vol 15, Iss 6, p 765 (2022)
Since December 2019, the novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected ~435 million people and caused ~6 million related deaths as of March 2022. To combat COVID-19, th
Externí odkaz: https://doaj.org/article/281becb748f34355a75c8da991a28a2e
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3
Akademický článek
In Vitro Evaluation of Novel Inhibitors against the NS2B-NS3 Protease of Dengue Fever Virus Type 4
Autor: Thi Thanh Hanh Nguyen, Sun Lee, Hsi-Kai Wang, Hsin-Yen Chen, Ying-Ta Wu, Simon C. Lin, Do-Won Kim, Doman Kim
Publikováno v: Molecules, Vol 18, Iss 12, Pp 15600-15612 (2013)
The discovery of potent therapeutic compounds against dengue virus is urgently needed. The NS2B-NS3 protease (NS2B-NS3pro) of dengue fever virus carries out all enzymatic activities needed for polyprotein processing and is considered to be amenable t
Externí odkaz: https://doaj.org/article/072b0e1870434811ab16698b37b0d3d7
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5
Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to developN-glycan modulators as anticancer agents
Autor: Wei-An Chen, Yu-Hsin Chen, Chiao-Yun Hsieh, Pi-Fang Hung, Chiao-Wen Chen, Chien-Hung Chen, Jung-Lee Lin, Ting-Jen R. Cheng, Tsui-Ling Hsu, Ying-Ta Wu, Chia-Ning Shen, Wei-Chieh Cheng
Publikováno v: Chemical Science. 13:6233-6243
An integrated strategy of Natural-Product-Inspired Combinatorial Chemistry (NPICC) and Computation-Guided Synthesis is used to develop an α-hGMII inhibitor with 106-fold selectivity over α-hLM, withinhibitory effect on hepatocellular carcinoma.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::013db59ee2a84083777e0e3baed8080c
https://doi.org/10.1039/d1sc05894k
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6
Abstract P3120: Cardio And Neurotoxicity Of Repurposed Anti-COVID-19 Drugs
Autor: Martin Nicholson, Ching-Ying Huang, Jyun-Yuan Wang, Ting Chien-Yu, Yu-Che Cheng, Darien Chan, Yi-Chan Lee, Ching-Chuan Hsu, Cindy M Chang, Marvin L. Hsieh, Yuan-Yuan Cheng, Yi-Ling Lin, Chien-Hsiun Chen, Ying-Ta Wu, Timothy A Hacker, Joseph C Wu, Timothy Kamp, Patrick C Hsieh
Publikováno v: Circulation Research. 131
In December 2019, the novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spread around the globe resulting in ~435 million confirmed cases and ~6 million related deaths as of March 2022,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2d8a25f0a27f0ab9160706a2f7c59b6
https://doi.org/10.1161/res.131.suppl_1.p3120
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9
Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation
Autor: Hao-Chun, Chuang, Ming-Fang, Liu, Hsin-Yi, Wu, Ying-Ta, Wu, Ting-Jen Rachel, Cheng, Jim-Min, Fang
Publikováno v: Bioorganic & Medicinal Chemistry. 67:116819
A series of salicylanilide compounds was previously identified as antibacterial agents that inhibit the peptidoglycan formation. To find the exact binding mode, we synthesized a benzophenone-containing salicylanilide compound (1) and used it as a pho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a416c65c8413675622d5c7046cf770
https://doi.org/10.1016/j.bmc.2022.116819
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10
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection
Autor: Ting-Jen R. Cheng, Jiun-Jie Shie, Jia Tsrong Jan, Ting Hung Chou, Wen-Bin Yang, Wei-Chieh Cheng, Chi-Huey Wong, Shang-Cheng Hung, Rong-Jie Chein, Hsiu Hua Ma, Cheng Wei Cheng, Pi-Hui Liang, Xiaorui Chen, Ying-Ta Wu, Che Ma, Yu Pu Juang, Shi Shan Mao
Publikováno v: Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118(5):e20211579118
Significance COVID-19 is a global pandemic currently lacking an effective cure. We used a cell-based infection assay to screen more than 3,000 agents used in humans and animals and identified 15 with antiinfective activity, ranging from 0.1 nM to 50
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006ff36b872509529e809eb42882f41c
https://doi.org/10.1073/pnas.2021579118
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